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HIV Vaccine Failure Still Brings Insights
Date:11/13/2008

Researchers say lessons learned might one day lead to vaccine that works

THURSDAY, Nov. 13 (HealthDay News) -- The latest attempt to develop an AIDS vaccine has failed, but researchers report that they've still gained insight into how to make the next one more effective.

"It's raised a whole new set of questions that are going to be really important to answer to get us to a successful vaccine," said Dr. Susan P. Buchbinder, lead author of a study published online Nov. 13 in The Lancet. "We couldn't have raised them or even anticipated them before doing this study."

Among other things, researchers now know that they need to understand the role of the foreskin in HIV transmission because uncircumcised men who were vaccinated had a higher rate of infection, said Buchbinder, director of the HIV research section at the San Francisco Department of Public Health.

Scientists have long dreamed about creating a vaccine to prevent transmission of HIV, the virus that causes AIDS. But the disease has turned out to be extremely stubborn. Among other things, HIV's ability to mutate into new forms has made it difficult to develop a vaccine that can keep up with all the changes.

Two experimental HIV vaccines have made it to testing in large numbers of people, but both failed to work.

In their study, Buchbinder and her colleagues looked at the results of testing of the second vaccine, which was developed by Merck & Co. Some of the results have already been released.

Researchers enrolled 3,000 HIV-negative people from North America, South America, the Caribbean and Australia in the study. Some received doses of the vaccine while others got a placebo.

The researchers found that 4.6 percent of those who received the vaccine became infected with HIV, compared to 3.1 percent of those who didn't get the vaccine.

It wasn't clear if the difference was statistically significant,
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