Navigation Links
HPV vaccine reduces infection, even in unvaccinated
Date:7/8/2012

The HPV vaccine not only has resulted in a decrease in human papillomavirus infection in immunized teens but also in teens who were not immunized.

The study is believed to be the first to show a substantial decrease in HPV infection in a community setting as well as herd protection a decrease in infection rates among unimmunized individuals that occurs when a critical mass of people in a community is immunized against a contagious disease.

The Cincinnati Children's Hospital Medical Center study will be published online July 9 in the eFirst pages of Pediatrics.

"Infection with the types of HPV targeted by the vaccine decreased in vaccinated young women by 69 percent," says Jessica Kahn, MD, MPH, a physician in the division of Adolescent Medicine at Cincinnati Children's and lead author of the study. "Two of these HPV types, HPV-16 and HPV-18, cause about 70 percent of cervical cancer. Thus, the results are promising in that they suggest that vaccine introduction could substantially reduce rates of cervical cancer in this community in the future."

The first HPV vaccine was licensed for use in the United States in June 2006. The U.S. Advisory Committee on Immunization Practices has recommended vaccination of girls and women between the ages of 11 and 26 to reduce rates of HPV infection, which ultimately can lead to cervical cancer.

In 2006 and 2007, Dr. Kahn and colleagues at Cincinnati Children's recruited 368 young women between the ages of 13 and 16 from two primary care clinics in the city of Cincinnati. The young women had sexual contact but none were vaccinated. In 2009 and 2010, they recruited a different group of 409 young women in the same age range, more than half of whom had received at least one dose of the vaccine. The researchers compared pre- and post-vaccination HPV prevalence rates.

The prevalence of vaccine-type HPV decreased 58 percent overall, from 31.7 percent to 13.4 percent. The decrease was high among vaccinated participants (69 percent), but also was substantial for those who were unvaccinated (49 percent).

Dr. Kahn says the decrease in vaccine-type HPV among vaccinated participants was "especially remarkable," given that participants were sexually experienced, many were exposed to vaccination-type HPV before vaccination, and only one dose of the vaccine was required to be considered vaccinated.

Dr. Kahn emphasizes that despite the evidence of herd immunity demonstrated in her study, vaccination of all young women between the ages of 11 and 26 is important to maximize the health benefits of vaccination.

Although vaccine-type HPV decreased, the overall prevalence of HPV (including types not targeted by the vaccine) in the study was "extremely high," says Dr. Kahn. "Nearly one in four unvaccinated study participants was already positive for at least one high-risk HPV type."

Most participants in the study were young, black women, many with Medicaid insurance. Given this, and the fact that the study was a relatively small one conducted in a single city, larger studies with more representative samples are needed to definitively determine the public health impact of the HPV vaccine, says Dr. Kahn.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Young girls more likely to report side effects after HPV vaccine
3. Preteens More Likely to Report HPV Vaccine Side Effects
4. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
5. Early Study Finds Some Promise for Lung Cancer Vaccine
6. From a Failed Vaccine, New Insights Into Fighting HIV
7. From herd immunity and complacency to group panic: How vaccine scares unfold
8. Brain Tumor Vaccine Shows Promise in Early Trial
9. Army researcher develops potential vaccine carrier
10. A physicians guide for anti-vaccine parents
11. Shingles Vaccine Safe, Underutilized, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... The Portee Insurance Agency, a ... business owners in central Maryland and the DC region, is inaugurating a charity event ... people nationally every year, making it the #1 killer in America. However, heart disease ...
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their commitment ... they have achieved certification to ISO 13485. This certification is another way they are ... date products and services that they need. , The ISO 13485 Certification is a ...
(Date:1/18/2017)... ... January 18, 2017 , ... Catalent Pharma Solutions, the leading ... consumer health products, today announced that Mr. Michael Merges, Director of Strategic Growth, ... be held at the Mayflower Hotel, Washington DC, on Jan. 24 – 26, ...
(Date:1/18/2017)... ... 2017 , ... The Hear the World Foundation, a Sonova ... of cochlear implants. In February 2017, the first three children with profound hearing ... leading an independent life. This engagement builds on the support the Hear the ...
(Date:1/18/2017)... CA (PRWEB) , ... January 18, 2017 , ... ... dental problems ranging from gum disease to enamel erosion, and those dental problems ... Massachusetts Department of Public Health, many pregnant women are failing to get the ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... DUBLIN , Jan 18, 2017 Research ... Nausea and Vomiting Drugs Market 2017-2021" report to their offering. ... The global ... the period 2017-2021. Global Thoracic Surgery Market 2017-2021, ... from industry experts. The report covers the market landscape and its ...
(Date:1/18/2017)... Jan. 18, 2017 In China ... is where the Upgrade of China,s ... 13th Five-Year Plan for Economic and Social Development of ... Five-Year Plan), and the state council of the ... national strategic emerging industry development plan, identifying medical devices as ...
(Date:1/18/2017)... , January 18, 2017 Ximbio, a ... share research resources, has opened its first North American headquarters ... ... an expansion for Ximbio following its launch in October 2014 ... Technology (CRT), the commercialization arm of the foundation Cancer Research ...
Breaking Medicine Technology: