Navigation Links
HIV Vaccine Failure Still Brings Insights

Researchers say lessons learned might one day lead to vaccine that works

THURSDAY, Nov. 13 (HealthDay News) -- The latest attempt to develop an AIDS vaccine has failed, but researchers report that they've still gained insight into how to make the next one more effective.

"It's raised a whole new set of questions that are going to be really important to answer to get us to a successful vaccine," said Dr. Susan P. Buchbinder, lead author of a study published online Nov. 13 in The Lancet. "We couldn't have raised them or even anticipated them before doing this study."

Among other things, researchers now know that they need to understand the role of the foreskin in HIV transmission because uncircumcised men who were vaccinated had a higher rate of infection, said Buchbinder, director of the HIV research section at the San Francisco Department of Public Health.

Scientists have long dreamed about creating a vaccine to prevent transmission of HIV, the virus that causes AIDS. But the disease has turned out to be extremely stubborn. Among other things, HIV's ability to mutate into new forms has made it difficult to develop a vaccine that can keep up with all the changes.

Two experimental HIV vaccines have made it to testing in large numbers of people, but both failed to work.

In their study, Buchbinder and her colleagues looked at the results of testing of the second vaccine, which was developed by Merck & Co. Some of the results have already been released.

Researchers enrolled 3,000 HIV-negative people from North America, South America, the Caribbean and Australia in the study. Some received doses of the vaccine while others got a placebo.

The researchers found that 4.6 percent of those who received the vaccine became infected with HIV, compared to 3.1 percent of those who didn't get the vaccine.

It wasn't clear if the difference was statistically significant, but researchers did find that uncircumcised men were at higher risk of getting infected.

This suggests that scientists need to better understand how the foreskin affects the immune system's response to HIV, Buchbinder said.

Infection rates were also higher among those who had developed immunity to a virus that causes colds. This is important because scientists got the HIV vaccine to enter the body by piggybacking on a weakened bit of the same type of cold virus.

The vaccine can't cause HIV, and the weakened cold virus can't cause a cold, Buchbinder said.

But, there's another possibility, she said. The increase in infection rates among the two groups -- uncircumcised men and those who had immunity to the cold virus -- could be purely due to chance. Or some other factors could be at play.

The failure of the Merck vaccine "profoundly affected the HIV-vaccine development field," Dr. Merlin L. Robb, of the U.S. Military HIV Research Program, wrote in a commentary accompanying the study.

"We have learned that future HIV vaccines will need to generate stronger, broader or different types of immune responses in order to be effective," he said in an interview.

More information

Learn more about HIV vaccine research from the U.S. Centers for Disease Control and Prevention.

SOURCES: Susan P. Buchbinder, M.D., director, HIV research section, San Francisco Department of Public Health; Merlin L. Robb, M.D., U.S. Military HIV Research Program, Rockville, Md.; Nov. 13, 2008, The Lancet, online

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Consumer Reports Survey: Nearly Half of Adults Wont Get Flu Vaccine, Citing Poor Excuses Like I Dont Get Sick
2. New Vaccines for Adults: Which do you Need? From Harvard Medical School
3. Research indicates need for effective HPV vaccine for women and men and a simple HPV screening test
4. Moores UCSD Cancer Center studying novel leukemia vaccine for high-risk patients
5. Therapeutic vaccines
6. Minor shift in vaccine schedule has potential to reduce infant illness, death
7. Pakistan introduces vaccine to prevent top child killer
8. Flu Vaccine Could Prevent 357,000 Deaths in Pandemic
9. Fight begins to eradicate fatal parasite; first vaccines delivered following major funding award
10. New intranasal influenza vaccine triggers robust immunity with significantly less antigen
11. When It Comes to Flu, the More Who Get Vaccine, the Better
Post Your Comments:
Related Image:
HIV Vaccine Failure Still Brings Insights
(Date:11/25/2015)... ... November 25, 2015 , ... The holiday ... dish and pleasing the palates of attendees is of the utmost importance. Whether ... a seasonal get-together, give these recipes a try this holiday season. , Turkey ...
(Date:11/25/2015)... Nairobi (PRWEB) , ... November 26, 2015 , ... ... African Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, ... Nations Office in Nairobi (UNON) for the opening of the 5th African Network ...
(Date:11/25/2015)... ... 25, 2015 , ... Dental professionals who would like to become more proficient ... attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be held ... the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are proud ...
(Date:11/25/2015)... ... 2015 , ... Smiles by Stevens is pleased to announce the ... While many patients are aware of the benefits of Botox® in the treatment of ... suffering with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I saw a ... “I thought there had to be a convenient and comfortable way to protect them ... enables disabled individuals to safely travel during cold or inclement weather. In doing so, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- ) has announced the ... Viscosity Drugs" report to their offering. ... of the "Self Administration of High Viscosity ... Research and Markets ( ) has ... of High Viscosity Drugs" report to their ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: AMGN ... Application (BLA) with the United States ... 501, a biosimilar candidate to Humira ® (adalimumab). ... application submitted to the FDA and represents Amgen,s first ... Sean E. Harper , M.D., executive vice president of ...
Breaking Medicine Technology: