Navigation Links
HIV Can Penetrate a Woman's Healthy Genital Skin
Date:12/16/2008

Study finds virus can reach immune cells in just 4 hours

TUESDAY, Dec. 16 (HealthDay News) -- A new route of male-to-female transmission of HIV -- in which the virus can travel through healthy genital skin to reach immune cells in just four hours -- has been identified by U.S. researchers.

It's long been believed that the normal lining of the vaginal tract was an effective barrier to HIV during sexual intercourse, because the large HIV virus couldn't penetrate the tissue. But the Northwestern University Feinberg School of Medicine researchers found that HIV can penetrate normal, healthy genital tissue to a depth where it can get to immune cells and infect them.

The researchers labeled HIV viruses with photo-activated fluorescent tags and were able to track the viruses as they penetrated the outermost lining of the female genital tract (the squamous epithelium) in female human tissue obtained through hysterectomy and in animal models.

The findings were expected to be presented Dec. 16 at the American Society for Cell Biology annual meeting, in San Francisco.

"This is an unexpected and important result. We have a new understanding of how HIV can invade the female genital tract," principal investigator Thomas Hope, a professor of cell and molecular biology, said in a university news release.

"Until now, science has really had no idea about the details of how sexual transmission of HIV actually works. The mechanism was all very murky," Hope said.

These findings, if confirmed in future studies, could help in the development of new microbicides and vaccines to protect women against HIV.

"We urgently need new prevention strategies or therapeutics to block the entry of HIV through a woman's genital skin," said Hope. While condoms are 100 percent effective in blocking HIV, "people don't always use them for cultural and other reasons."

Women account for 26 percent of all new HIV cases in the United States, according to the U.S. Centers for Disease Control and Prevention. Based on its most recent analysis of 2005 data, the CDC estimated that there were 56,300 new HIV infections that year, and 31 percent were due to high-risk heterosexual contact. More than half of the new cases of HIV infection worldwide are in women.

More information

The U.S. Food and Drug Administration has more about women and HIV.



-- Robert Preidt



Northwestern University, news release, Dec. 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Which segments of the gastrointestinal tract does Salmonella enteritidis penetrate?
2. Fibers in Semen Help HIV Penetrate Cells
3. Beth Israel Deaconess Medical Center Maintains Healthy IT Servers With Third Brigade
4. YMCA of the USA Expands Healthy Communities Initiatives With $6.8 Million Grant from the Robert Wood Johnson Foundation
5. Womens Health The Daily Fix Your Guide to Healthy Habits for Good Nutrition
6. Average Americans Without Health Insurance Are Young and Healthy With Above Average Incomes
7. A Healthy New Year's Resolution for Your Eyes
8. Strikeithealthyfamily.com Provides Parents With Sense of Relief
9. Healthy Eating and Good Nutrition Go Hand-in-Hand in Tight Economic Times
10. Healthy Travel Media Launches Second Edition of Patients Beyond Borders Singapore Edition
11. Nets Provide Fans with Healthy In-Game Snack Option
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
Breaking Medicine Technology: