Navigation Links
H7N9 influenza virus not adapted to efficient human-to-human transmission
Date:12/6/2013

WHAT:

The avian H7N9 influenza virus that emerged earlier this year in China is poorly adapted for sustained transmission between humans, suggesting that the current form of the virus is unlikely to cause a pandemic, according to a new study led by Ian A. Wilson, Ph.D., and James C. Paulson, Ph.D., of The Scripps Research Institute (TSRI). The study, published today in Science, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and other organizations.

As of November 6, 139 confirmed human cases of avian H7N9 influenza, including 45 deaths, have been reported by the World Health Organization. Most of these cases have been linked to exposure to infected poultry, but in some cases, limited human-to-human transmission may have occurred. In this study, the TSRI scientists examined the three-dimensional structures of the hemagglutinin (HA) protein on the surface of the virus and its interaction with the human influenza receptorthe molecule on the surface of human cells that HA binds to before entering the cell and causing infection. Previous research had shown that compared to influenza viruses that are adapted to spread easily among birds, viruses adapted to humans generally have different amino acids (protein components) at the HA site that recognize and bind to the human receptor. Recent studies have shown that certain H7N9 viruses had acquired mutations that might make them more adapted to humans. However, using X-ray crystallography to study the HA and receptor structures with unprecedented accuracy, the TSRI researchers demonstrated that the HA in avian H7N9 influenza most closely resembles that of viruses that spread easily among birds, yet only weakly attaches to human influenza receptors.

Although it is not impossible that the H7N9 virus could eventually become transmissible from person to person, it would need to undergo multiple other mutations to do so, the study authors write.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. National Foundation for Infectious Diseases Supports 2013 National Influenza Vaccination Week
2. 1950s pandemic influenza virus remains a health threat, particularly to those under 50
3. Rapid testing to diagnose influenza leads to more appropriate care in the ED
4. Bel Marra Health Reports on Recent Research Reveals That the Flu Shot May Protect Against Both Influenza and Heart Attack
5. BCC Research Publishes a New Report on Global Markets for Influenza Products
6. Study Finds Infants Under 6 Months Too Young for Flu Shot at High Risk to Influenza Fatalities- UV Technologies Makers of UV-Aid, Develop New Flu Prevention Alternative
7. China Avian Influenza Vaccine Industry 2013 Analysis & 2017 Forecasts in New Research Report at ChinaMarketResearchReports.com
8. Reassuring findings for mothers who have influenza vaccine while pregnant
9. China Haemophilus Influenza B (HIB) Vaccine Market 2017 Forecasts in New Research Now Available at MarketReportsOnline.com
10. NIH clinical study establishes human model of influenza pathogenesis
11. Pain-free microneedle influenza vaccine is effective, long-lasting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... PA (PRWEB) , ... March 23, 2017 , ... ... comprehensive educational training program owned and organized by HMP Communications Holdings, LLC, today ... program for physicians within its nationwide network of wound centers interested in becoming ...
(Date:3/23/2017)... ... 2017 , ... March 23, 2017 - Crawford Technologies announced ... customer invoices, bills, statements and other correspondence when they have been lost or ... and print the documents and batch them for efficient handling. , Many ...
(Date:3/23/2017)... ... ... conference will prominently feature 150+ Hospital and Health System Executive Speakers including: , ... 43rd President of the United States of America: George W. Bush , ... the Ring: Sugar Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh ...
(Date:3/23/2017)... ... 2017 , ... According to the National Sleep Foundation , poor sleep ... only cause of the sunken-eye look, which can include dark circles or bags under ... health are likely due to genetics, dehydration, allergies, and losing fat beneath the thin ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... Inflow IQ ... Life is serious so build on a solid foundation. As experts in dangerous ... vital information that is coming soon. Inflownomics deliver ripe, fresh, clean & refreshing knowledge ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 On ... the trading session at 5,821.64, up 0.48%; the ... finish at 20,661.30; and the S&P 500 closed ... based as six out of nine sectors ended ... initiated reports coverage on the following Medical Instruments ...
(Date:3/23/2017)... , March 23, 2017 BioLineRx Ltd. ... immunology, announced today that it has acquired Agalimmune Ltd., a ... consideration consisted of a $6 million upfront payment, of which ... shares. Additional future payments may be made based on development ... ...
(Date:3/23/2017)... AVIV, Israel, March 23, 2017  Galmed Pharmaceuticals ... the "Company"), a clinical-stage biopharmaceutical company focused on ... the treatment of nonalcoholic steatohepatitis, or NASH, and ... the three and twelve months ended December 31, 2016, ... completed pre-clinical studies demonstrating Aramchol™,s potential direct effect ...
Breaking Medicine Technology: