Navigation Links
H7N9 influenza virus not adapted to efficient human-to-human transmission


The avian H7N9 influenza virus that emerged earlier this year in China is poorly adapted for sustained transmission between humans, suggesting that the current form of the virus is unlikely to cause a pandemic, according to a new study led by Ian A. Wilson, Ph.D., and James C. Paulson, Ph.D., of The Scripps Research Institute (TSRI). The study, published today in Science, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and other organizations.

As of November 6, 139 confirmed human cases of avian H7N9 influenza, including 45 deaths, have been reported by the World Health Organization. Most of these cases have been linked to exposure to infected poultry, but in some cases, limited human-to-human transmission may have occurred. In this study, the TSRI scientists examined the three-dimensional structures of the hemagglutinin (HA) protein on the surface of the virus and its interaction with the human influenza receptorthe molecule on the surface of human cells that HA binds to before entering the cell and causing infection. Previous research had shown that compared to influenza viruses that are adapted to spread easily among birds, viruses adapted to humans generally have different amino acids (protein components) at the HA site that recognize and bind to the human receptor. Recent studies have shown that certain H7N9 viruses had acquired mutations that might make them more adapted to humans. However, using X-ray crystallography to study the HA and receptor structures with unprecedented accuracy, the TSRI researchers demonstrated that the HA in avian H7N9 influenza most closely resembles that of viruses that spread easily among birds, yet only weakly attaches to human influenza receptors.

Although it is not impossible that the H7N9 virus could eventually become transmissible from person to person, it would need to undergo multiple other mutations to do so, the study authors write.


Contact: Nalini Padmanabhan
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. National Foundation for Infectious Diseases Supports 2013 National Influenza Vaccination Week
2. 1950s pandemic influenza virus remains a health threat, particularly to those under 50
3. Rapid testing to diagnose influenza leads to more appropriate care in the ED
4. Bel Marra Health Reports on Recent Research Reveals That the Flu Shot May Protect Against Both Influenza and Heart Attack
5. BCC Research Publishes a New Report on Global Markets for Influenza Products
6. Study Finds Infants Under 6 Months Too Young for Flu Shot at High Risk to Influenza Fatalities- UV Technologies Makers of UV-Aid, Develop New Flu Prevention Alternative
7. China Avian Influenza Vaccine Industry 2013 Analysis & 2017 Forecasts in New Research Report at
8. Reassuring findings for mothers who have influenza vaccine while pregnant
9. China Haemophilus Influenza B (HIB) Vaccine Market 2017 Forecasts in New Research Now Available at
10. NIH clinical study establishes human model of influenza pathogenesis
11. Pain-free microneedle influenza vaccine is effective, long-lasting
Post Your Comments:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: