Navigation Links
HIV drug resistance risk in mothers reduced by combination of common drugs
Date:11/9/2007

BIRMINGHAM, Ala. -- New research from the University of Alabama at Birmingham (UAB) shows that adding a single dose of two common anti-HIV drugs can prevent HIV-positive pregnant women from developing resistance to an entire class of drugs, potentially improving future treatment options.

Providing tenofovir and emtricitabine with nevirapine during labor greatly reduces the extent of resistance to non-nucleoside reverse transcriptate inhibitors (NNRTIs), such as nevirapine, which HIV-positive women take to lower the risk of mother-to-child transmission during childbirth.

Benjamin Chi, M.D., assistant professor of obstetrics and gynecology at UAB, and colleagues, reported their findings online in this weeks edition of The Lancet. Chi said the drug combination reduced resistance to NNRTIs by more than half at six weeks after delivery. This finding is important because between 20 and 69 percent of women given nevirapine develop resistance to the NNRTIs after taking a single dose. Although resistance becomes undetectable one to two years after ingestion, there are concerns that it could still compromise a womans future treatment options.

In this study, 399 participants were randomly assigned to receive or not receive single dose tenofovir and emtricitabine along with routine care. Routine care meant starting the anti-HIV drug zidovudine (or AZT) at 32 weeks gestation, and then ingesting a single dose of nevirapine at the start of labor. Participants were healthy and did not yet require treatment with potent antiretroviral therapy. The main goal of the study was to see if there was a difference in the presence of NNRTI resistance mutations six weeks after giving birth. The study was conducted in Lusaka, Zambia between 2005 and 2007.

Overall, 12 percent of women given the tenofovir and emtricitabine dose developed NNRTI resistance, compared to 25 percent among those who did not receive the additional drugs. Tenofovir and emtricitabine appeared to be sa
'/>"/>

Contact: Jennifer Lollar
jpark@uab.edu
205-934-3888
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fat on chest and upper back increases risk of insulin resistance
2. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
3. Cell skeleton may hold key to overcoming drug resistance in cancer
4. Genetic approach provides new insight into trastuzumab resistance in breast cancer
5. Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies
6. FDA Warns of Codeine Risk for Some Nursing Mothers
7. Mothers Know Best: NFL Moms Team With Eddie George to Showcase a Better Way to a Healthier Lifestyle
8. Hip size of mothers linked to breast cancer in daughters
9. Overweight mothers run greater risk of having hyperactive children
10. New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction
11. Giving emergency nurses aromatherapy massages with music dramatically reduced stress levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... -- Your brain structure could help predict how willing you ... Researchers at Yale University found those with greater volume in ... may be more likely to engage in risky behavior than ... study, funded by the U.S. National Institute on Aging, involved ... the Northeast. The researchers sought to determine how brain structure ...
(Date:9/19/2014)... The Alliance for Bangladesh Worker Safety ... Fire Protection Association (NFPA), a recognized international leader ... a Memorandum of Understanding signed by both organizations, ... stakeholders with information, guidance and access to training ... safety of workers in ready-made garment (RMG) factories ...
(Date:9/19/2014)... 2014 In partnership with Raw Beauty NYC, ... part of the project’s social media efforts. StudioPMG is honored ... re-define the perception of beauty as it applies to disabled ... idea by Shelly Baer and Vanessa Silberman, who wanted to ... and beautiful. Ginny Dixon, Wendy Crawford, Susan Solman and Sabrina ...
(Date:9/19/2014)... Famous Vancouver company, Pro Ace Heating and Mechanical ... a one-stop-solution for heating, air conditioning, plumbing and electrical ... has achieved this status by providing a complete package ... are many companies that provide these services separately, it ... can offer all of these services together to clients. ...
(Date:9/19/2014)... Shahram Majidi, M.D., a second-year resident in ... University School of Medicine and Health Sciences, received ... to study the presence of diffuse brain swelling ... , "According to epidemiological studies, intracerebral hemorrhage accounts ... but is the least treatable form of stroke, ...
Breaking Medicine News(10 mins):Health News:Brain Structure Might Help Predict Risky Behavior 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:Pro Ace Now Provides Heating, Air Conditioning, Plumbing & Electrical Services under One Roof 2Health News:GW researcher receives grant to study brain swelling following bleeding in the brain 2
... devouring billions of dollars globally, Alzheimer,s disease is the ... Although intensely investigated over the last three decades using ... not been found. While many research "breakthroughs" have ... does the promised "cure" still seem to elude scientists? ...
... (HealthDay News) -- Good news for high-mileage runners: They may be ... because variations in diet are less likely to affect them, researcher ... grouped according to the distance they run each day: less than ... to 4 km); 2.4 to 3.7 miles (4 to 6 km); ...
... published research shows that more patients with end-stage ... hemodialysis as their initial kidney replacement therapy over ... the study now available in Arthritis Care ... College of Rheumatology (ACR), also found that African ...
... device that combines two microimaging technologies can reveal ... biological activities that, in coronary arteries, could indicate ... of clots in arterial stents. In their ... Massachusetts General Hospital (MGH) investigators describe using an ...
... Special Surgery physician-scientists who focus on arthritis, lupus, vasculitis ... to Chicago this week to share their recent findings ... College of Rheumatology (ACR). Special Surgery investigators will ... care. Of the meeting,s highlights, results from the nine-year ...
... appear to be stopping anti-TNF medications before surgery, but may ... a new study by researchers at Hospital for Special Surgery. ... diseases, including rheumatoid arthritis, and better timing of withdrawal prior ... "We need to do more studies to see ...
Cached Medicine News:Health News:New study challenges accepted approaches to research in senile dementia (Alzheimer's disease) 2Health News:New study challenges accepted approaches to research in senile dementia (Alzheimer's disease) 3Health News:Runners Can Relax About Holiday Feasting: Study 2Health News:Most lupus nephritis patients with end-stage renal disease opt for hemodialysis therapy 2Health News:Combined arterial imaging technology reveals both structural and metabolic details 2Health News:Hospital for special surgery physician-scientists share advances in rheumatology research 2Health News:Hospital for special surgery physician-scientists share advances in rheumatology research 3Health News:Hospital for special surgery physician-scientists share advances in rheumatology research 4Health News:Hospital for special surgery physician-scientists share advances in rheumatology research 5Health News:Hospital for special surgery physician-scientists share advances in rheumatology research 6Health News:Tweaking withdrawal of rheumatoid arthritis medications before surgeries may reduce disease flares 2Health News:Tweaking withdrawal of rheumatoid arthritis medications before surgeries may reduce disease flares 3
(Date:9/19/2014)... Sept. 19, 2014 Kiromic, LLC, a ... Kent Hance , the former chancellor of Texas Tech ... as chancellor in July 2014, after raising $1.2 billion for ... Kent Hance , the most successful chancellor in the ... not only as an investor, but also as our new ...
(Date:9/19/2014)... , September 19, 2014 ... by Equipment (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture Mirror, ... (Hospitals), Advanced technologies - Global Forecast to 2019" ... poised to reach $19,786.3 Million by 2019 from ... 6.8% from 2014 to 2019. Browse ...
(Date:9/19/2014)... , Sept. 19, 2014  4WEB Medical announces the ... foot and ankle osteotomy implants on the market ... Society annual meeting in Chicago . ... of a surgeon,s osteotomy needs with 74 size options included ... had smaller offerings of only 15 to 18 implant sizes, ...
Breaking Medicine Technology:Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 44WEB Medical Unveils 3D-Printed Osteotomy Truss System 2
... (NASDAQ: THOR ), a world leader in ... restore failing hearts, said today revenues for the second ... increase over revenues of $95.1 million in the second ... of fiscal 2010 exclude contributions from the company,s International ...
... Inc. (NASDAQ: CADX ), a biopharmaceutical company ... for use in the hospital setting, today reported financial ... 30, 2011. Cadence commercially launched OFIRMEV® (acetaminophen) ... to be approved in the U.S., in January 2011. ...
Cached Medicine Technology:Thoratec Reports Second Quarter Revenue Increase of 17 Percent 2Thoratec Reports Second Quarter Revenue Increase of 17 Percent 3Thoratec Reports Second Quarter Revenue Increase of 17 Percent 4Thoratec Reports Second Quarter Revenue Increase of 17 Percent 5Thoratec Reports Second Quarter Revenue Increase of 17 Percent 6Thoratec Reports Second Quarter Revenue Increase of 17 Percent 7Thoratec Reports Second Quarter Revenue Increase of 17 Percent 8Thoratec Reports Second Quarter Revenue Increase of 17 Percent 9Thoratec Reports Second Quarter Revenue Increase of 17 Percent 10Thoratec Reports Second Quarter Revenue Increase of 17 Percent 11Thoratec Reports Second Quarter Revenue Increase of 17 Percent 12Thoratec Reports Second Quarter Revenue Increase of 17 Percent 13Thoratec Reports Second Quarter Revenue Increase of 17 Percent 14Thoratec Reports Second Quarter Revenue Increase of 17 Percent 15Thoratec Reports Second Quarter Revenue Increase of 17 Percent 16Thoratec Reports Second Quarter Revenue Increase of 17 Percent 17Thoratec Reports Second Quarter Revenue Increase of 17 Percent 18Thoratec Reports Second Quarter Revenue Increase of 17 Percent 19Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 2Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 3Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 4Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 5Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 6Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 7Cadence Pharmaceuticals Reports Second Quarter 2011 Financial Results 8
... Trinity Biotech Captia™ Varicella-Zoster Virus (VZV) IgG ... the detection and quantitative determination of IgG ... serum specimens may be used for the ... and convalescent, may be used to demonstrate ...
Varicella-zoster virus (VZV) IgM Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection of IgM antibody to Varicella-zoster virus in human serum as an aid in the diagnosis of primar...
The DSL-05-10-VZM Varicella Zoster IgM Enzyme-Linked Immunosorbent Assay (ELISA) kit provides materials for the determination of IgM-class antibodies to Varicella Zoster Virus in human serum. This as...
... Mumps IgM Enzyme-Linked Immunosorbent Assay ... qualitative detection of IgM antibody ... for the determination of immunological ... this kit have not been ...
Medicine Products: