Navigation Links
HIV persists in the gut despite long-term HIV therapy
Date:2/13/2008

Even with effective anti-HIV therapies, doctors still have not been able to eradicate the virus from infected individuals who are receiving such treatments, largely because of the persistence of HIV in hideouts known as viral reservoirs. One important reservoir is the gut, where HIV causes much of its damage due to the large number of HIV target cells that reside there. These cells, known as CD4+ T cells, are largely contained in lymph nodes and patches of lymphocytes that collectively are called gut-associated lymphoid tissue, or GALT.

Because of the importance of the gut to HIV disease, scientists hoped that long-term treatment with antiretroviral drugs could eradicate HIV from the GALT. A new NIAID study, published online by The Journal of Infectious Diseases, has found that this goal seems unlikely with current antiretroviral drugs.

Tae-Wook Chun, Ph.D., of the NIAID Laboratory of Immunoregulation (LIR), Anthony S. Fauci, M.D., LIR chief and NIAID director, and their colleagues intensively studied eight patients receiving effective antiretroviral therapy for up to 9.9 years. In each of these of these individuals, therapy had consistently kept their blood levels of HIV at undetectable levels. Sensitive tests, however, detected the persistence of HIV as well as lowered CD4+ T cell levels in the GALT that did not completely rebound in response to therapy. Levels of virus were higher in the GALT than in immune cells in the blood, where HIV also was consistently found. In addition, the scientists found evidence of cross infection between the GALT and the lymphocytes in the blood, suggesting that one reason the virus persists in the blood is because of ongoing cycles of replication in the GALT. The authors conclude that any possibility of further lowering or eliminating viral reservoirs likely will require more powerful drug regimens to stop the low levels of ongoing viral replication originating in the GALT. The development of such regimens i
'/>"/>

Contact: Laura Sivitz
sivitzl@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chronic infection persists by targeting stromal cell network in lymphoid organs
2. Despite Oncologists Willingness to Prescribe Avastin for Treatment of Breast Cancer, the FDA is Likely to Rule Against the Product on February 23
3. Despite polarized opinions, Democrats and Republicans perform same amount of green actions
4. Physicians Still Hopeful About Desmoteplase for the Treatment of Acute Ischemic Stroke Despite Negative Results
5. Herons persist in Chicago wetlands despite exposure to banned chemicals
6. Despite efforts, significant racial disparities in cancer therapy still exist
7. Coshocton County Memorial Hospital RNs to Strike Despite Hospitals Claim of Financial Hardship
8. Miscarriage myths persist despite prevalence of medical information
9. Research finds allergic children exposed to peanuts at younger ages despite recommendations to avoid
10. Enrollment Growth Slows at U.S. Nursing Colleges and Universities in 2007 Despite Calls for More Registered Nurses
11. A Full and Long Life, Despite Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Tenn. (PRWEB) , ... July 31, 2015 , ... The ... Robert Church Park in Downtown Memphis on October 3, 2015. The Ride to Fight ... focused on cancer research between Methodist Healthcare, The West Clinic and The University of ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy ... comes time to cook the next meal, making July the most appropriate to be ... grilling tips and recipes. , Make the next cookout different than the ones in ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... Rally Insurance Group, Inc. has re-branded their social media profiles to better connect ... way for consumers to communicate, find information, share insights and opinions. The Rally ...
(Date:7/31/2015)... ... July 31, 2015 , ... M3 USA MDLinx.com, source ... launch three new Board Exam Courses. , The additions of Gastroenterology, Pulmonology and ... Prep from MDLinx makes preparing for the exam easy and painless. MDLinx offers ...
(Date:7/31/2015)... CA (PRWEB) , ... July 31, 2015 , ... According to the article ... floor of the Pasadena courthouse was contained and extinguished by the city’s fire department before ... in the building at the time of the fire, and it was a fire alarm ...
Breaking Medicine News(10 mins):Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... to reach 8.3 million by the year 2030, with ... more is done to tighten trans-border controls on the ... two epidemics that are encountering a major increase in ... the HIV/AIDS epidemics," said Douglas Bettcher, director of the ...
... that POM Wonderful 100 pct Pomegranate Juice has beneficial ... the blood flow to the penis during sexual stimulation. ... examined the efficacy of pomegranate juice versus placebo in ... ,Mild ED is defined as the mildly decreased ability ...
... Dram, Scotland's national drink, is on sale for 1,000 pounds a ... in Perthshire, the rare Johnnie Walker 1805 has just gone on ... 200 bottles have been made to celebrate the birthday of the ... the makers claim, by the fact the majority of the nine ...
... US vice president and presently a high profile environmentalist, will ... ,He is behind the Live Earth program - ... various artists planned to take place on Saturday July 7, ... , The concerts have the intent of bringing ...
... District after over 100 people reportedly tested HIV positive. ... out of their village to nearby cities in search of ... ,The remote village fraught with poverty, illiteracy, unemployment and ... were reported in the last four years. , ...
... effective alternative treatment for sufferers of crippling rheumatoid arthritis, ... and Denmark. ,Severely affected patients already being ... capsules of rosehip powder for six months, a pilot ... more extensive trials, which could form the basis of ...
Cached Medicine News:Health News:Annual Tobacco-related Deaths to Reach 8.3 Million by 2030 2Health News:Pure Pomegranate Juice Helps Reverse Erectile Dysfunction Function 2Health News:Scot's National Drink, Now Available at 1,000 Pounds a Nip 2Health News:Live Earth Will Make the World More Aware of the Crisis Facing the Earth, Hopes Al Gore 2Health News:Live Earth Will Make the World More Aware of the Crisis Facing the Earth, Hopes Al Gore 3Health News:Jharkhand Village Shocked to Know About Its Huge HIV Positive Population 2Health News:Rosehips may Be an Effective Alternative for Rheumatoid Arthritis 2
(Date:7/31/2015)... MOUNT PROSPECT, Ill. , July 31, 2015 ... of Pharmacy ® (NABP ® ) issued ... charged with ensuring that action is taken against ... the Internet Drug Outlet Identification Program ... 2015 , thousands of websites ...
(Date:7/31/2015)... Fla. , July 31, 2015  Xcelience, ... today that it has made a structured cash ... -based company specializing in milling, micronization and powder ... will help grow Powdersize,s business while simultaneously adding ... to Xcelience,s portfolio of capabilities. ...
(Date:7/31/2015)... -- Xencor, Inc. (NASDAQ: XNCR ), a clinical-stage biopharmaceutical ... autoimmune diseases, asthma and allergic diseases, and cancer, today ... to its board of directors. "Yujiro,s ... a tremendous asset to our board," said Bassil ... Xencor. "Xencor faces a range of opportunities for our ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
... Oct. 21 Flextronics (Nasdaq: FLEX ) is ... agreement to acquire Slomedical S.R.O through a share purchase ... medical devices ranging from tubing sets to complex devices ... before the end of the calendar year, pending required ...
... Oct. 21 More than 25 Eli Lilly and Company ... celebrate "Energy Day," which is a new corporate sustainability effort ... reduction goals and to encourage sustainable behaviors. , ... early. Over a five-year period, from 2004 to 2008, Lilly ...
Cached Medicine Technology:Flextronics Announces Expansion of Medical Disposables Offering 2Lilly Surpasses Energy Efficiency Goals and Celebrates Worldwide Energy Day 2
... imaging agent that is labeled with technetium ... and localization of regions of reversible myocardial ... infarction under exercise and rest conditions. Imaging ... or up to 4 hours after administration ...
Universal Hub with Varying Blade Edge Diameters For Mounting the Blade to the Handle; Stainless Steel....
... Chloride Tl 201 Injection is supplied in ... diagnostic radiopharmaceutical for intravenous administration. Each milliliter ... Tl 201 at calibration time, made isotonic ... with 0.9% (v/v) benzyl alcohol. The pH ...
Elongated Loop, Slightly Curved; in Stainless Steel....
Medicine Products: