Navigation Links
HPV strains affecting African-American women differ from vaccines
Date:10/28/2013

NATIONAL HARBOR, M.D. Two subtypes of human papillomavirus (HPV) prevented by vaccines are half as likely to be found in African-American women as in white women with precancerous cervical lesions, according to researchers at Duke Medicine.

The findings, presented on Oct. 28, 2013, at the 12th annual International Conference on Frontiers in Cancer Prevention Research hosted by the American Association for Cancer Research, suggest that African-American women may be less likely to benefit from available HPV vaccines to prevent cervical cancer.

HPV is a common sexually transmitted infection with more than 40 subtypes. The virus causes nearly all cases of cervical cancer, which begin as precancerous cervical abnormalities. Two vaccines currently available to young women prevent infection by HPV 16 and HPV 18, the HPV strains responsible for about 70 percent cervical cancers.

"Screening programs for cervical cancer are known to work well, with around 90 percent of sexually active women getting screened through Pap tests," said senior author Cathrine Hoyo, Ph.D., M.P.H., associate professor of obstetrics and gynecology at Duke University School of Medicine.

"The question is, if screening rates are comparable in African-American and white women, why are the rates of cervical cancer and mortality higher among African-American women when we have a program that works so well?"

Hoyo and her colleagues sought to better understand these disparities by determining if African-American and white women in the U.S. are infected with the same subtypes of HPV. The researchers enrolled 572 participants -- 280 African-American women and 292 non-Hispanic white women -- who came for additional testing after receiving abnormal Pap test results.

Of the 572 participants, 245 (43 percent) had no precancerous cervical abnormalities, 239 (42 percent) had early precancerous cervical abnormalities, and 88 (15 percent) had advanced precancerous cervical abnormalities. Seventy-three percent of the women infected with HPV were infected with multiple HPV subtypes.

When the researchers looked at the specific strains of HPV, they found that white women and African-American women were often infected with different subtypes. The most frequent HPV subtypes detected among white women with early precancerous cervical abnormalities were 16, 18, 56, 39 and 66, while HPV subtypes 33, 35, 58 and 68 were the most common ones detected in African-Americans.

In those with advanced precancerous cervical abnormalities, HPV 16, 18, 33, 39 and 59 were the most common genotypes detected in white women, whereas HPV 31, 35, 45, 56, 58, 66 and 68 were the most prevalent in African-American women.

"Compared with white women, we saw that African-American women had about half as many infections with HPV 16 and 18, the subtypes that are covered by HPV vaccines," said Adriana Vidal, Ph.D., assistant professor of obstetrics and gynecology at Duke University School of Medicine and the study's first author. "Since African-American women don't seem to be getting the same subtypes of HPV with the same frequency, the vaccines aren't helping all women equally."

A new HPV vaccine targeting nine HPV subtypes (6, 11, 16, 18, 31, 33, 45, 52 and 58) is currently being tested in phase III trials. While the new vaccine may help prevent additional HPV infections by covering new subtypes, it may not address the disparities found in this study.

"The most disconcerting part of this new vaccine is it doesn't include HPV 35, 66 and 68, three of the strains of HPV of which African-American women are getting the most," Hoyo said. "We may want to rethink how we develop these vaccines, given that African-Americans tend to be underrepresented in clinical trials."

The researchers noted that while these findings are compelling, the results are preliminary and the studies should be replicated in larger populations. Hoyo, Vidal and their colleagues are also continuing the research to define epigenetic marks that can be used to predict which precancerous cervical abnormalities will advance.


'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Beautiful New Strains of Nevil’s Medical Marijuana Seeds and Reeferman Medical Marijuana Seeds Now Available Online from R.M.S.S.
2. MedMar Healing Center, Taking Clone Pre-Orders for High-Quality Medical Marijuana Strains
3. Prediction of seasonal flu strains improves chances of universal vaccine
4. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
5. Some Whooping Cough Strains Now Outsmarting Vaccine
6. Infection With 2 HIV Strains Slows Disease Progression
7. Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains
8. Test links strains of common parasite to severe illness in US newborns
9. According to the United Health Foundation, The Burden of Diabetes in Missouri is on the Rise, Affecting Over Ten Percent of Residents
10. Southwestern Ear, Nose & Throat Associates Offers Guidelines On Hearing Loss, Lack of Sleep Affecting Back-to-School Health
11. American Medical Association Defines Obesity as a Disease Affecting 90 Million Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... DMG Productions, producers of the ... in an upcoming episode, slated to air fourth quarter 2017. Check your local ... Group; a company committed to supporting dentistry using the most technologically advanced restorative ...
(Date:8/19/2017)... ... August 18, 2017 , ... President ... of 2017, legislation that provides for greater public access to over-the-counter (OTC) hearing ... to access OTC hearing aids without being seen by a certified and licensed ...
(Date:8/19/2017)... ... 2017 , ... Praeclarus Press has launched a new ... the diversity of the breastfeeding mothers, using bright colors and contemporary themes. These ... are also available on tote bags, notepads, smartphone cases, clocks, and travel mugs. ...
(Date:8/19/2017)... Fla. (PRWEB) , ... August 19, 2017 , ... ... Taufiq Ahmed, M.D., has joined its Orlando location as an interventional pain management ... anesthesiology, a focus on the treatment of migraine headaches, and significant experience in ...
(Date:8/18/2017)... , ... August 18, 2017 , ... More than 20,000 ... Republic of Congo (DRC) thanks to an ambitious venture that conjoined the passions of ... the generous support of the Liberty community. These shoes will save lives from the ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... ROCKVILLE, Md. , Aug. 4, 2017 ... during or shortly after a physician/patient consult has long ... industry, and was a notable focus of the largest ...  This is according to healthcare market research firm Kalorama ... of care testing (POCT) offerings or related supplies and ...
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation ... Surgical System to support its strategic sales plan in ... and Virginia.  7D Surgical has entered into an exclusive sales ... medical facilities within those markets. ... Spartan Medical Purchases ...
Breaking Medicine Technology: