Navigation Links
HIV Drug Combo May Help Prevent Malaria Reinfection
Date:11/28/2012

WEDNESDAY, Nov. 28 (HealthDay News) -- Treatment with a combination of certain HIV drugs greatly reduces the risk of recurrent malaria in children with HIV who are also being treated with drugs to prevent the mosquito-borne infection, according to new research.

The study included more than 170 HIV-positive infants and children up to 6 years old in Uganda who were receiving anti-malarial drugs and HIV treatment, including either a combination of the protease inhibitors lopinavir and ritonavir, or a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Despite the anti-malarial drugs and other preventive measures -- such as mosquito nets -- the children's risk of developing malaria during their first six months of HIV treatment was more than 40 percent. The risk during that time period was about the same whether the children were taking the protease inhibitors or an NNRTI, the investigators found.

However, among children who developed malaria and were successfully treated for it, 41 percent of those taking an NNRTI had a recurrence of malaria within 28 days compared with 14 percent of those taking the protease inhibitors.

And after 63 days, malaria recurrence had occurred among 54 percent of those taking an NNRTI and 28 percent of those taking the protease inhibitors, the research showed.

Blood levels of anti-malarial drugs in children taking the protease inhibitors were higher than in those taking an NNRTI, the researchers said.

The study, published Nov. 29 in the New England Journal of Medicine, was funded by the U.S. National Institute of Child Health and Human Development.

"It's possible that these protease inhibitors prevent anti-malarial drugs from breaking down or have some other additive effect against the malarial parasite," Dr. Lynne Mofenson, chief of the Pediatric, Adolescent, and Maternal AIDS Branch at the NICHD, said in an institute news release.

"Laboratory studies also suggest that protease inhibitors can block the malaria parasite outright. Finding out why this drug combination is effective is an area for further study," she added.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about malaria.

-- Robert Preidt

SOURCE: U.S. National Institute of Child Health and Human Development, news release, Nov. 28, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Being neurotic, and conscientious, a good combo for health
2. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
3. Cooking-Oil Combo May Improve Blood Pressure
4. Double drug combo could shut down abnormal blood vessel growth that feeds disease
5. Drug combo better for common type of metastatic breast cancer, UCI-led study finds
6. Booze, Energy Drinks, Casual Sex Combo Common in College: Study
7. FDA Approves Combo Shot for Meningitis, Hib in Kids
8. Combo Therapy May Help Ease Ringing in the Ears
9. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
10. Two-Drug Combo May Be Safe for Melanoma Treatment
11. Two-Drug Combo Helps Teens With Migraines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
HIV Drug Combo May Help Prevent Malaria Reinfection
(Date:3/22/2017)... ... 2017 , ... Soriant recognizes that identifying savings opportunities can ... facilities across the country are always forced to focus on costs and budgets. ... country, an efficient and quick way to estimate savings potential within specific support ...
(Date:3/22/2017)... ... March 22, 2017 , ... In ... and print media enterprise focused on cancer patients, cancer centers and advocacy groups, ... special 12-part educational video series, “No Ifs, Ands, or Butts,” that focuses on ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... that its digital marketing solutions have enabled Children’s Hospital of The King’s Daughters ... , Recognizing the value of a digital marketing approach, the 206-bed pediatric ...
(Date:3/22/2017)... ... 2017 , ... An intensive search of the medical literature has revealed no ... PhD. He says investigating this possibility, is important because Miami-Dade in 2016 ... infections with HIV. , His findings appear on Analizir.com. . Dr. ...
(Date:3/22/2017)... ... March 22, 2017 , ... University Orthopedics (UOI) today ... Division of Hand, Upper Extremity and Microvascular Surgery at Newport Hospital. Dr. Bragdon ... both Orthopedics and Hand Surgery. , As the leader of comprehensive orthopedic ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... MarketNewsUpdates.com News Commentary  ... As ... oil continues to rise in popularity with consumers, Cannabis ... enhancing production through acquiring innovative assets and other plant ... include: Future Farm Technologies Inc (OTC: FFRMF) (CSE: FFT.CN), mCig, ...
(Date:3/22/2017)... 2017 Biosensors International Group, Ltd. ("Biosensors" or the ... the enrollment of the first American patient in LEADERS FREE II, its ... will include sites in the United States , ... Italy , and the United Kingdom . ... The BioFreedom drug-coated stent (DCS) ...
(Date:3/22/2017)... SAN DIEGO , March 22, 2017 /PRNewswire/ ... company, announced today that it has entered into ... direct placement of 1,312,000 shares of common stock ... aggregate gross proceeds of $3,148,800.  The offering is ... 2017, subject to satisfaction of customary closing conditions. ...
Breaking Medicine Technology: