Navigation Links
HIV Can Re-Emerge From a Single Cell
Date:10/20/2008

Findings show patients should take their medications as prescribed

MONDAY, Oct. 20 (HealthDay News) -- It's been a mystery for medical researchers: How does the AIDS virus bring itself back to life after powerful drugs allow infected people to eliminate all signs of the disease in their blood?

Now, new research suggests HIV can hibernate inside a small number of cells -- or even a single cell -- until re-emerging to wreak havoc.

Study co-author Huldrych Gunthard, a researcher at University Hospital Zurich, in Switzerland, said the findings are actually good news, because they suggest that the virus isn't replicating itself while dormant. That could mean that AIDS patients who adhere to their drug regimens as prescribed will avoid having to fight a newly strengthened virus.

"It is a very good message for patients and doctors," Gunthard said.

While drugs available since the mid-1990s have allowed many AIDS patients to reduce the level of the virus in their blood to zero, the disease remains incurable. According to Gunthard, the virus can hide in the lymphatic system -- which includes lymph nodes, the spleen and other organs -- and in the brain and bone marrow, among other places.

Doctors generally urge AIDS patients to take their medication on a regular basis, because the virus can make a dramatic -- and potentially deadly -- reappearance if there aren't drugs in the body to keep it at bay.

In the new study, Gunthard and colleagues examined the AIDS virus from 20 patients who had gone off their medications for two weeks at a time as part of a study. By examining how the virus evolved over time, the researchers found that the disease can emerge from a small number of cells, or even a single one, when medication is stopped.

"This is actually very surprising, if one considers that there are millions of cells in the body from which the infection can take off," Gunthard said.

The research, published in this week's Proceedings of the National Academy of Sciences, also suggests that the virus doesn't evolve into new forms while patients aren't taking AIDS drugs. Evolution of the virus can lead to new forms that aren't as susceptible to drugs.

"This is a very good finding and suggests that our treatments are really very potent, and the effects will be long lasting," Gunthard said.

Dr. Jeffrey Laurence, director of the Laboratory for AIDS Virus Research at Weill Medical College of Cornell University, said the new findings reflect the findings of other research.

"These studies imply that current anti-HIV drug regimens are about as potent as they can be, completely blocking viral replication, and thus cell-to-cell transmission of virus," he said. "Therefore, any virus measured in the blood of a patient on long-term therapy -- assuming they are adherent to their medications -- most likely comes only from cells infected prior to the start of HIV treatment."

More information

Learn more about HIV from the U.S. Centers for Disease Control and Prevention.



SOURCES: Huldrych Gunthard, researcher, University Hospital Zurich, Switzerland; Jeffrey Laurence, M.D., professor of medicine, and director, Laboratory for AIDS Virus Research, Weill Medical College of Cornell University, New York City; Oct. 20-24, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
2. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
3. Milestone Scientific Commences Declaratory Judgment Action With Respect to Its Single Tooth Anesthesia (STA(TM)) System and Compudent(TM) System
4. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
5. International Watchdog Group Singles Out Resurrection for Anti-Union Violations
6. Sentillion Introduces Affordable Next Generation Healthcare Single Sign-On Solution Called expreSSO(TM)
7. Married esophageal cancer patients fare worse in some quality of life aspects than single patients
8. Verathon Inc. Introduces GlideScope(R) Ranger Single Use Video Laryngoscope for Emergency Departments, EMS and Military; Enables Fast Intubations and Eliminates Time-Consuming Disinfection
9. National Nurses Movement Lauds Al Gore for Leadership on Single-Payer Healthcare
10. Methodist Health System Foundation Announces Largest Single Gift
11. Alexza and Autoliv Announce Commercial Manufacturing and Supply Agreement for Heat Packages Used in Single-Dose Staccato(R) System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... St. Louis, MO (PRWEB) , ... August 22, 2017 , ... ... and career fairs to help healthcare employers connect with physicians and advanced practitioners like ... of virtual career fairs in August through November of this year. The ...
(Date:8/21/2017)... Aliso Viejo, CA (PRWEB) , ... August 21, 2017 , ... ... Pixel Film Studios. Editors can quickly and easily add washed color grades to ... an image. The LUT changes every pixel’s color to the corresponding color indicated by ...
(Date:8/21/2017)... , ... August 21, 2017 , ... ... recognized community involvement program serving the people of Michigan. The new initiative fundraises ... 120 years at the very forefront of animal protection and welfare by addressing ...
(Date:8/21/2017)... ... 2017 , ... San Diego physician and surgeon Dr. James Veltmeyer, author of ... candidacy for the 52nd Congressional District currently held by Representative Scott Peters. , ... country at age eleven after suffering homelessness and hardship in a distant land, I ...
(Date:8/20/2017)... (PRWEB) , ... August 20, 2017 , ... ... the HIPAA ComplyPAK™ Compliance Management System has assisted multiple clients in ... Certified Public Accountants, Service Organization Control Level 2 (AICPA SOC Level 2), and ...
Breaking Medicine News(10 mins):
(Date:8/1/2017)... 1, 2017   CerSci Therapeutics , a non-opioid ... , has received notice from the National Institute ... Health (NIH) that it has been awarded a Direct-to-Phase ... $650,000 in 2017 with an additional $1,000,000 to follow ... Drug application of their lead non-opioid drug candidate CT-044 ...
(Date:7/28/2017)... Inc. ("Hill-Rom") (NYSE: HRC), today announced financial results for ... updated its financial outlook for fiscal 2017. ... quarter, Hill-Rom reported earnings of $0.09 per diluted share ... period. These results reflect after-tax special items, including a ... the non-cash write-down of assets associated with the planned ...
(Date:7/26/2017)... Colo. , July 26, 2017 E.I. ... Guttridge and the Bimini SharkLab to custom design the worlds ... images of sharks in their native habitat. In preparation ... Discovery Channel,s Shark Week, Dr. Guttridge approached EIMI ... take pregnancy diagnosis directly to hammerhead sharks underwater. ...
Breaking Medicine Technology: