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HIV research included in journal
Date:3/16/2011

ne globulins, for example, vary by approximately 100-fold based on the site and method of collection within the human female genital tract," explained Dr. Anderson, who is also assistant professor of obstetrics and gynecology at The Warren Alpert Medical School of Brown University. "More efforts are needed to standardize both sampling methods and assays of female genital tract immunity."

"Research attention has shifted from management of HIV to a focus on the most common site of acquisition the female genital tract," she explained. "If researchers do not consider specific clinical parameters when enrolling subjects into their studies, it could lead to faulty interpretation of results."

Important topics for researchers to consider, the article notes, are the method and source of sample collection, the individual patient characteristics, and, when recruiting HIV-infected women, HIV disease characteristics.

There are a number of clinical characteristics that are known to alter genital immunity, Dr. Anderson said. These include a woman's menstrual cycle, age, race, body mass index, any contraception being used, and recent intercourse.

"Contraception containing progesterone, for example, alter the cervical mucous and the uterine lining. Given that sex hormones alter many components of genital immunity, it is likely that hormonal contraception has some impact on the innate immunity within the female genital tract," she said. "This should be considered when conducting research."


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Contact: Susan McDonald
slmcdonald@wihri.org
401-681-2816
Women & Infants Hospital
Source:Eurekalert

Page: 1 2

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