Navigation Links
HPV-Linked Oral Cancers on the Rise, Study Finds
Date:10/3/2011

By Serena Gordon
HealthDay Reporter

MONDAY, Oct. 3 (HealthDay News) -- The rate of oral cancers linked to the sexually transmitted human papillomavirus (HPV) rose dramatically over two decades, according to new government research.

Within a decade, these types of tumors might become the leading form of HPV-linked cancers, the researchers noted.

In the period between 1984 and 1989, just 16.3 percent of oral cancer samples tested positive for HPV. By 2000 to 2004, that number had jumped to 72 percent, the researchers found.

"Back in 2008, we did a study and found that the incidence rates of oropharyngeal cancers have increased. Because this increase occurred in a period where cigarette smoking has decreased, we hypothesized that another risk factor -- perhaps HPV -- might be responsible," explained the study's lead author, Anil Chaturvedi, an investigator in the division of cancer epidemiology at the U.S. National Cancer Institute.

"We found that the prevalence of HPV infection significantly increased over time," said Chaturvedi.

Results of the study were published online Oct. 3 in the Journal of Clinical Oncology.

HPV is a sexually transmitted virus known to cause cervical cancers. The authors suggest that the current rise in oral HPV may be due to an increase in oral sex.

There's currently a vaccine available to prevent infection with certain types of HPV. It's not known, however, if this vaccine could also prevent oral infections with HPV.

For the current study, the researchers tested samples from 271 oropharyngeal cancers that occurred between 1984 and 2004. The tumor samples came from Hawaii, Iowa and Los Angeles, according to the study.

The investigators tested for a specific strain of HPV known as HPV16. This particular type of HPV is also known to cause cervical cancers, and is one of the strains covered by the cervical cancer vaccine.

Just 16.3 percent of samples taken in the 1980s tested positive for HPV16, compared with nearly 72 percent of those taken in the early 2000s, the study authors reported.

That means in the late 1980s, about 0.8 per 100,000 people had HPV-linked oropharyngeal cancer and by 2004, 2.6 per 100,000 had such a cancer. That's an increase of 225 percent, the authors explained.

During that same time, HPV-negative oral cancers -- most likely caused by tobacco or alcohol use -- declined by 50 percent, according to the study.

"By the year 2020, HPV-positive oropharyngeal cancers will be the most common HPV-related cancer," said Chaturvedi. He noted that while a lot of progress has been made in preventing HPV-related cervical cancer, research in HPV-related oral cancers is currently lacking.

"HPV is a major cause of oropharyngeal cancers, and we need to understand the natural history of oral HPV infections and what the modifiable risk factors are. Clinical studies are also needed to see if specific targeted therapies can help oropharyngeal cancer patients," he said.

Dr. Jeffrey S. Weingarten, an otolaryngologist with the St. John Providence Health System in Southfield, Mich., agreed that further research needs to be done.

"It is possible that fewer HPV infections in women [due to the vaccine] will result in fewer infections in men," he said, adding that if the vaccine turns out to be effective in men, there may be an additional reduction in HPV infections.

Chaturvedi said that "it's anticipated that the [currently available HPV] vaccines would have a high efficacy in males," but that only clinical trials can answer this question for sure.

More information

Learn more about risk factors for oral cancers from the American Cancer Society.

SOURCES: Anil Chaturvedi, Ph.D., investigator, infections and immunoepidemiology branch, division of cancer epidemiology, U.S. National Cancer Institute, Rockville, Md.; Jeffrey S. Weingarten, M.D., otolaryngologist, St. John Providence Health System, Southfield, Mich.; Oct. 3, 2011, Journal of Clinical Oncology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Researchers chart genomic map spanning over 2 dozen cancers
3. Scientists Spot Genetic Fingerprints of Individual Cancers
4. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
5. Proton beam therapy shows encouraging long-term outcome for patients with locally advanced sinonasal cancers
6. Herceptin and Tykerb effective against a subset of gastric cancers
7. Poniard Pharmaceuticals Presents Positive Survival Data from a Phase 2 Clinical Study of Picoplatin in Metastatic Prostate Cancer at the 2010 American Society of Clinical Oncology Genitourinary Cancers Symposium
8. Exploiting the architecture of cancers may lead to their destruction
9. Palpable breast cancers are more common in women not undergoing annual mammography
10. Non-Melanoma Skin Cancers in the Millions and Rising
11. Virtual colonoscopy allows detection of unsuspected cancers beyond colon
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
HPV-Linked Oral Cancers on the Rise, Study Finds
(Date:9/20/2017)... Texas (PRWEB) , ... September 20, 2017 , ... ... in the Orthodontics and Clear Aligner clinical and commercial support services market) has ... of Dentistry (PGSD) in Sydney, Australia. , The PGSD is the first ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... In just ... Brain Booster has already been receiving positive feedback from customers trying the product for ... , Daily Brain Booster was developed by neurosurgeon Shawn Moore, MD, for everyone ...
(Date:9/20/2017)... , ... September 20, 2017 , ... ... of older Americans at risk of price gouging for their prescription drugs, according ... (TSCL) . “Because Medicare isn’t negotiating on our behalf, there’s no consistency in ...
(Date:9/20/2017)... ... , ... “RECYCLED Ezekiel's Plan for Freedom from ADDICTION”: A ... is the creation of published author, Bill Miller. Bill Miller has a ... more than a decade of addiction to prescription drugs. He has a ...
(Date:9/20/2017)... , ... September 20, 2017 , ... “Psalms of Humidity”: ... peace of mind and move the readers one step closer to God. “Psalms of ... realized that his mistakes that have been made within his life are the very ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
(Date:9/5/2017)... N.J. , Sept. 5, 2017  Getinge, ... has created a vibrant charitable donation program -- ... and support congenital heart defect research by The ... providers and the general public are encouraged to ... and submit the completed artwork to the gallery ...
(Date:9/1/2017)... 1, 2017  Bayer will present the latest research from ... Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... preclinical and clinical data on Bayer,s marketed portfolio and late-stage ... "We value the ... cancer research at ESMO," said Carsten Brunn , Head ...
Breaking Medicine Technology: