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HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
Date:7/27/2012

nt paper, the Berlin Patient -- Timothy Ray Brown of Seattle -- also had been diagnosed with HIV and also underwent chemotherapy (for acute myeloid leukemia) and developed graft-versus-host disease.

But, unlike the current patients, Brown received his stem cell transplant from a donor who had a rare genetic mutation that increases immunity against the most common form of HIV. He remained HIV-free after discontinuing antiretroviral therapy.

The two men described here received donor cells, which were "fully susceptible" to HIV, Kuritzkes said. This raises the possibility that a cure may be possible even when the donor does not have this gene mutation, he said.

Because this research has not been peer-reviewed and published in a medical journal, the data and conclusions should be considered preliminary.

More information

Visit the U.S. Centers for Disease Control and Prevention for more on HIV/AIDS.

SOURCES: Daniel Kuritzkes, M.D., chief, infectious diseases, Brigham and Women's Hospital, and professor, medicine, Harvard Medical School, Boston; Savita Pahwa, M.D., professor of microbiology and immunology, and director, Center for AIDS Research, University of Miami Miller School of Medicine; study abstract, July 26, 2012, International AIDS Conference, Washington, D.C.


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