Navigation Links
HPV virus helps cervical and head and neck cancers resist treatment and grow and spread
Date:11/3/2008

rs to grow and spread more quickly could save lives, Rettig said.

"The virus appears to be regulating the expression of genes that control all of the characteristics of hypoxic tumors, those that promote survival, drug resistance and the spread of the cancers," Rettig said. "It's good for the tumor, bad for the patient."

In HPV-associated cancers, the HPV DNA is integrated into the cancer cell's genome, where it expresses a protein called E6. In the cancer cell's hypoxic environment, the protein targets a cell signaling pathway called NF-B, heightening its activation, Rettig said. This is the first time an association has been shown between the virus and hypoxia-induced activation of the cell signaling pathway.

The findings in the study happened by coincidence, Rettig said. He and his team were screening different cancer cell types for hypoxia-induced activation of the cell signaling pathway. When he looked at the results, Rettig noted that only the cancer cell types that were HPV-positive had heightened activation of the NF-B pathway. Cervical and head and neck cancers not caused by HPV did not have heightened activation of the pathway.

"The cells had to have the virus to have the activation," he said.

The next step for Rettig and his team is to confirm the findings in additional animal models to gain broader understanding of the potential correlation of hypoxia and activation of the cell signaling pathway in humans. He hopes to have a drug to test in human clinical studies in about five years.

HPV is the most common sexually transmitted disease in the world. About 20 million Americans currently are infected with HPV, according to the Centers for Disease Control, and another 6.2 million people become newly infected each year. At least 50 percent of sexually active men and women will acquire genital HPV infection at some point in their lives.

In addition to cervical and head and ne
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smaller mosquitoes are more likey to be infected with viruses causing human diseases
2. Special Mouth Rinse Spots, Tracks Human Papillomavirus Infection
3. HIV Test Kit Markets a New Development in the War Against the AIDS Virus, an Easy Home HIV Testing Device
4. How to select anti-hepatitis B virus agents for drug-resistance patients?
5. Pitt research indicates new virus is culprit, not bystander, in deadly skin cancer
6. The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
7. A potential approach to treatment of hepatitis B virus infection
8. Early treatment is key to combating hepatitis C virus
9. Researchers Find Genes That Influence West Nile Virus
10. HIV Drug Might Spur Resistant Strains of Virus
11. USPTO Issues Patent Embodying Methodologies for Abating a Broad Range of Allergens, Pathogens, Viruses, Bacteria, Odors and Volatile Organic Compounds.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Ethane Web Technologies, an ISO ... new service named ‘Java Development’. The service cost ... designed the service after doing a serious study ... service being provided by other web development companies. ... promise outstanding Java Development service. ...
(Date:7/31/2014)... for anyone, but for those with periodontal disease related to ... smiling. In a report appearing in the August 2014 issue ... one of the most important blood cells involved in the ... and bone loss in type 2 diabetes-associated periodontal disease. ... responses of B cells may treat or prevent this complication. ...
(Date:7/31/2014)... 2014 Healthpointe Medical Group, one ... maintaining the highest standards in health and safety ... is offering Occupational Medicine Services at ... patients. They also accept workers’ compensation cases and ... Medicine services include, but are not limited to, ...
(Date:7/31/2014)... 31, 2014 FORT LAUDERDALE, FLORIDA ... a leading US Joint Commission Accredited teleradiology and ... and technologically advanced consumer storage and sharing platform ... is providing valued members the use of its ... services already offered by SecondOpinions.com®. , Wide-spread ...
(Date:7/31/2014)... New York, NY (PRWEB) July 31, 2014 ... will host its first-ever event in New York on ... Eventi Hotel in Manhattan. , Featuring keynotes by ... Assemblyman Steve Katz (R-Yorktown), the event will include lunch ... Compassionate Care Act and the work NCIA is doing ...
Breaking Medicine News(10 mins):Health News:Ethane Web Technologies Announces Java Development Service at Pocket Friendly Cost 2Health News:Researchers uncover cause of gum disease related to type 2 diabetes 2Health News:Occupational Medicine Services Available at Healthpointe’s Perris Facility 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 3Health News:THURSDAY, AUG 7: First-Ever National Cannabis Industry Association Event in New York Will Feature Senator Savino, Assemblyman Katz, & Industry Leaders 2
... ... v 2.0 which is made up of three products: Semantics.Datacenter, Semantics.Server, and Semantics.Framework. ... industry standard benchmark tests (Berlin 100M 5/25/10). , ... Brattleboro, VT (PRWEB) June 17, 2010 -- ...
... ... Service; Simplicity, Security Benefits IP Telephony Implementation , ... Mississauga, Ontario (PRWEB) June 17, 2010 -- Phybridge ... compliant with key IP Telephony solutions from Avaya, a leading global provider of business ...
... ... a house boating trip at Sunset Marina and Resort. Beautiful Dale Hollow Lake offers ... of Tennessee. , ... Byrdstown, TN (PRWEB) June 17, 2010 -- Families are flocking to the hills of ...
... ... a weekly blog column about Internet Marketing. Paul Hannam will write about hot topics such ... practical strategies and case studies. , ... (PRWEB) June 17, 2010 -- San Diego-based Bright Green Leadership LLC, ...
... ... Website And Updated Web Hosting Plans That Provide The Resources And Services Needed To ... ... our customer in mind, Hosting Metro is proud to announce the launch of their ...
... ... Community Baby Shower for Philadelphia Mothers-to-be , ... Philadelphia, Pa. (Vocus) June 16, 2010 -- Keystone Mercy Health ... Family Services, Inc., a non-profit organization that provides health services to families, will host ...
Cached Medicine News:Health News:Intellidimension Releases New Version of Semantic Web Technologies 2Health News:Phybridge Network Solution Achieves Avaya “Compliant” Status 2Health News:Phybridge Network Solution Achieves Avaya “Compliant” Status 3Health News:Sunset Marina and Resort on Tennessee's Dale Hollow Lake Provides Affordable Houseboat Vacations for Price-Conscious Families 2Health News:Bright Green Leadership Partners with TriplePundit to Help Businesses Improve Their Green Marketing Online 2Health News:Hosting Metro Releases New Website and Upgraded Pricing Plans For All Web Hosting Packages 2Health News:Hosting Metro Releases New Website and Upgraded Pricing Plans For All Web Hosting Packages 3Health News:More Than 100 Philadelphia Expectant-Mothers and Their Families to Attend Keystone Mercy Health Plan's Community Baby Shower 2
(Date:7/31/2014)... July 31, 2014 Auxilium Pharmaceuticals, ... specialty biopharmaceutical company, today announced that the Company ... from its partner Asahi Kasei Pharma Corporation (Asahi ... successful submission of a regulatory application to the ... XIAFLEX ® (collagenase clostridium histolyticum) for the ...
(Date:7/30/2014)...  There is still time to share your ... Annual Institute for Supply Management ® – ... Management is open for submissions.  The annual competition ... of supply management by recognizing supply management organizations ... practices.  Entries are due August 22, 2014. ...
(Date:7/30/2014)... CryoLife, Inc. (NYSE: CRY), a leading medical ... vascular surgery, announced today that its Board of Directors ... quarter 2014 of $0.03 per share of common stock ... will be paid on September 19, 2014 to all ... The ex-dividend date for the quarterly dividend is September ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 2Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 3Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 4Auxilium Pharmaceuticals, Inc. Announces XIAFLEX Milestone: Partner Asahi Kasei Pharma Corporation Completes Regulatory Submission For Dupuytren's Contracture In Japan 5Institute for Supply Management, Michigan State University to recognize companies with excellent supply management practices 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 2CryoLife Announces Quarterly Cash Dividend for the Third Quarter 2014 3
... II data show RAD001 significantly increased efficacy of, letrozole tablets in women with newly diagnosed hormone-positive ... cancer, ... ... breast cancer by ...
... Presented at ASCO Annual Meeting -, ... 1 /PRNewswire-FirstCall/,-- Poniard Pharmaceuticals, Inc. (Nasdaq: ... today announced safety and efficacy results,from a ... picoplatin and,liposomal doxorubicin in patients with advanced ...
Cached Medicine Technology:Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 2Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 3Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 4Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 5Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 6Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 7Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 8Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments 9Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer 2Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer 3Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer 4Poniard Announces Positive Efficacy and Safety Data From Phase 1 Trial of Picoplatin in Multiple Tumor Types Including Ovarian Cancer 5
... ventricular drainage set (EVD set) ... for external ventricular drainage. It ... with a ventricular catheter or ... probe from the Aesculap Spiegelberg ...
... The Trippi-Wells and Universal tongs were ... are needed than can be safely provided ... ring. Titanium construction. Kit complete with four ... or four pin application. Skull pins at ...
... neuro and skull base surgery. Complete ... surgery, pediatric neurosurgery, bony defects of ... base regions, neuro trauma. Dedicated neuro/skull ... in one compact kit. MRI and ...
Hand Drill, with two-position Handle, with Jacob three-jaw chuck, wrench-locked for changing twist drills up to 6 mm...
Medicine Products: