Navigation Links
HPV screen-and treat-intervention effective in cervical cancer prevention
Date:9/30/2010

Women in South Africa who underwent human papillomavirus (HPV) DNA-based testing or visual inspection of the cervix followed by treatment of test-positive women with cryotherapy had a statistically significant reduction in high grade cervical cancer precursors, compared with women in a control group, according to a study published online Sept. 30 in The Journal of the National Cancer Institute.

In many developing countries, especially in sub-Saharan Africa, cytology-based screening is unavailable. To counter this lack of availability, non-cytological screening methods such as DNA testing or visual inspection of the cervix have been developed, methods that do not require the same laboratory infrastructure as cytology and allow for the immediate treatment of women with detected lesions. The approach of screening using non-cytological methods and then treating all test positive women is referred to as "screen-and-treat" and access to such cervical cancer prevention programs may be able to reduce cervical cancer mortality where cytology-based screening is unavailable.

To determine whether HPV DNA-based screening and visual inspection of the cervix reduced cervical cancer, Thomas C. Wright, M.D., of Columbia University, and colleagues, conducted a randomized trial of 6637 unscreened South African women aged 35-56 years, who were assigned to three study arms: HPV DNA screen-and-treat, in which women with a positive HPV test, VIA screen-and-treat in which women with a positive visual inspection test underwent cryotherapy; or a control group, in which further evaluation and treatment were delayed for 6 months. The researchers tested the women for 36 months, and measured cervical cancer lesions of grade two or worse, also known as CIN 2+ for cervical intraepithelial neoplasia.

The researchers found that after 36 months of follow-up, the women who developed CIN2+ included 1.5% in the screen-and-treat arm, 3.8% in the visual inspection-and-treat arm, and 5.6% in the control arm. The authors write, "This study demonstrates that an HPV DNA-based screen-and-treat program for cervical cancer is highly effective and produces a durable reduction in CIN 2+."

Furthermore, they write: "These results suggest that cryotherapy may have long-term implications for low-resource settings where it is difficult and costly to re-screen women at regular intervals."

In an accompanying editorial, Julia C. Gage and Philip E. Castle of the National Cancer Institute write that the advent of accurate low-cost HPV DNA testing bodes well for women in low-income settingsprovided political will and monetary investment accompany technological advancement. "With low-cost accurate HPV screening tests coming online, cervical cancer prevention is becoming more effective, affordable, and feasible for low-resource settings," they write.


'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Testing African couples for HIV is cost-effective prevention strategy
2. Correction: Abatacept found ineffective in treatment of non-life threatening lupus
3. Wider statin use could be cost-effective preventive measure, Stanford study finds
4. Surgery found effective for patients with aggressive prostate cancer
5. IV Aspirin Drip Appears to Be Safe, Effective for Migraine
6. Centralized health care more cost-effective, offers better access to preventive services
7. Parents report a widely prescribed antibiotic is effective for fragile X treatment
8. Addressing negative thoughts most effective in fighting loneliness
9. Double-therapy approach effectively inhibited brain cancer recurrence
10. Drug-eluting stents confirmed safe, effective for long-term use
11. Trauma center care cost-effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. ... 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine ... visits to the dentist fit into their patients’ busy lifestyles. Dental365 also gladly ...
(Date:6/23/2017)... ... 2017 , ... "The Better Care Reconciliation Act (BCRA) falls ... people with all chronic conditions, including mental illnesses, while increasing the cost of ... Care Act (ACA) requirement that insurers cover pre-existing conditions, it does not require ...
(Date:6/23/2017)... ... 2017 , ... The Military Officers Association of America (MOAA) announced its support ... retired Marine Col. Thomas G. Bowman. , Bowman currently serves as the staff director ... with the issues and challenges veterans face with the VA. Following a 30-year career ...
(Date:6/23/2017)... ... June 23, 2017 , ... Goodcents Deli Fresh Subs today announced the opening ... 4210 SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned ... owns three other locations in the Topeka and Bonner Springs, Kan. area. , ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South ... selected 21 leaders from government, business and civil society in 11 countries across the ... this fall, engaging in a transformative exchange of knowledge and ideas with the leading ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)...  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, Inc. ... Iowa location. The Iowa ... an ISO 7 cleanroom—the standard needed to compound intravenous (IV) nutrition ... of pollutants. "Our new cleanroom ... serve our Iowa patients," said Phil ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
(Date:5/26/2017)... 2017  Endo International plc (NASDAQ: ENDP ) ... will represent the Company in a fireside chat at Goldman ... June 13, 2017 at 10:40 a.m. PT / 1:40 p.m. ... Rancho Palos Verdes, CA. ... be available on the Company,s website at http://www.endo.com/investors/overview . ...
Breaking Medicine Technology: