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HPV-associated cancer incidence rates point to needed efforts to increase HPV vaccination coverage
Date:1/7/2013

Despite the decline in cancer death rates in the U.S., there is an increase in incidence rates for cancers associated with human papillomavirus (HPV) infection and more efforts are needed to increase HPV vaccination coverage levels to prevent the occurrence of these cancers in the future according to a study published January 7 in the Journal of the National Cancer Institute.

The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) annually provide updates on trends in cancer incidence and death rates in the United States. This year's report highlighted trends in incidence rates for HPV associated cancers and HPV vaccination coverage levels. Two HPV vaccines (bivalent and quadrivalent) have been shown to protect against most cervical cancers in women and one vaccine (quadrivalent) also protects against genital warts and cancers of the anus, vagina and vulva. There is no data available on vaccine efficacy for prevention HPV-associated cancers of the oropharynx.

In order to assess trends in HPV-associated cancer incidence rates and HPV vaccination coverage levels, Ahmedin Jemal, D.V.M., Ph.D., Surveillance Research Program, American Cancer Society, Atlanta, GA., and colleagues examined cancer incidence data reported by the CDC, and NCI, through NAACCR, as well as cancer mortality data from the CDC. The researchers determined trends in age-standardized incidence and death rates for all cancers combined and for the leading cancers among men and women, while HPV vaccination coverage levels during 2008 and 2010 and the prevalence of Papanicolaou (Pap) testing during 2010 were obtained from national surveys.

During 2000-2009, the researchers found that overall cancer death rates in the U.S. continue to decrease (including for lung, colorectal, female breast, and prostate cancers), but that de
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Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

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