Navigation Links
HPV-positive SCCOP patients' recurrence differs from HPV-negative patients
Date:2/20/2014

Scottsdale, Ariz., February 20, 2014Patients with HPV-positive squamous cell carcinoma of the oropharynx (SCCOP) had a longer time to development of distant metastasis (DM) after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

Culled from records of an IRB-approved registry, the study reviewed 285 patients with stage III-IV SCCOP (originally thought to be a smoking-related head and neck cancer) treated with chemotherapy and radiation from 2002 to 2013. HPV status was determined by in situ hybridization for HPV DNA and/or by strong and diffuse (>75 percent) staining for p16 immunohistochemistry. There were 245 HPV-positive and 40 HPV-negative patients.

Twenty-seven HPV-positive and eight HPV-negative patients failed with DM and were the subjects for more detailed evaluation. Radiation therapy (RT) was either 3-D RT (HPV-positive = 15/27; HPV-negative = 4/8) or intensity modulated radiation therapy (IMRT) (HPV-positive = 12/27; HPV-negative = 4/8) with doses from 66-79 Gy. Patients received concurrent chemotherapy of cisplatin (HPV-positive = 9/27; HPV-negative = 2/8), cisplatin/5 fluorouracil (FU) (HPV-positive = 10/27; HPV-negative = 3/8) or cetuximab (HPV-positive = 8/27; HPV-negative = 2/8). One HPV-negative patient received cisplatin/paclitaxel chemotherapy. One patient in each group was treated with adjuvant chemoradiotherapy after initial resection. Student t-tests were used to compare the difference between the means of the samples.

Both HPV-positive and HPV-negative patients were found to have similar rates of DM, however the mean time to develop DM was significantly longer for HPV-positive patients (HPV-positive = 21.6 months vs. HPV-negative = 7.0 months). The most common sites of metastasis for all patients were the lung (HPV-positive = 17/27 vs. HPV-negative = 5
'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers investigate a less toxic radiation treatment for HPV-Positive oropharynx cancer
2. Feasible, safe to limit radiation to major salivary glands in head and neck cancer patients
3. Patients with oropharyngeal cancer report quality of voice and speech affected post-treatment
4. MATH, HPV status in HNSCC patients effective markers of improved patient outcome
5. Researchers look for culprit behind oral health problems in HIV-positive patients
6. Hypnosis therapy shown to decrease fatigue levels in breast cancer patients
7. Bevacizumab (Avastin) fails to improve survival for newly diagnosed glioblastoma patients
8. Blood test serves as crystal ball for heart transplant patients, UCLA-led study finds
9. New treatment proposed to prevent intestinal inflammation in cancer patients
10. One-quarter of high risk patients denied anticoagulation after AF ablation
11. Transgender patients discriminated against for health care services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of Cruz Chiropractic ... treated just about every type of injury that can result from ... same twenty-plus years, the team at Doctors on Liens ... possible doctor. With the combined breadth of experience between ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Compare-autoinsurance.org has released a ... insured by an auto insurance policy . , Some ... policy. Clients should check the newly released blog post to see ... cars and dangerously damaged vehicles are some of the cars that ...
(Date:12/26/2014)... 2014 The US represents the largest market ... 2013, GlobalData’s forecast estimates that sales of branded therapies were ... to the high incidence of the disease, high drug treatment ... and China. Increased sales of CRC therapies over the forecast ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... Christine Mummery, one of the worlds leading heart stem cell ... Dame Anne McLaren in the keynote lecture of the inaugural ... McLaren was an early pioneer of the study of embryonic ... of IVF treatments and stem cell techniques. , Prof Mummery ...
... natural fatty acids that is sometimes used as a weight-loss ... substances to prevent health problems that can follow rapid weight ... a compound naturally found in some meat and dairy products, ... a recent study in mice found that the hormone leptin ...
... to Complement Renowned Laboratory Information System, ... Inc. (OTC Bulletin Board: GLOB), an international,e-Health, ... its,Wyndgate Technologies(R) (Wyndgate) division has formed a ... CERN ), a,leading provider of healthcare ...
... MIAMI, April 9, 2008 Eurosport Active World, ... World, Corp. and,Eagle International Holdings Group, Inc. have ... Corp., whose common stock,trades on the "Pink Sheets" ... Inc. have merged. Subsequent to a 1000:1 reverse ...
... could be missed, harming long-term survival, study suggests , , ... analysis of breast cancer patient survival suggests it might ... node biopsies. , A team of New York City ... to be free of cancerous cells in their sentinel ...
... April 9, 2008 /Xinhua-PRNewswire-FirstCall/ -- Mindray,Medical International Limited ... marketer of medical devices in China with a ... Cheng, Mindray,s,executive vice president of strategic development and ... the JPMorgan 4th Annual China,Conference to be held ...
Cached Medicine News:Health News:Heart stem cell scientist to honor pioneering woman scientist in keynote speech 2Health News:Dietary oil may need help in avoiding any side effects of weight loss 2Health News:Dietary oil may need help in avoiding any side effects of weight loss 3Health News:Global Med Technologies(R), Inc. and Cerner Announce Strategic Alliance 2Health News:Global Med Technologies(R), Inc. and Cerner Announce Strategic Alliance 3Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 2Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 3Health News:Breast Cancer Lymph Node Biopsy May Need Closer Look 4Health News:Mindray to Attend the JPMorgan 4th Annual China Conference 2
(Date:1/23/2015)... Jan. 23, 2015   Leatt Corporation  (OTCQB: LEAT), a ... for all forms of sports, including extreme motor sports, ... announced today that the UISP Lega Motociclismo Lombardia, an ... riders to wear a neck brace during its racing ...
(Date:1/23/2015)... , Jan. 23, 2015 Tianyin Pharmaceutical Inc. (NYSE ... specializes in the development and sale of patented biopharmaceutical ... active pharmaceutical ingredients (API) today announced the business and ... operation. 1. Following the September 2014 JCM ...
(Date:1/22/2015)... - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a ... cardiovascular disease and overall health is pleased to provide you ... its outlook for 2015 from the CEO, Mr. Eugene ... would like to take this opportunity to share with you ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... The Calypte AwareTM HIV-1/2 OMT test ... in vitro immunoassay for the,detection of antibodies ... and Type 2 (HIV-2) in human oral,mucosal ... as a point-of-care aid in the clinical ...
... the first HbA1c control available with intact ... HbA1c procedure including the lysing of the ... ready-to-use liquid control with an open-vial stability ... of six months when refrigerated. A1c-Cellular is ...
...
...
Medicine Products: