Navigation Links
HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
Date:10/10/2007

ANN ARBOR, Mich. Researchers have found they can potentially target chemotherapy for breast cancer to only those women most likely to benefit, sparing the majority of patients from unnecessary side effects.

The multicenter study, led by University of Michigan Comprehensive Cancer Center researchers, found women whose breast cancer expressed a protein called HER-2 were most likely to benefit from adding the drug Taxol to the chemotherapy regimen, while women whose tumors were fueled by estrogen but did not express HER-2 did not get any benefit from the added Taxol. About 15 percent to 20 percent of breast cancers express HER-2, and as many as three-quarters of breast cancers are so-called estrogen-receptor-positive.

Results of the study appear in the Oct. 11 issue of the New England Journal of Medicine.

In general, chemotherapy for breast cancer has been a one-size-fits-all approach. Our decision to recommend it is based on whether a woman is at high risk of the breast cancer recurring, without any idea of whether she would benefit from the additional therapy. With this data we hope we will be able to focus chemotherapy on patients whom its most likely to help, says lead study author Daniel Hayes, M.D., clinical director of the breast oncology program at the U-M Comprehensive Cancer Center. Hayes was the lead investigator on the study, which was run by the Cancer and Leukemia Group B through the Breast Cancer Intergroup of North America.

The study looked at tissue samples and data from 1,500 women who had previously participated in a study looking at the benefit of adding Taxol after four cycles of the drugs Adriamycin and Cytoxan, so-called AC chemotherapy. Cancer had spread to the lymph nodes in all of the women, which is a standard indication to recommend chemotherapy. All the women were given AC chemotherapy for four cycles, after which half the women received four cycles of Taxol and the other half did not receive any
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Trastuzumab therapy effective for Breast cancer patients with Her-2/neu positive
2. HER-2 Positive Breast Cancer Patients May Benefit With a Combo Drug Strategy
3. Roche puts in an Application to Use Herceptin for Treatment in Her-2 positive breast cancer
4. When Her Lot is maligned by HER-2, Staying Abreast is Imperative
5. Patient’s perception of health status helps in better recover
6. FDA debates status of decongestant drugs
7. Status of some prescription drugs
8. Low Socioeconomic Status May Lead To Mental Illness
9. Post-Menopausal Status May Cause Tooth Decay
10. Ruling On Non Disclosure Of HIV Positive Status Is Not Ethical
11. Treatment For Prostate Cancer Relapse Linked To Marital Status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... (PRWEB) August 31, 2014 Priya ... NutriGold , expressed concern over misinformation about weight-loss ... conflicting and, quite often, misleading information being propagated ... TV personalities are weighing in on the ... about vitamins, supplements, and especially weight-loss products and ...
(Date:8/31/2014)... Healthy Grid announced the impending release ... lollipops will use herbs to fight the bacteria that cause ... fight bacteria while stimulating saliva production. , “We're very excited ... of Healthy Grid. “Even though personal dental care is on ... little more prevention. Cavities are painful and expensive but these ...
(Date:8/31/2014)... Brook Forest Voices , audiobook producer and ... Short Stories of Wisdom and Kindness from Around the ... Jackson author, speaker, humanitarian and cultural economist. , In ... vast volume of meticulously handwritten notes taken while traveling ... behalf of Project C.U.R.E . Founded in 1987 ...
(Date:8/31/2014)... denervation seems to be more successful at reducing blood ... accessory renal arteries, according to research presented at ESC ... Dr Schmiedel said: "More than one billion people worldwide ... pressure (BP) greater than 140/90 mmHg. Up to 15% ... unable to reduce BP below 140/90 mmHg despite adhering ...
(Date:8/30/2014)... Local anaesthetic is as safe and effective for transcatheter ... results of the FRANCE 2 registry presented at ESC ... Dr Chopard said: "Numerous studies have shown that TAVI ... symptomatic aortic stenosis who are at very high risk ... number of TAVI procedures in France and around the ...
Breaking Medicine News(10 mins):Health News:New Reasons to Verify Label Claims on Weight-loss Products Before Buying 2Health News:New Reasons to Verify Label Claims on Weight-loss Products Before Buying 3Health News:Healthy Grid: Fight Cavities With Sweet Treats 2Health News:Healthy Grid: Fight Cavities With Sweet Treats 3Health News:Brook Forest Voices Announces End of Summer Release! Dr. James Jackson’s, “Simplicity & Sophistication” Audiobook 2Health News:Renal denervation more successful when it includes accessory arteries 2Health News:Local anesthetic for TAVI as safe and effective as general anesthetic 2
... 3 (HealthDay News) -- The impending extinction of various ... important buffer against the transmission of infectious disease, new ... U.S. National Science Foundation and National Institutes of Health,s ... Environmental Protection Agency, focused on how the loss of ...
... findings will be highly useful to the manufacturing industry ... toothpaste, cosmetics, pharmaceuticals and foodstuffs depends on an understanding ... The research just published in Nature ... of Physics and Astronomy, with collaborators at the University ...
... Nearly a quarter of Americans live in rural areas, which ... and suburban areas. Among the complex causes for this disparity ... areas and almost 4 out of 10 rural residents ... Finding the time, transportation, and financial resources for travel ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, ... can cut your risk for first-time stroke by 80 ... Association and the American Stroke Association. Also, as ... care, ER doctors are in a position to identify ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Dec. ... Department of Health and Human Services (HHS) has announced its ... including making dents in rates of obesity, smoking and deaths ... People is to try to move the nation to better ...
... From hotel-style room service to massage therapy to magnificent ... a bid to gain market share, especially those in ... in the New England Journal of Medicine , ... hospital care, explaining that how we decide to value ...
Cached Medicine News:Health News:Species Extinctions May Spell Trouble for Human Health 2Health News:Smashing fluids: The physics of flow 2Health News:ALBERT EINSTEIN COLLEGE OF MEDICINE HELPS ADDRESS NEED FOR IMPROVED CANCER CARE IN RURAL AMERICA 2Health News:Lifestyle Key to Preventing Stroke, Guidelines Say 2Health News:U.S. Government Sets New Health Goals for 2020 2Health News:U.S. Government Sets New Health Goals for 2020 3Health News:Hospital perks: How much should hospitals be rewarded for the patient experience? 2
(Date:8/29/2014)... , Aug. 29, 2014 The Competitive ... regulatory and marketplace changes. CI leaders who adjust will ... In a new Best Practices, LLC study CI ... actionable insights, including: - Use secondary research ... primary research - Internal staff who are ...
(Date:8/29/2014)... , Aug. 29, 2014  A Boston ... multinational study on stent removability and preliminary long ... been published in the August issue of the ... study 1 is being conducted in 11 ... fully covered self-expanding metal stents (FCSEMS) after extended ...
(Date:8/29/2014)... Thoratec Corporation (NASDAQ: THOR ), ... to save, support and restore failing hearts, said today ... Global Healthcare Conference on Wednesday, September 10. ... Officer, will provide an update on the company, beginning ... Daylight Time).   A webcast of the ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... March 26, 2012   Sigma-Aldrich ® Corporation (Nasdaq: ... of Europe,s Top Employers by the Corporate Research ... business journalists, trade associations, researchers and international publishers ... acknowledgement.  Sigma-Aldrich is one of nine companies that ...
... -- Pennystocksinsiders.com (PSI) has issued insider trading reports and ... Atmel (NASDAQ: ATML), USG (NYSE: USG), Applied Materials (NASDAQ: ... and Key Energy Services (NYSE: KEG). ... report by clicking the link below, you may need ...
Cached Medicine Technology:CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 2CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 3Equity Research on Most Popular Searches: Atmel, USG, Applied Materials, Sprint Nextel, Galena Biopharma, and Key Energy Services 2Equity Research on Most Popular Searches: Atmel, USG, Applied Materials, Sprint Nextel, Galena Biopharma, and Key Energy Services 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: