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HIV suppression not as good as previously thought, largest study of viral-load blood tests show
Date:7/22/2012

, and those already on ART are at risk of developing drug resistance, too." Gebo is an associate professor at the Johns Hopkins University School of Medicine and the University's Bloomberg School of Public Health.

As part of the decade-long study, more than 100,000 individual blood test results were reviewed, all obtained with permission from the medical records of 32,483 infected adults. Seventy percent were men. Everyone prescribed ART had their blood viral levels carefully monitored at more than a dozen established HIV clinics, including the Moore Clinic at The Johns Hopkins Hospital.

Among the study's specific findings was that the percentage of participants who tightly controlled their HIV disease was 72 percent in 2010, the last year for which viral load counts were analyzed. This represented a major increase from 45 percent in 2001, but was significantly less than the 77 percent to 87 percent figures widely cited in 2011 reports from the U.S. Centers for Disease Control and Prevention, and in studies by other leading Hopkins and Canadian researchers.

According to study lead investigator Baligh Yehia, M.D., M.S.H.P., M.P.P., a postdoctoral fellow at the University of Pennsylvania School of Medicine in Philadelphia who trained as a medical resident at Johns Hopkins, all previous reports were based on single-year or one-time-only recordings of blood viral levels, rather than a review of every patient's individual test results from year to year. The latter, he says, is a "more accurate" depiction of people's response to ART over the long term.

Other key findings in the latest report were that younger people, ages 18 to 29; blacks; injection drug users; and those without private health insurance were almost twice as likely as older people; whites; men who have sex with men; and those with private insurance to not have fully suppressed blood viral levels.

"Our data shows that while tremendous strides have been mad
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Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

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