Navigation Links
HJF enters cooperative agreement to develop vaccine for staph infections
Date:12/17/2008

ROCKVILLE, MD, (Dec. 17, 2008)The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) has entered into a Cooperative Research and Development Agreement (CRADA) with the Uniformed Services University of the Health Sciences (USU) and Maryland-based Nabi Biopharmaceuticals to develop a vaccine that could prevent life-threatening staph infections.

HJF researchers at USU's Infectious Disease Clinical Research Program will work with Nabi scientists to develop a licensed pentavalent Staphylococcus aureus vaccine to prevent skin and soft tissue infection.

The CRADA proposes a series of clinical trials for Nabi's PentaStaph, a five-component vaccine that induces antibodies to target S. aureus capsular polysaccharides Types 5, 8 and the cell wall antigen Type 336, which enhances the immune system's ability to clear bacteria from the host.

PentaStaph also induces antibodies that target two of the most predominant and virulent toxins produced by the bacteria, Panton-Valentine Leukocidinfound predominantly in community-acquired methicillin-resistant Staphylococcus aureusand alpha toxin, produced by almost all S. aureus isolates. Those toxins can significantly debilitate the human immune system.

The first clinical trial will evaluate the safety and immunogenicity of the compounds designed to target Panton-Valentine Leukocidin and alpha toxin. The second will evaluate the safety and immunogenicity of the other three components of the vaccine. The third trial will evaluate the safety and immunogenicity of all five components.

"S. aureus infections adversely impact many active duty members and several phases of military operations, in addition to the well-being of U.S. citizens," said Dr. David Tribble, director of general infectious disease research at IDCRP. "We believe that investigating vaccine-based strategies is critical to prevent these common and serious infections both in military and civilian settings."


'/>"/>

Contact: JoAnn Sperber
jsperber@hjf.org
301-294-1234
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Related medicine news :

1. Dana Corporation, Inc. Enters Into Settlement Agreement With Dana Retiree Committee
2. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
3. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
4. Navitas Opens New Cancer Rehabilitation Center in Albuquerque in Conjunction With New Mexico Cancer Centers
5. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
6. Service-to-Sales Transformation at Contact Centers Hinges on Soft Skills
7. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
8. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
9. Commercial Insurers Reimbursement Rate to New Yorks Community Health Centers Jeopardizes Care
10. Pennsylvania Trauma Systems Foundation Accreditation Status for Trauma Centers
11. Vangent, Inc. Wins Spot on Centers for Medicare & Medicaid Services Enterprise System Development Contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... (PRWEB) , ... February 18, 2017 , ... ... presets. Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 for ... so many other applications. Users can pick and choose from hand-crafted trend-setting ...
(Date:2/17/2017)... ... 17, 2017 , ... Wells Pharmacy Network offers physicians WellsPx3, ... and non-controlled substances plus the ability to manage orders on their desktop or ... accept electronic prescriptions, according to the Office of the National Coordinator of Health ...
(Date:2/17/2017)... ... 2017 , ... Qualis Health, one of the nation's leading ... DecisionHealth Platinum Awards in recognition of its innovative healthcare management programs that are ... award categories, highlighting four of the organization’s current programs:, , ...
(Date:2/17/2017)... ... 17, 2017 , ... PrideStaff, a national staffing organization, is ... Staffing Industry Analysts' 2017 "Staffing 100 North America" list. , Now in ... to the staffing industry over the last twelve months. Industry insiders and observers ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... planning assistance to families and business owners in the greater Fort Lauderdale metropolitan ... organization. , For more than 30 years, LifeNet 4 Families has provided ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... Research and Markets has announced the ... Technologies" report to their offering. ... Traditional medical devices include ... non-drug coated implantables, large endoscopes, needle based drug delivery, lab ... last two to three decades for the treatment and management ...
(Date:2/16/2017)... 2017 DaVita Inc. (NYSE: DVA ) ... 31, 2016. Net income attributable to DaVita ... was $158 million, or $0.80 per share and $880 million, ... income attributable to DaVita Inc. for the quarter and year ... was $192 million, or $0.98 per share, and $789 million, ...
(Date:2/16/2017)... , Feb. 16, 2017  Aralez Pharmaceuticals Inc. ... specialty pharmaceutical company, today announced that executive management will ... to be held February 22-23, 2017. Adrian Adams ... the Company at 1:35 p.m. local time on Wednesday, ... audio archive for the event may be accessed from ...
Breaking Medicine Technology: