Navigation Links
HIV Hides Out in Bone Marrow Cells
Date:3/7/2010

Another secret stash of the virus makes it that much harder to eliminate, scientists say

SUNDAY, March 7 (HealthDay News) -- Medications can reduce the level of the AIDS virus in the blood to zero, but HIV doesn't disappear and often roars back when patients stop taking their pills. Now, research is giving scientists new insight into how the virus manages to hide and avoid the killing powers of medicine.

In a new study, researchers report that the virus lurks in certain bone marrow cells and "reawakens" only under certain circumstances.

The research provides a new target for scientists, but it also presents new challenges because killing off bone marrow cells is a dicey proposition.

Overall, the findings provide "a better understanding of how HIV hides in the body" and could lead to better strategies to kill or control it, said study co-author Dr. Kathleen Collins, an associate professor of internal medicine at the University of Michigan.

Doctors have long known about the ability of HIV -- the AIDS virus -- to avoid being killed off completely by medications. Drugs may prevent the virus from infecting new cells, "but they don't get rid of cells that contain the virus and have potential to make new viral particles," Collins said.

This helps explain why HIV isn't curable. The immune systems of patients may be able to control the virus for a time but later fall victim to a renewed attack and, ultimately, to AIDS.

"A patient cannot be cured of HIV until all sources of infection are eliminated," said Jerome A. Zack, director of the UCLA Center for AIDS Research in Los Angeles.

But where does the virus hide when it's not in the blood? Researchers have suspected that the bone marrow -- which creates blood cells -- could serve as the hiding place.

In the new study, published in the March 7 online edition of Nature Medicine, researchers examined bits of AIDS virus and cells from infected people in the laboratory.

The investigators found that the virus can infect certain kinds of bone marrow cells that are the parents ("progenitors") of blood cells, Collins said.

So why not use a medication to kill all those parent cells, thereby perhaps ridding the body of HIV?

It sounds simple, but killing all of these blood-producing marrow cells would be lethal to humans, Collins said. However, "maybe we could find ways of targeting only the latently infected bone marrow cells," she added.

Zack, the UCLA researcher, said the study findings are convincing, but "we as yet do not have easy ways to eliminate these dormant sources of virus. The challenge to the field is to find all sources of virus -- this study identifies one -- and identify ways to eliminate them. Only by developing strategies to eliminate all the different sources can we purge HIV from the body."

In the long run, study co-author Collins said, the findings could help scientists develop ways to eradicate HIV or turn lifelong medication therapy "into a therapy that might last for a defined period of time."

More information

There's more on treating HIV/AIDS at Avert.org.



SOURCES: Kathleen Collins, M.D., Ph.D., associate professor of internal medicine, University of Michigan, Ann Arbor; Jerome A. Zack, Ph.D., director, UCLA Center for AIDS Research, Los Angeles; March 7, 2010, Nature Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Governors Health Plan Hides the True Cost of a Mandatory Purchase Requirement, Testimony Shows
2. Super-Thin Drug-Free Coating Hides Stent as It Unblocks Heart Arteries
3. Scientists Uncover How HIV Hides Inside Cells
4. FRC Says Planned Parenthood, Desperate to Hide Agenda, Attacks Hatch and Hides Intent
5. StemCor Systems Receives FDA Clearance for Bone Marrow Harvesting System
6. Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program
7. Oral drug sets a new survival standard for bone marrow cancer
8. Bone marrow cell transplants help nerve regeneration
9. StemCor Systems Announces Acquisition of Intellectual Property to Enhance Bone Marrow Aspiration Platform
10. Transplanted Bone Marrow Cells Aid Nerve Regeneration
11. Stem cells make bone marrow cancer resistant to treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: