Navigation Links
HOXB7 gene promotes tamoxifen resistance
Date:12/10/2010

A gene target for drug resistance, a triple-drug cocktail for triple negative breast cancer, and patients' risk for carpal tunnel syndrome are among study highlights scheduled to be presented by Johns Hopkins Kimmel Cancer Center scientists during the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12. The information is embargoed for the time of presentation at the symposium.

HOXB7 GENE PROMOTES TAMOXIFEN RESISTANCE
(Presentation # PD05-10)

Many postmenopausal women with early-stage breast cancers who initially respond well to tamoxifen become resistant to the drug over time and develop recurrent tumors. Johns Hopkins Kimmel Cancer Center researchers have found that a gene called HOXB7 may be the culprit in tamoxifen resistance.

Taken by mouth, tamoxifen is used at every stage of breast cancer to treat existing tumors and prevent new ones from developing. The drug works only in women whose tumor cells have a protein, called the estrogen receptor, which binds to the estrogen hormone. Tamoxifen binds to this estrogen receptor and blocks estrogen's effect on fueling cancer cells.

In experiments on cancer cells, the scientists found that when the HOXB7 gene is overexpressed, as occurs in many breast cancers, tumors cells became resistant to tamoxifen. Overexpression of HOXB7 results in proteins that interact with a series of other estrogen-activated genes and proteins, including the HER2 gene, known to make breast cancers aggressive. When the scientists knocked out the HOXB7 gene in one group of breast cancer cells, HER2 activation decreased and the cells became more responsive to tamoxifen. The scientists then showed how the HOXB7-HER2 interaction works.

"HOXB7 appears crucial in orchestrating estrogen receptors, HER2 and other receptors that promote aggressive tumor growth in breast cancer cells," says senior author Saraswati Sukumar, PhD, professor of oncology and co-director of
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Difficult Dialogues Initiative promotes diversity at MU, around country
2. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
3. New Anti-Aging Skin Care Line Promotes Penetration
4. Brain Health Expert Says OASIS Promotes Brain Fitness
5. Microfluidics Promotes Scientific University Research Using Nanotechnology with Innovation Incentives
6. Scientists find key to gene that promotes cancer metastasis
7. Scientific exchange program promotes collaborative quality standards for drugs, food ingredients
8. Pinstripe Promotes Jill Schwieters to President of Pinstripe Healthcare
9. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
10. Medical Transcription Services and EHR Provider MxSecure Promotes Tim Erkel to VP, Client Services
11. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... ERISAPros is pleased to announce ... the professional staff of its Compliance Department. , Evelyn ... State University-Mortiz College of Law. Prior to joining ERISAPros, ... several Fortune 500 companies as well as several privately ... Her experiences range from benefit plan design, vendor management, ...
(Date:2/28/2015)... 28, 2015 In recent years Medical Marijuana ... practicing physicians as a way for them to expand their ... Cannabis as medicine. Since the FDA still lists Cannabis as ... available to licensed physicians that can help guide them ... Deborah Malka in Santa Cruz, CA is a leader ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 The Heart ... now a distributor of the machine. The Heart Fit ... their license, like a franchise model. The goal is ... and reverse heart disease. To buy External Counterpulsation ... Clinic can help individuals through this process and achieve ...
(Date:2/28/2015)... Fredericton, NB (PRWEB) February 28, 2015 ... call center software suite for Asterisk, are pleased to ... the highly successful 5.7 and 5.8 versions of Q-Suite, ... as well as a number of new features to ... be Q2 2015. , Q-Suite 5.9 will add features ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 ... of outsourced sales, marketing and supply chain management ... BIOTA Botanicals, is bringing its award winning solutions ... BIOTA Botanicals’ products are specifically created to combat ... experts, BIOTA is committed to marrying science with ...
Breaking Medicine News(10 mins):Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3
... Save the Children By Charles ... WESPORT, Conn., Oct. 24 The dramatic images,of wildfires ... on,children not only in the immediate area where the ... country who are watching the,destructive power of the flames ...
... Company Becomes First to Leverage Zagat,s, Expertise to Survey ... Rate Experiences Using ... Oct. 24 WellPoint, Inc., the,nation,s largest health benefits ... of a new online survey tool that will allow,consumers ...
... Pennsylvania has reversed the medical malpractice trend, ... said that Medical Care Availability and Reduction of ... since he took office and, as,a result of ... "Pennsylvania is a success story when it ...
... a novel,medical humidifier, was awarded a prestigious R&D ... PARI Innovative Manufacturers, a leading,manufacturer of nebulizers and ... gases are heated and humidified with the aim ... greater control,of patient comfort. The award, selected ...
... -- Combat physicians in war-torn areas like Iraq and ... require massive blood transfusions (MT), and thereby increase a ... the October issue of The Journal of the American ... of a combination of three variables -- assessed immediately ...
... induced in healthy volunteers, according to a study by ... Center for Medical Cannabis Research (CMCR.) However, the ... the placebo controlled study of 15 subjects, a low ... provided moderate pain relief, and a high dose increased ...
Cached Medicine News:Health News:How to Help Children Cope With the California Wildfires 2Health News:How to Help Children Cope With the California Wildfires 3Health News:How to Help Children Cope With the California Wildfires 4Health News:WellPoint Taps Zagat Survey to Help Consumers Rate Experiences with Their Doctors 2Health News:WellPoint Taps Zagat Survey to Help Consumers Rate Experiences with Their Doctors 3Health News:Governor Rendell Says Mcare Claims and Costs Are 50 Percent Lower Than in 2003 2Health News:PARI's Hydrate Wins Prestigious R&D 100 Award 2Health News:Early predictive model may be new 'weapon' against leading cause of death on battlefield 2Health News:Smoked cannabis proven effective in treating neuropathic pain 2
(Date:2/27/2015)... -- Uroplasty, Inc. (NASDAQ: UPI ), a medical device ... to treat voiding dysfunctions, today announced that it will ... March 10, 2015. Rob Kill , President and ... will present at 4:00 p.m. Pacific Time and meet ... the Ritz Carlton in Laguna Niguel, CA. ...
(Date:2/27/2015)... 2015  Two mass spectrometry technologies MALDI ... their effectiveness is established, according to biotechnology ... says that while mass spectrometry (mass spec ... in proteomic biomarker discovery and validation, mass ... techniques has struggled to elucidate molecular distribution ...
(Date:2/26/2015)... 2015  Tandem Diabetes Care®, Inc. (NASDAQ: ... the t:slim® and t:flex™ Insulin Pumps, today announced the ... of its common stock at a price to the ... Tandem from this offering are expected to be $56.3 ... estimated offering expenses payable by Tandem. All of the ...
Breaking Medicine Technology:Uroplasty to Participate in the 27th Annual ROTH Conference 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 2Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 3
... 9, 2011 Vyatta , ... and cloud infrastructures, today announced that the Vyatta ... selected to provide HIPAA compliant network security for ... information technology to deploy scalable, collaborative healthcare networks ...
... AMBLER, Pa., Aug. 9, 2011 Allergy Technologies LLC, ... liners, is sponsoring a new bed bug research program at ... by the Company. This new endeavor will ... strategies relating to innovative bed bug treatment applications. The dramatic ...
Cached Medicine Technology:Vyatta Virtual Firewall Addresses HIPAA Compliance for Thrasys 2Allergy Technologies LLC Provides Over $100,000 in a Research Grant to The Ohio State University for the Study of Bed Bugs 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: