Navigation Links
HPV virus helps cervical and head and neck cancers resist treatment and grow and spread
Date:11/3/2008

rs to grow and spread more quickly could save lives, Rettig said.

"The virus appears to be regulating the expression of genes that control all of the characteristics of hypoxic tumors, those that promote survival, drug resistance and the spread of the cancers," Rettig said. "It's good for the tumor, bad for the patient."

In HPV-associated cancers, the HPV DNA is integrated into the cancer cell's genome, where it expresses a protein called E6. In the cancer cell's hypoxic environment, the protein targets a cell signaling pathway called NF-B, heightening its activation, Rettig said. This is the first time an association has been shown between the virus and hypoxia-induced activation of the cell signaling pathway.

The findings in the study happened by coincidence, Rettig said. He and his team were screening different cancer cell types for hypoxia-induced activation of the cell signaling pathway. When he looked at the results, Rettig noted that only the cancer cell types that were HPV-positive had heightened activation of the NF-B pathway. Cervical and head and neck cancers not caused by HPV did not have heightened activation of the pathway.

"The cells had to have the virus to have the activation," he said.

The next step for Rettig and his team is to confirm the findings in additional animal models to gain broader understanding of the potential correlation of hypoxia and activation of the cell signaling pathway in humans. He hopes to have a drug to test in human clinical studies in about five years.

HPV is the most common sexually transmitted disease in the world. About 20 million Americans currently are infected with HPV, according to the Centers for Disease Control, and another 6.2 million people become newly infected each year. At least 50 percent of sexually active men and women will acquire genital HPV infection at some point in their lives.

In addition to cervical and head and ne
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smaller mosquitoes are more likey to be infected with viruses causing human diseases
2. Special Mouth Rinse Spots, Tracks Human Papillomavirus Infection
3. HIV Test Kit Markets a New Development in the War Against the AIDS Virus, an Easy Home HIV Testing Device
4. How to select anti-hepatitis B virus agents for drug-resistance patients?
5. Pitt research indicates new virus is culprit, not bystander, in deadly skin cancer
6. The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
7. A potential approach to treatment of hepatitis B virus infection
8. Early treatment is key to combating hepatitis C virus
9. Researchers Find Genes That Influence West Nile Virus
10. HIV Drug Might Spur Resistant Strains of Virus
11. USPTO Issues Patent Embodying Methodologies for Abating a Broad Range of Allergens, Pathogens, Viruses, Bacteria, Odors and Volatile Organic Compounds.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Photodynamic therapy (PDT, which uses topical agents and light ... (AKs, a common skin lesion caused by sun damage) ... liquid nitrogen to freeze lesions). , Author: ... Davis Medical Center, in Sacramento, and colleagues. , ... skin typically found on individuals with fair complexions who ...
(Date:8/27/2014)... play a key role in inflaming blood vessels and ... study at UCLA demonstrates that they may also contribute ... the small blood vessels in the lungs. , Using ... mimicking part of the main protein in high-density lipoprotein ... production of oxidized lipids in pulmonary hypertension. They also ...
(Date:8/27/2014)... August 27, 2014 The federal judge ... ) has extended the deadline for plaintiffs to enroll ... 2014 Order issued by U.S. District Judge David Katz ... enroll in the DePuy ASR Settlement Program must do ... Inc. ASR Hip Implant Products Liability Litigation – MDL ...
(Date:8/27/2014)... August 27, 2014 Ticket Down is a ... at Sun Life Stadium in Miami. The Brazilian national ... on September 5 at Sun Life Stadium in Miami Gardens, ... a rematch of the World Cup earlier this year when ... to injury. The Brazilian Soccer Federation announced earlier this week ...
(Date:8/27/2014)... 27, 2014 Connor Sports has ... World Cup in Spain at the Barcelona, Bilbao, Gran ... FIBA Equipment & Venue Centre Partner since 1994 and Official ... six courts will bear the Connor Sports logo and tagline ... globe on the ESPN broadcasts of the FIBA World Cup. ...
Breaking Medicine News(10 mins):Health News:Photodynamic therapy vs. cryotherapy for actinic keratoses 2Health News:Protein in 'good cholesterol' may be a key to treating pulmonary hypertension 2Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 2Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 3Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 3Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 2Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 3
... potent antioxidant , FRIDAY, Nov. 13 (HealthDay News) -- ... yellow curry ingredient curcumin, which is being tested in ... and Alzheimer,s disease. , Curcumin, the active ingredient in ... juices in the gastrointestinal tract quickly destroy curcumin, which ...
... one than age, study finds , FRIDAY, Nov. 13 (HealthDay News) ... than in 50-year-old women, according to a study that found that ... The analysis of data from the Million Women Study of 1.3 ... women aged 50 to 54, the risk of hip fracture of ...
... 13 A surprisingly easy and low-cost system of ... with Crohn,s disease and ulcerative colitis, a study released ... an online information network, allowing caregivers to systematically collect ... and their effectiveness. Creation and use of this ...
... Inc. (Nasdaq: BMRN ) announced today that Genzyme ... detected foreign particles in some products filled at the ... not exposed to foreign particles during product administration, Genzyme ... treating patients with enzyme replacement products that it markets, ...
... Nov. 13 Americans may realize that they have a ... underestimate the cost of care, believe government programs cover more ... deal with their own potential care. A national survey of ... of LTC Awareness Month (November) and John Hancock,s "Know Your ...
... for hepatitis and more , FRIDAY, Nov. 13 (HealthDay ... an extensive database about proteins produced by genes in ... the foundation for new treatments for liver disease. , ... kind for any organ, the researchers examined 10 liver-tissue ...
Cached Medicine News:Health News:'Global Bulletin Board' Shows Promise in Child Health 2Health News:'Global Bulletin Board' Shows Promise in Child Health 3Health News:'Global Bulletin Board' Shows Promise in Child Health 4Health News:Particles Detected in Vials from Genzyme's Plant Not Expected to Impact Aldurazyme or Naglazyme 2Health News:Particles Detected in Vials from Genzyme's Plant Not Expected to Impact Aldurazyme or Naglazyme 3Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 2Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 3Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 4Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 5Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 6
(Date:8/27/2014)... BOSTON , Aug. 27, 2014  Columbia Laboratories, ... Company"), a provider of pharmaceutical development, clinical trial manufacturing, ... industry, today announced that it will participate at the ... Investment Conference, to be held in New ... conference at 11:15am on September 9, 2014 at the ...
(Date:8/27/2014)... and NINGBO, China , ... the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced ... development of generic pharmaceuticals, primarily targeting the ... the agreement, Amerigen and Menovo will jointly develop products ... States . Menovo will be responsible for manufacturing ...
(Date:8/27/2014)... 2014 /CNW/ - Covalon Technologies Ltd. (the "Company" or "Covalon") ... financial results for its third quarter of fiscal 2014: ... , Revenue of $1,291,378, a 13% decrease over the ... for the quarter of $240,156 compared to net income of ... For the nine months ended June 30, 2014: ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Covalon Announces Third Quarter Results 2Covalon Announces Third Quarter Results 3
... Designs ROM post-operative knee braces are designed ... rehabilitation. , ,Adjustable and versatile, ROM ... for health care professionals. The braces are ... feature quick dial combination hinges that allow ...
... Neuroprene™ soft supports are a convenient, ... proprioceptive taping for common orthopedic conditions/instabilities. ... provide specific compression and lateral to ... (proprioceptors) in the skin and soft ...
... The Deluxe Heavy Duty Drop Lock Post Operative ... pin hinge with a spring loaded drop lock ... arms and contoured plates prevent the brace from ... a tibial offset for anatomical alignment that controls ...
... might just be the world's most versatile ... support, post-op/rehab support, or both, Flex is ... Accutrac™ ROM hinges control flexion and extension ... durability while being heat-moldable to accommodate changes ...
Medicine Products: