Navigation Links
HPV strains affecting African-American women differ from vaccines

NATIONAL HARBOR, M.D. Two subtypes of human papillomavirus (HPV) prevented by vaccines are half as likely to be found in African-American women as in white women with precancerous cervical lesions, according to researchers at Duke Medicine.

The findings, presented on Oct. 28, 2013, at the 12th annual International Conference on Frontiers in Cancer Prevention Research hosted by the American Association for Cancer Research, suggest that African-American women may be less likely to benefit from available HPV vaccines to prevent cervical cancer.

HPV is a common sexually transmitted infection with more than 40 subtypes. The virus causes nearly all cases of cervical cancer, which begin as precancerous cervical abnormalities. Two vaccines currently available to young women prevent infection by HPV 16 and HPV 18, the HPV strains responsible for about 70 percent cervical cancers.

"Screening programs for cervical cancer are known to work well, with around 90 percent of sexually active women getting screened through Pap tests," said senior author Cathrine Hoyo, Ph.D., M.P.H., associate professor of obstetrics and gynecology at Duke University School of Medicine.

"The question is, if screening rates are comparable in African-American and white women, why are the rates of cervical cancer and mortality higher among African-American women when we have a program that works so well?"

Hoyo and her colleagues sought to better understand these disparities by determining if African-American and white women in the U.S. are infected with the same subtypes of HPV. The researchers enrolled 572 participants -- 280 African-American women and 292 non-Hispanic white women -- who came for additional testing after receiving abnormal Pap test results.

Of the 572 participants, 245 (43 percent) had no precancerous cervical abnormalities, 239 (42 percent) had early precancerous cervical abnormalities, and 88 (15 percent) had advanced precancerous cervical abnormalities. Seventy-three percent of the women infected with HPV were infected with multiple HPV subtypes.

When the researchers looked at the specific strains of HPV, they found that white women and African-American women were often infected with different subtypes. The most frequent HPV subtypes detected among white women with early precancerous cervical abnormalities were 16, 18, 56, 39 and 66, while HPV subtypes 33, 35, 58 and 68 were the most common ones detected in African-Americans.

In those with advanced precancerous cervical abnormalities, HPV 16, 18, 33, 39 and 59 were the most common genotypes detected in white women, whereas HPV 31, 35, 45, 56, 58, 66 and 68 were the most prevalent in African-American women.

"Compared with white women, we saw that African-American women had about half as many infections with HPV 16 and 18, the subtypes that are covered by HPV vaccines," said Adriana Vidal, Ph.D., assistant professor of obstetrics and gynecology at Duke University School of Medicine and the study's first author. "Since African-American women don't seem to be getting the same subtypes of HPV with the same frequency, the vaccines aren't helping all women equally."

A new HPV vaccine targeting nine HPV subtypes (6, 11, 16, 18, 31, 33, 45, 52 and 58) is currently being tested in phase III trials. While the new vaccine may help prevent additional HPV infections by covering new subtypes, it may not address the disparities found in this study.

"The most disconcerting part of this new vaccine is it doesn't include HPV 35, 66 and 68, three of the strains of HPV of which African-American women are getting the most," Hoyo said. "We may want to rethink how we develop these vaccines, given that African-Americans tend to be underrepresented in clinical trials."

The researchers noted that while these findings are compelling, the results are preliminary and the studies should be replicated in larger populations. Hoyo, Vidal and their colleagues are also continuing the research to define epigenetic marks that can be used to predict which precancerous cervical abnormalities will advance.


Contact: Rachel Harrison
Duke University Medical Center

Related medicine news :

1. Beautiful New Strains of Nevil’s Medical Marijuana Seeds and Reeferman Medical Marijuana Seeds Now Available Online from R.M.S.S.
2. MedMar Healing Center, Taking Clone Pre-Orders for High-Quality Medical Marijuana Strains
3. Prediction of seasonal flu strains improves chances of universal vaccine
4. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
5. Some Whooping Cough Strains Now Outsmarting Vaccine
6. Infection With 2 HIV Strains Slows Disease Progression
7. Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains
8. Test links strains of common parasite to severe illness in US newborns
9. According to the United Health Foundation, The Burden of Diabetes in Missouri is on the Rise, Affecting Over Ten Percent of Residents
10. Southwestern Ear, Nose & Throat Associates Offers Guidelines On Hearing Loss, Lack of Sleep Affecting Back-to-School Health
11. American Medical Association Defines Obesity as a Disease Affecting 90 Million Americans
Post Your Comments:
(Date:12/1/2015)... ... , ... Growth in medical payments per workers’ compensation claim in Louisiana slowed ... nonhospital care, according to a recent study by the Workers Compensation Research Institute (WCRI). ... medical payments per claim with more than seven days of lost time continued to ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... medical images have been lifted as IMAGE Information Systems launches MED-TAB™ -- the ... North America Annual Meeting from November 29 to December 4, 2015. , ...
(Date:12/1/2015)... ... December 01, 2015 , ... Visage accelerates mobile imaging results ... subsidiary of Pro Medicus Ltd. (ASX: PME), has announced they are demonstrating new ... America (RSNA) 2015 annual meeting through December 3 in Chicago, Illinois, at Booth ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... clinical solutions for the care management and population health arenas, is pleased to ... clinical and cost containment services, has successfully implemented the ACUITY Complete Care™ Management ...
(Date:12/1/2015)... ... ... Nurotron Biotechnology Co., Ltd., maker of cochlear implant systems, has won a ... will be from the China Disabled Persons’ Federation, a central government association, for nearly ... children and adults suffering from severe and profound hearing loss . The company ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)...  Today, AmerisourceBergen, a global healthcare ... first-of-its-kind population health management program focused on the ... be built into existing employer benefit packages, CareFront ... their care and explains how to avoid unnecessary ... help patients understand their treatment options and financially ...
(Date:12/1/2015)... DUBLIN , Dec. 01, 2015 ... addition of the "Medical Alert Systems/Personal Emergency ... and by Geography - Global Forecas" report ... has announced the addition of the "Medical ... Type, by End-User and by Geography - Global ...
(Date:12/1/2015)... ) has ... Technology Market 2015 - Forecast to 2020" ... ) has announced the addition of the ... 2020" report to their offering. --> ... announced the addition of the "Drug Delivery ...
Breaking Medicine Technology: