Navigation Links
H7N9 influenza virus not adapted to efficient human-to-human transmission
Date:12/6/2013

WHAT:

The avian H7N9 influenza virus that emerged earlier this year in China is poorly adapted for sustained transmission between humans, suggesting that the current form of the virus is unlikely to cause a pandemic, according to a new study led by Ian A. Wilson, Ph.D., and James C. Paulson, Ph.D., of The Scripps Research Institute (TSRI). The study, published today in Science, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and other organizations.

As of November 6, 139 confirmed human cases of avian H7N9 influenza, including 45 deaths, have been reported by the World Health Organization. Most of these cases have been linked to exposure to infected poultry, but in some cases, limited human-to-human transmission may have occurred. In this study, the TSRI scientists examined the three-dimensional structures of the hemagglutinin (HA) protein on the surface of the virus and its interaction with the human influenza receptorthe molecule on the surface of human cells that HA binds to before entering the cell and causing infection. Previous research had shown that compared to influenza viruses that are adapted to spread easily among birds, viruses adapted to humans generally have different amino acids (protein components) at the HA site that recognize and bind to the human receptor. Recent studies have shown that certain H7N9 viruses had acquired mutations that might make them more adapted to humans. However, using X-ray crystallography to study the HA and receptor structures with unprecedented accuracy, the TSRI researchers demonstrated that the HA in avian H7N9 influenza most closely resembles that of viruses that spread easily among birds, yet only weakly attaches to human influenza receptors.

Although it is not impossible that the H7N9 virus could eventually become transmissible from person to person, it would need to undergo multiple other mutations to do so, the study authors write.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. National Foundation for Infectious Diseases Supports 2013 National Influenza Vaccination Week
2. 1950s pandemic influenza virus remains a health threat, particularly to those under 50
3. Rapid testing to diagnose influenza leads to more appropriate care in the ED
4. Bel Marra Health Reports on Recent Research Reveals That the Flu Shot May Protect Against Both Influenza and Heart Attack
5. BCC Research Publishes a New Report on Global Markets for Influenza Products
6. Study Finds Infants Under 6 Months Too Young for Flu Shot at High Risk to Influenza Fatalities- UV Technologies Makers of UV-Aid, Develop New Flu Prevention Alternative
7. China Avian Influenza Vaccine Industry 2013 Analysis & 2017 Forecasts in New Research Report at ChinaMarketResearchReports.com
8. Reassuring findings for mothers who have influenza vaccine while pregnant
9. China Haemophilus Influenza B (HIB) Vaccine Market 2017 Forecasts in New Research Now Available at MarketReportsOnline.com
10. NIH clinical study establishes human model of influenza pathogenesis
11. Pain-free microneedle influenza vaccine is effective, long-lasting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Southern Illinois University School ... for the Illinois State Dental Society (ISDS) Foundation’s Mission of Mercy (MOM). They ... Center in Collinsville. , They expect to treat approximately 2,000 patients ...
(Date:6/23/2016)... ... June 23, 2016 , ... An article ... a possible link between head and neck cancer in individuals with unhealthy oral hygiene ... were evaluated based on whether they had gum disease, brushed their teeth on a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... 23, 2016 Leading BioSciences Inc., a ... conditions resulting from a breakdown of the mucosal ... Greg Doyle as chief executive officer. Mr. ... management team and board of directors, previously served ... He will provide continued leadership and strategic direction ...
Breaking Medicine Technology: