Navigation Links
HPV virus helps cervical and head and neck cancers resist treatment and grow and spread
Date:11/3/2008

The human papillomavirus (HPV) allows infected cervical and head and neck cancer cells to maintain internal molecular conditions that make the cancers resistant to therapy and more likely to grow and spread, resulting in a poor prognosis for patients, researchers with UCLA's Jonsson Cancer Center found.

Virtually all human cancers experience a state called intratumoral hypoxia, or a low amount of oxygen within the tumor. In the UCLA study, researchers showed that the HPV-positive cancers adapted to and took advantage of the hypoxic environment by expressing a protein that activates a cell signaling pathway that helps the cancers survive, grow and spread.

The study is published in the Nov. 4, 2008 issue of the journal Cancer Cell.

The research, done on cells in culture and in animal models, may lead to the development of new therapies that target the cell signaling pathway, thereby interrupting ability of the cancer cells to thrive, said Dr. Matthew Rettig, senior author of the study and a researcher at UCLA's Jonsson Comprehensive Cancer Center.

"There is potential for therapeutic intervention based on this finding," said Rettig, an associate professor of urology and medicine.

The finding is crucial because 90 to 98 percent of cervical cancers are caused by HPV. Cervical cancer is the second most common cancer in women worldwide, with more than 500,000 cases diagnosed annually. In all, 200,000 women die from cervical cancer every year. In oral cavity and pharynx cancers, the HPV virus is linked to about 20 to 40 percent of cases, caused by sexual behavior. About 400,000 cases of head and neck cancer are diagnosed worldwide each year, and more than half of those patients die of the disease.

In those cases where the cancer is HPV-positive, which number in the hundreds of thousands, the virus will make the disease more aggressive and deadly. Finding a way to stop the virus from prompting the cance
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Smaller mosquitoes are more likey to be infected with viruses causing human diseases
2. Special Mouth Rinse Spots, Tracks Human Papillomavirus Infection
3. HIV Test Kit Markets a New Development in the War Against the AIDS Virus, an Easy Home HIV Testing Device
4. How to select anti-hepatitis B virus agents for drug-resistance patients?
5. Pitt research indicates new virus is culprit, not bystander, in deadly skin cancer
6. The prevalence of hepatitis B virus infection in inflammatory bowel disease patients
7. A potential approach to treatment of hepatitis B virus infection
8. Early treatment is key to combating hepatitis C virus
9. Researchers Find Genes That Influence West Nile Virus
10. HIV Drug Might Spur Resistant Strains of Virus
11. USPTO Issues Patent Embodying Methodologies for Abating a Broad Range of Allergens, Pathogens, Viruses, Bacteria, Odors and Volatile Organic Compounds.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... A disorder of the nerves, Diabetic neuropathy ... to neuropathy expert doctor Helen C Lin, on Medscape ... disorder affects almost 50% of all Diabetic patients, making ... high blood sugar levels in the body are the ... usually tend to have abnormally high blood sugar levels. ...
(Date:5/25/2013)... News) -- Animals make great companions for senior citizens, but ... car are far more likely to crash than those who ... new study included 2,000 licensed drivers aged 70 and older. ... often they drove with their pet in the car. ... risk was twice as high as among those who never ...
(Date:5/25/2013)... 2013 Studies from Johns Hopkins University ... excessive weight and their inability to get adequate sleep. ... weight can naturally relieve many symptoms. , Johns ... sleep quality was significantly associated with overall weight loss, ... dated November 6th, 2012, researchers monitored 77 participants ...
(Date:5/25/2013)... New York, NY (PRWEB) May 25, 2013 ... reported that many people do not wish to discuss or ... responsibility in life. FuneralFinancials.com released a Must-Do ... , 1. Funeral Financials recommends, “Creating a personal fact ... be used to organize financial information and personal data. ...
(Date:5/25/2013)... May 25, 2013 By working diligently ... declared the integration of the 2012 Lamborghini Aventador into ... the latest entrant in the list of vehicles lined ... vehicle is all set to thrill automobile lovers in ... power and spectacular looks, the 2012 Lamborghini Aventador comes ...
Breaking Medicine News(10 mins):Health News:Diabetic Neuropathy treatment hits new grounds- Neuracel launches the complete natural treatment 2Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep 2Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2Health News:Rim Fitments Provider SizeItUp Launches The Database Integration For The 2012 Lamborghini Aventador 2
... shafts offer up personal history, researchers say , , ... drink stays in your hair, and it may reveal ... By analyzing the makeup of water molecules from human ... determine the regions where people recently lived. While the ...
... OMCL ), a leading provider of system solutions ... Directors has approved the,repurchase of an aggregate of up ... 12 months. The Company,s Board of Directors decided to ... Company,s financial position and,investment alternatives. The Company expects the ...
... who have tested positive for the human immunodeficiency virus (HIV) ... future, recent research suggests. , A womans age at the ... this decision. Women in an Ohio State University study who ... 30 were almost four times more likely to say they ...
... new blockages within 3 years, study finds , , ... a blood clot in their legs (deep vein thrombosis) ... of developing another blood clot within three years, a ... embolism are known collectively as venous thromboembolism. , Researchers ...
... Planning Inc., form "MaxLife-CGP",Partners LLC., a California based operation. "MaxLife-CGP" ... dollars in face value, of which the Joint ... ... Feb. 25 /PRNewswire-FirstCall/ - MaxLife Fund Corp.,(OTC:MXFD). MaxLife Fund Corp. ...
... For years, getting a lot of,calcium has been portrayed ... to,prevent osteoporosis and related bone fractures. Small study results,supported ... data from,large, prospective studies that followed people for many ... issue of the Harvard,Health Letter., The ambiguity led ...
Cached Medicine News:Health News:Hair Tells Tale of Where You've Been 2Health News:Hair Tells Tale of Where You've Been 3Health News:Omnicell Announces Common Stock Repurchase Program; Reaffirms Earnings Forecast 2Health News:Omnicell Announces Common Stock Repurchase Program; Reaffirms Earnings Forecast 3Health News:About one-quarter of women with HIV want to become pregnant 2Health News:About one-quarter of women with HIV want to become pregnant 3Health News:About one-quarter of women with HIV want to become pregnant 4Health News:Blood Clots in Legs, Lungs Predispose Patients to Repeat Episodes 2Health News:MaxLife Fund Corp. and Capital Growth Planning Inc., sign a joint venture agreement 2Health News:MaxLife Fund Corp. and Capital Growth Planning Inc., sign a joint venture agreement 3Health News:High Calcium Intake May Not Help Prevent Fractures, Reports The Harvard Health Letter 2
(Date:5/23/2013)... DIEGO y PARÍS, 24 de mayo ... VOLC ), un destacado desarrollador y fabricante de ... mejorar la diagnosis y tratamiento de la enfermedad ... preliminares del ensayo ADVISE ( Ad enosine ... E valuation) II durante la sesión de ...
(Date:5/23/2013)... THOUSAND OAKS, Calif. , May 23, 2013 ... Deutsche Bank 38 th Annual  Healthcare Conference on Thursday, ... Boston , beginning at 9:20 a.m. Eastern Daylight ... Investor Relations at Amgen, will present at the conference. Live ... Calendar on Amgen,s website, www.amgen.com , under Investors. A ...
(Date:5/23/2013)... RIVER EDGE, N.J. , May 23, 2013 /PRNewswire/ ... ), a commercial stage medical device company that develops ... the successful completion of its rights offering.  In addition, ... company,s March 2011 warrants expired on May 17, 2013. ... proceeds of $3.0 million from the rights offering.   A ...
Breaking Medicine Technology:Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6Nephros Announces Completion of Rights Offering 2Nephros Announces Completion of Rights Offering 3Nephros Announces Completion of Rights Offering 4
... More,Efficiently than Male Cells, PITTSBURGH, April 09, 2007 /PRNewswire/ ... ability to regenerate skeletal,muscle tissue than male cells, according ... , The study, which is being published in the ... the first ever to report a difference,in regenerative capabilities ...
... BEVERLY, Mass.--(BUSINESS WIRE)--Apr 10, 2007 - Inotek,Pharmaceuticals Corporation ... preclinical animal data showing that the,administration of a ... on the survival of certain brain,cells following a ... the,repair of damaged DNA via the activation and ...
Cached Medicine Technology:The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 2The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 3Inotek Pharmaceuticals Announces Publication of Animal Data from,Study of PARP Inhibition as Potential Preventative of Brain Injury,Following Stroke 2Inotek Pharmaceuticals Announces Publication of Animal Data from,Study of PARP Inhibition as Potential Preventative of Brain Injury,Following Stroke 3
The first book to translate key medical data into clear guidelines capturing the highest treatment standards for heart disease....
... Notes is a quick-lookup reference for ... pocket guide presents the basics (anatomy ... electrical conduction system of the heart, ... and CPR algorithms, emergency medications, and ...
... Cochrane Reviews enable all those involved ... date with the very latest evidence in ... which becomes harder each year as the ... this problem by delivering the best single ...
... CVMstat® provides leading ... of topics involving all ... including sections on diagnosis ... arterial and venous disease. ...
Medicine Products: