Navigation Links
HIV research included in journal

A research article co-authored by Brenna Anderson, MD, director of Reproductive Infectious Diseases Consultation in the Division of Maternal-Fetal Medicine at Women & Infants Hospital of Rhode Island, was included in the recently published special issue of the American Journal of Reproductive Immunology.

The publication is an outgrowth of a workshop on the human immunodeficiency virus (HIV) that took place at Dartmouth Medical School in the summer of 2010. The workshop, sponsored by the National Institutes of Health and National Institute of Allergy and Infectious Diseases for invited attendees only, was designed to bring together HIV researchers who specialize in mucosal immunity. Mucosal immunity is one of the body's way of protecting itself against disease and is the next frontier for HIV researchers.

Dr. Anderson's article - co-written with Susan Cu-Uvin, MD, of The Miriam Hospital is entitled "Clinical Parameters Essential to Methodology and Interpretation of Mucosal Responses." It explores the clinical characteristics that are important for researchers to consider when they study the female genital tract in the quest for cures for HIV.

With more than 30 million people diagnosed with HIV across the world, millions of dollars continue to be spent on research aimed at fighting the disease. While the advent of antiretroviral therapy to treat HIV has not slowed the spread of infection, research has helped health care providers understand the disease, which has changed the life expectancy of an individual diagnosed with HIV in the United States from terminal to chronic illness.

Over the past few years, research attention has shifted from blood to the genital tract as the major point-of-entry for the virus. To effectively produce results, however, the proper guidelines must be established for research into the genital tract's mucosal immunity, Dr. Anderson noted.

"The normal values for the measurement of immune globulins, for example, vary by approximately 100-fold based on the site and method of collection within the human female genital tract," explained Dr. Anderson, who is also assistant professor of obstetrics and gynecology at The Warren Alpert Medical School of Brown University. "More efforts are needed to standardize both sampling methods and assays of female genital tract immunity."

"Research attention has shifted from management of HIV to a focus on the most common site of acquisition the female genital tract," she explained. "If researchers do not consider specific clinical parameters when enrolling subjects into their studies, it could lead to faulty interpretation of results."

Important topics for researchers to consider, the article notes, are the method and source of sample collection, the individual patient characteristics, and, when recruiting HIV-infected women, HIV disease characteristics.

There are a number of clinical characteristics that are known to alter genital immunity, Dr. Anderson said. These include a woman's menstrual cycle, age, race, body mass index, any contraception being used, and recent intercourse.

"Contraception containing progesterone, for example, alter the cervical mucous and the uterine lining. Given that sex hormones alter many components of genital immunity, it is likely that hormonal contraception has some impact on the innate immunity within the female genital tract," she said. "This should be considered when conducting research."


Contact: Susan McDonald
Women & Infants Hospital

Related medicine news :

1. Fragile X researcher honored by March of Dimes
2. Chasing the pot of gold: WSU researchers study gambling subtypes and treatment outcomes
3. Research shows rapid adoption of newer, more expensive prostate cancer treatments
4. DU researchers find that headway being made fighting communicable diseases globally
5. Research may lead to new and improved vaccines
6. UCIs Dr. Bang H. Hoang, colleagues recognized for bone cancer research
7. Mount Sinai researcher finds unexpected temperature sensation for a light detector
8. InDevR awarded $3 million grant from NIH for influenza-related research
9. Research suggests HIV-infected patients at higher risk for bone fractures
10. CWRU researcher sends message to postmenopausal women: Increase yearly dental checkups
11. Sones Innovation Award honors breast cancer vaccine research
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... The McHenry County law firm of ... obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. Attorneys Botto and Wimmer ... 2015 IL App (2d) 130884WC. , According to court documents, Adcock testified that on ...
(Date:11/25/2015)... ... November 25, 2015 , ... SCOTTSDALE, ... facial plastic surgeon specializing in both surgical and non-surgical treatments, announced the expansion ... at Hobgood Facial Plastic Surgery. , Highly trained and nationally recognized for ...
(Date:11/25/2015)... MI (PRWEB) , ... November 25, 2015 , ... In ... Presence Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy ... medical and surgical intensive care units (totaling 30 beds) from May 2014 through October ...
(Date:11/25/2015)... ... November 25, 2015 , ... Castlewood Treatment Center ... with eating disorders as a result of the $20,000 raised at the center’s ... Fox Run Golf Club in Eureka, will help individuals who otherwise might not ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately owned Contract Development ... expansion of its current state of the art research, development and manufacturing facility ... increase its manufacturing capacity as well as to support its clients’ growing research ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 ... the addition of the "2016 Future Horizons ... Monitoring (TDM) Market: Supplier Shares, Country Segment Forecasts, ... offering. --> ... comprehensive analysis of the Italian therapeutic drug monitoring ...
(Date:11/25/2015)... OAKS, Calif. , Nov. 25, 2015  Amgen ... a Biologics License Application (BLA) with the ... (FDA) for ABP 501, a biosimilar candidate to Humira ... first adalimumab biosimilar application submitted to the FDA and ... pathway. Sean E. Harper , M.D., executive ...
Breaking Medicine Technology: