Navigation Links
HPV-positive SCCOP patients' recurrence differs from HPV-negative patients
Date:2/20/2014

Scottsdale, Ariz., February 20, 2014Patients with HPV-positive squamous cell carcinoma of the oropharynx (SCCOP) had a longer time to development of distant metastasis (DM) after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

Culled from records of an IRB-approved registry, the study reviewed 285 patients with stage III-IV SCCOP (originally thought to be a smoking-related head and neck cancer) treated with chemotherapy and radiation from 2002 to 2013. HPV status was determined by in situ hybridization for HPV DNA and/or by strong and diffuse (>75 percent) staining for p16 immunohistochemistry. There were 245 HPV-positive and 40 HPV-negative patients.

Twenty-seven HPV-positive and eight HPV-negative patients failed with DM and were the subjects for more detailed evaluation. Radiation therapy (RT) was either 3-D RT (HPV-positive = 15/27; HPV-negative = 4/8) or intensity modulated radiation therapy (IMRT) (HPV-positive = 12/27; HPV-negative = 4/8) with doses from 66-79 Gy. Patients received concurrent chemotherapy of cisplatin (HPV-positive = 9/27; HPV-negative = 2/8), cisplatin/5 fluorouracil (FU) (HPV-positive = 10/27; HPV-negative = 3/8) or cetuximab (HPV-positive = 8/27; HPV-negative = 2/8). One HPV-negative patient received cisplatin/paclitaxel chemotherapy. One patient in each group was treated with adjuvant chemoradiotherapy after initial resection. Student t-tests were used to compare the difference between the means of the samples.

Both HPV-positive and HPV-negative patients were found to have similar rates of DM, however the mean time to develop DM was significantly longer for HPV-positive patients (HPV-positive = 21.6 months vs. HPV-negative = 7.0 months). The most common sites of metastasis for all patients were the lung (HPV-positive = 17/27 vs. HPV-negative = 5
'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers investigate a less toxic radiation treatment for HPV-Positive oropharynx cancer
2. Feasible, safe to limit radiation to major salivary glands in head and neck cancer patients
3. Patients with oropharyngeal cancer report quality of voice and speech affected post-treatment
4. MATH, HPV status in HNSCC patients effective markers of improved patient outcome
5. Researchers look for culprit behind oral health problems in HIV-positive patients
6. Hypnosis therapy shown to decrease fatigue levels in breast cancer patients
7. Bevacizumab (Avastin) fails to improve survival for newly diagnosed glioblastoma patients
8. Blood test serves as crystal ball for heart transplant patients, UCLA-led study finds
9. New treatment proposed to prevent intestinal inflammation in cancer patients
10. One-quarter of high risk patients denied anticoagulation after AF ablation
11. Transgender patients discriminated against for health care services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... “Every three months the trends for ... evening dress will be one of the hottest styles in ... says. Today, the company releases 26 A-line sweetheart evening dresses, ... off. , “We are trying our best to help ... latest designs. Along with affordable prices, we provide discounted delivery ...
(Date:12/25/2014)... 26, 2014 Recently, iFitDress.com, the popular online ... has announced its new selection of black one-shoulder cocktail ... sale now; they are available at discounted prices, up to ... promotion will last for three weeks only. You know, we ... who are interested in our new items can visit our ...
(Date:12/25/2014)... 26, 2014 Recently, Dylan Queen, a ... excitedly released its collection of discounted prom dresses, most ... a senior spokesman of the company, the promotion is ... promotion is to expand the UK market. , The ... different colors, lengths, and styles: A-line strapless, empire strapless ...
(Date:12/25/2014)... Los Angeles, CA (PRWEB) December 25, 2014 ... Blaise Dolcemaschio was created in honor of a true ... premiere at two film festivals including the 24 hours of ... Film Festival in Bangladesh. , Actress, screenwriter and ... and helped produce this film together with her husband, ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3
... Kabi Pty Ltd, one of Australia,s fastest growing and ... (Robotic IV Automation) - a self-contained unit for filling ... (IH Systems) to consolidate its IV preparation. Pharmatel Fresenius ... in June 2009. , The RIVA System and Pharmatel ...
... Feb. 11 Naturs Design, Inc., a privately held ... the revolutionary product that virtually eliminates all of the ... for sleep apnea. Unfortunately, CPAP therapy hasn,t always been ... reports that "many CPAP users never continue therapy beyond ...
... Gynecologic Oncologists, 40th Annual Meeting on Women,s Cancer Proves ... Pa., Feb. 11 New data presented on Saturday ... Oncologists, 40th Annual Meeting on Women,s Cancer demonstrated the ... CA125 blood test results and the Risk of Ovarian ...
... 11 Rising Medical Solutions, Inc. (Rising), ... management organization, announced today that it has ... Accreditation from URAC, a Washington, DC-based health ... quality standards for the health care industry.(Logo: ...
... announced today that Laurence Debroux is ... (CSO).In light of the implementation of the Group,s ... the position of Chief Strategic Officer at the ... business development and acquisition activities as well as ...
... Feb. 11 The Quantum Group, Inc. ( NYSE ... that Pete Martinez, Senior Vice President and Chief Technology ... the St. Thomas University Healthcare Seminar later ... Economic Times." Martinez will contribute to the event ...
Cached Medicine News:Health News:Australia's Leading Oncology Drug Compounder Chooses RIVA System 2Health News:Husband From Small Town May Have Found Solution to Sleep Industry's 20-Year Compliance Problem 2Health News:Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer 2Health News:Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer 3Health News:Rising Medical Solutions Receives URAC Workers' Compensation Utilization Management Accreditation 2Health News:Rising Medical Solutions Receives URAC Workers' Compensation Utilization Management Accreditation 3Health News:Laurence Debroux Appointed Chief Strategic Officer (CSO) 2Health News:Quantum Executive Pete Martinez Invited to Participate in University Health Seminar 2Health News:Quantum Executive Pete Martinez Invited to Participate in University Health Seminar 3Health News:Quantum Executive Pete Martinez Invited to Participate in University Health Seminar 4
(Date:12/24/2014)... , Dec. 24, 2014 /CNW/ - ... is being recalled after Health Canada tests confirmed it ... health risks (beta-methylphenethylamine and phenylpropylmethylamine). The distributor, Empire Health ... recalling the product from retail stores across ... building purposes, including for weight loss and increased energy. ...
(Date:12/24/2014)... Dec. 24, 2014  Novastem, a leader in ... patient in its study for ischemic stroke at ... Association, ischemic strokes account for 87 percent of ... patients in the study, entitled "Internal Research Protocol ... Mesenchymal Stem Cells and Intrathecal Administration of Neural ...
(Date:12/24/2014)... -- Actavis plc (NYSE: ACT ) today ... response letter from the U.S. Food and Drug ... for the fixed-dose combination (FDC) of nebivolol and ... Photo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO ... a complete response letter, Actavis remains committed to ...
Breaking Medicine Technology:"Jetfuel Superburn" recalled after Health Canada tests find undeclared drug ingredients 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4
... Corporation (NYSE: SYK ) reported operating results for ... Third Quarter Highlights Net sales ... to $1,768 million Orthopaedic Implants sales increased 1.3% on ... Equipment sales increased 16.3% on a constant currency basis (16.1% ...
... Calif., Oct. 19 ThermoGenesis Corp. (Nasdaq: ... services that process and store adult stem cells, said ... agreement for its Res-Q™ 60 BMC (Res-Q) System with ... point-of-care cardiovascular therapies. Under the agreement, ...
Cached Medicine Technology:Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 2Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 3Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 4Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 5Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 6Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 7Stryker Reports 7% Sales Growth, 14% Adjusted Net Earnings Growth for Quarter Ended September 30, 2010 8ThermoGenesis Announces Platelet Rich Plasma (PRP) Res-Q Cardiovascular Licensing Agreement 2ThermoGenesis Announces Platelet Rich Plasma (PRP) Res-Q Cardiovascular Licensing Agreement 3
For children up to 4 years of age 11 mm internal diameter of the cornea part. Designed to work with argon/YAG Lasers....
... capture and management system that acquires extremely ... Angiography images. It interfaces with most current ... from any ophthalmic device with video, digital ... the features of EyeCap RI, with further ...
The Haag-Streit 81 D lens is a powerful tool for biomicroscopy as well as laser treatment of the fundus. Due to its asymmetric configuration it provides better observation parameters combined with im...
... mirrored surfaces, which each incline at an ... have been cut into the 17 mm ... to examine the opposite iridocorneal angle without ... form of the angle of the iris ...
Medicine Products: