Navigation Links
HPV testing in HIV-positive women may help reduce frequent cervical cancer screening
Date:7/22/2012

July 22, 2012 (BRONX, NY) Compared to the general population, HIV-positive women have a high risk of cervical cancer and thus are advised to undergo more frequent screening tests. This creates a burden for HIV-positive patients and the health care system, leading to frequent biopsies, which often do not reveal clinically relevant disease.

A new study by researchers at Albert Einstein College of Medicine of Yeshiva University suggests that HIV-positive women may be able to use new methods that can help to safely reduce the frequency of screening in some women, similar to practices accepted in the general population. The findings will be published in the July 25 issue of the Journal of the American Medical Association (JAMA), a theme issue on HIV/AIDS.

Howard Strickler, M.D., M.P.H. professor of epidemiology and population health at Einstein and senior author of the study, presented the findings today at a JAMA media briefing at the International AIDS Conference.

As of 2009, 1.2 million people age 13 and older were living with HIV in the United States, according to the Centers for Disease Control and PreventionWomen accounted for about one-quarter of those infected.

In March 2012, the United States Preventive Services Task Force revised its cervical cancer screening guidelines for HIV-negative women aged 30 or older to once every five years from once every three years provided they have a normal Pap smear test and a negative test for human papillomavirus (HPV), the virus mainly responsible for cervical cancer. The Pap test detects precancerous or cancerous changes in the cervical lining and the HPV test detects cancer-associated types of the virus.

But those guidelines did not update screening recommendations for HIV-positive women. Current recommendations for HIV-positive women are to have two Pap tests, at six-month intervals, in the first year following diagnosis of HIV and, if normal, on an annual basis from then on. HPV testing is not currently recommended for HIV-positive women.

The current study looked at whether cervical cancer screening could be reduced in HIV-positive women who have a normal Pap test and a negative test for HPV. The Einstein researchers reasoned that for women with a normal Pap test and no evidence of cervical HPV infection, the risk of cervical precancer or cancer is likely to be very low for several years regardless of HIV status.

It is widely thought that before cervical precancer or cervical cancer can develop, there must be persistent infection by a cancer-associated HPV, as well as the accumulation of additional genetic changes over time, said Dr. Strickler.

The study analyzed data on 420 HIV-positive and 279 HIV-negative women who were enrolled in the Womens Interagency HIV Study (WIHS), the largest prospective study of HIV-positive women in the US. (Montefiore Medical Center, the University Hospital for Einstein, is one of the six clinical sites for WIHS.) At enrollment, each woman had a normal Pap test and tested negative for the cancer-related HPV types. The womens rates of cervical precancer and cancer were measured after three- and five-years of follow-up.

At both the three- and five-year screening intervals, the incidence of cervical precancer was found to be similar in both HIV-positive and HIV-negative women. No cases of cervical cancer were detected in either group.

Overall, few cases of cervical precancer would have gone undiagnosed if the HIV-positive women did not have any additional Pap tests during the five years following enrollment no more than in the HIV-negative group, said lead author Marla Keller, M.D., associate professor of medicine and of obstetrics & gynecology and womens health at Einstein and attending physician, medicine at Montefiore. Thus, these data raise the possibility that HPV and Pap co-testing could be used to reduce the burden of frequent Pap tests and, by extension, unnecessary biopsies in HIV-positive women who are in long-term clinical follow-up.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Psychological testing may predict success in soccer
2. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
3. Proposed testosterone testing of some female olympians challenged by Stanford scientists
4. Guidelines Issued for When Docs Should Order Vascular Testing
5. Experts recommend men at risk for osteoporosis undergo bone density testing
6. Wednesday Is National HIV Testing Day
7. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
8. NIH study finds HIV-positive young men at risk of low bone mass
9. Surgeons Seek Repeal of Transplant Ban Between HIV-Positive People
10. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
11. 62 percent of men and 37 percent of women over the age of 65 are sexually active
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... Texas (PRWEB) , ... August 16, 2017 , ... Ten ... Credit Union's Stars in the Classroom and will win a visit by a Houston ... grades K-12 who are at least five years old can visit texanschecking.com/stars to nominate ...
(Date:8/16/2017)... ATLANTA, Georgia (PRWEB) , ... August 16, 2017 ... ... practice in Atlanta, opened their doors. They celebrate 30 years in business this ... to create an up-to-date, inviting, tranquil space to serve their patients. , ...
(Date:8/16/2017)... ... August 16, 2017 , ... Maury Regional Health has announced a ... By broadly deploying AccuVein devices, Maury Regional Medical Center is making vein visualization part ... of a needle stick and more importantly, helps our staff members locate a vein ...
(Date:8/16/2017)... New Cumberland, PA (PRWEB) , ... August 16, 2017 , ... ... announced today it has successfully opened clubfoot clinics in all 29 Indian states—bringing the ... its newest clinic in Kangra, Himachal Pradesh, the nonprofit organization is on track to ...
(Date:8/16/2017)... ... August 16, 2017 , ... Fusion Flix Inc., a Telly ... over four countries and millions of viewers in a partnership with the Amazon Video ... On-Demand and fully available on Blu Ray disc in 2018. Proceeds will be going ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... -- Three Tru-D SmartUVC robots have arrived at Brian Allgood ... Tru-D, short for "Total Room Ultraviolet Disinfection," is a 5-foot-5 germ-killing robot ... (ES) professional cleans the area with traditional cleaning protocols. ... Tru-D fights germs at Army hospitals ... "Although the BAACH has a very low infection rate, ...
(Date:7/27/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today reported ... The Company reported second quarter net sales of $1.954 ... period, and an increase of 2.1% on a constant ... from the LDR Holding Corporation acquisition, second quarter 2017 ... or 0.3% on a constant currency basis. ...
(Date:7/26/2017)... BEACH, Fla. , July 26, 2017 ... of enrollment of our clinical trial evaluating Altemia TM ... Cell Anemia (SCA) and Sickle Cell Disease (SCD). The ... to evaluate the efficacy and safety of Altemia TM ... trial is conducted under US IND 125274. ...
Breaking Medicine Technology: