Navigation Links
HJF enters cooperative agreement to develop vaccine for staph infections
Date:12/17/2008

ROCKVILLE, MD, (Dec. 17, 2008)The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) has entered into a Cooperative Research and Development Agreement (CRADA) with the Uniformed Services University of the Health Sciences (USU) and Maryland-based Nabi Biopharmaceuticals to develop a vaccine that could prevent life-threatening staph infections.

HJF researchers at USU's Infectious Disease Clinical Research Program will work with Nabi scientists to develop a licensed pentavalent Staphylococcus aureus vaccine to prevent skin and soft tissue infection.

The CRADA proposes a series of clinical trials for Nabi's PentaStaph, a five-component vaccine that induces antibodies to target S. aureus capsular polysaccharides Types 5, 8 and the cell wall antigen Type 336, which enhances the immune system's ability to clear bacteria from the host.

PentaStaph also induces antibodies that target two of the most predominant and virulent toxins produced by the bacteria, Panton-Valentine Leukocidinfound predominantly in community-acquired methicillin-resistant Staphylococcus aureusand alpha toxin, produced by almost all S. aureus isolates. Those toxins can significantly debilitate the human immune system.

The first clinical trial will evaluate the safety and immunogenicity of the compounds designed to target Panton-Valentine Leukocidin and alpha toxin. The second will evaluate the safety and immunogenicity of the other three components of the vaccine. The third trial will evaluate the safety and immunogenicity of all five components.

"S. aureus infections adversely impact many active duty members and several phases of military operations, in addition to the well-being of U.S. citizens," said Dr. David Tribble, director of general infectious disease research at IDCRP. "We believe that investigating vaccine-based strategies is critical to prevent these common and serious infections both in military and civilian settings."


'/>"/>

Contact: JoAnn Sperber
jsperber@hjf.org
301-294-1234
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Related medicine news :

1. Dana Corporation, Inc. Enters Into Settlement Agreement With Dana Retiree Committee
2. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
3. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
4. Navitas Opens New Cancer Rehabilitation Center in Albuquerque in Conjunction With New Mexico Cancer Centers
5. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
6. Service-to-Sales Transformation at Contact Centers Hinges on Soft Skills
7. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
8. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
9. Commercial Insurers Reimbursement Rate to New Yorks Community Health Centers Jeopardizes Care
10. Pennsylvania Trauma Systems Foundation Accreditation Status for Trauma Centers
11. Vangent, Inc. Wins Spot on Centers for Medicare & Medicaid Services Enterprise System Development Contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm Forward ... Berkeley, and other leading institutions in announcing the launch of the Leadership ... the way animals are raised for food. , Founding members of the Leadership ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/12/2017)... EXTON, Pa. , Oct. 12, 2017 ... global leader in innovative solutions for injectable drug administration, ... results before the market opens on Thursday, October 26, ... discuss the results and business expectations at 9:00 a.m. ... 877-930-8295 (U.S.) or 253-336-8738 (International). The conference ID is ...
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
Breaking Medicine Technology: