Navigation Links
HIV Can Penetrate a Woman's Healthy Genital Skin

Study finds virus can reach immune cells in just 4 hours

TUESDAY, Dec. 16 (HealthDay News) -- A new route of male-to-female transmission of HIV -- in which the virus can travel through healthy genital skin to reach immune cells in just four hours -- has been identified by U.S. researchers.

It's long been believed that the normal lining of the vaginal tract was an effective barrier to HIV during sexual intercourse, because the large HIV virus couldn't penetrate the tissue. But the Northwestern University Feinberg School of Medicine researchers found that HIV can penetrate normal, healthy genital tissue to a depth where it can get to immune cells and infect them.

The researchers labeled HIV viruses with photo-activated fluorescent tags and were able to track the viruses as they penetrated the outermost lining of the female genital tract (the squamous epithelium) in female human tissue obtained through hysterectomy and in animal models.

The findings were expected to be presented Dec. 16 at the American Society for Cell Biology annual meeting, in San Francisco.

"This is an unexpected and important result. We have a new understanding of how HIV can invade the female genital tract," principal investigator Thomas Hope, a professor of cell and molecular biology, said in a university news release.

"Until now, science has really had no idea about the details of how sexual transmission of HIV actually works. The mechanism was all very murky," Hope said.

These findings, if confirmed in future studies, could help in the development of new microbicides and vaccines to protect women against HIV.

"We urgently need new prevention strategies or therapeutics to block the entry of HIV through a woman's genital skin," said Hope. While condoms are 100 percent effective in blocking HIV, "people don't always use them for cultural and other reasons."

Women account for 26 percent of all new HIV cases in the United States, according to the U.S. Centers for Disease Control and Prevention. Based on its most recent analysis of 2005 data, the CDC estimated that there were 56,300 new HIV infections that year, and 31 percent were due to high-risk heterosexual contact. More than half of the new cases of HIV infection worldwide are in women.

More information

The U.S. Food and Drug Administration has more about women and HIV.

-- Robert Preidt

Northwestern University, news release, Dec. 16, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Which segments of the gastrointestinal tract does Salmonella enteritidis penetrate?
2. Fibers in Semen Help HIV Penetrate Cells
3. Beth Israel Deaconess Medical Center Maintains Healthy IT Servers With Third Brigade
4. YMCA of the USA Expands Healthy Communities Initiatives With $6.8 Million Grant from the Robert Wood Johnson Foundation
5. Womens Health The Daily Fix Your Guide to Healthy Habits for Good Nutrition
6. Average Americans Without Health Insurance Are Young and Healthy With Above Average Incomes
7. A Healthy New Year's Resolution for Your Eyes
8. Provides Parents With Sense of Relief
9. Healthy Eating and Good Nutrition Go Hand-in-Hand in Tight Economic Times
10. Healthy Travel Media Launches Second Edition of Patients Beyond Borders Singapore Edition
11. Nets Provide Fans with Healthy In-Game Snack Option
Post Your Comments:
(Date:12/1/2015)... York, NY (PRWEB) , ... December 01, 2015 ... ... epidemic in the 1980s we have seen vast improvements in scientific research and ... made significant strides, providing increased hope and relief to those affected by HIV/AIDS. ...
(Date:12/1/2015)... ... December 01, 2015 , ... The workstation boundaries for imaging ... Information Systems launches MED-TAB™ -- the world’s first portable DICOM-calibrated medical image display, ... to December 4, 2015. , MED-TAB is expected to change teleradiology because ...
(Date:12/1/2015)... ... December 01, 2015 , ... For many X-rays taken at ... accurate interpretation by the radiologist. The marking utensils are so small, however, they ... found a way to alleviate this problem. , He developed the patent-pending MARK ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... of Excellence (BHCOE) today announced that the organization has awarded Education and Developmental ... with a Distinguished Award. The award celebrates exceptional special needs providers that excel ...
(Date:12/1/2015)... ... 2015 , ... Lutronic, a leading innovator of aesthetic and medical laser and ... for sale in the United States. Clarity is a Superior Dual Wavelength Platform ... into a single platform that is easy to own and operate. , For ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015 ... today announced that its Chief Executive Officer, ... the Oppenheimer Annual Healthcare Conference in New ... in the conference through a webcast on ... , --> ...
(Date:12/1/2015)... India and PITTSBURGH , ... today announced that it expects to be the first ... markets funded by international donors, TLE400 (Tenofovir Disoproxyl Fumarate ... mg) for $99 per patient, per year. Mylan partnered ... TLE400. The significantly reduced price could generate savings of ...
(Date:12/1/2015)... Breg, Inc ., a premier provider ... it has been awarded three contracts by Novation, a ... will have access to improved pricing for Breg,s portfolio ... goods dedicated to advancing orthopedic care.  ... population, rising prevalence of chronic conditions and the health ...
Breaking Medicine Technology: