Navigation Links
H1N1 Virus Yields Up More Secrets

Current strain is similar to that seen in 1918, with implications for vaccine development, scientists say

WEDNESDAY, March 24 (HealthDay News) -- The 2009 H1N1 "swine flu" virus shares remarkable similarities with strains that were rampant early in the 20th century, two teams of scientists report.

These structural similarities help explain why older people seemed to be less affected by H1N1 during the latest pandemic, researchers say, and they also point the way to better vaccines against the strain.

In one report, published in the March 25 online edition of Science, a team at The Scripps Research Institute and elsewhere say that the structure of the hemagglutinin (the influenza virus envelope protein) found on H1N1 is very similar to that of strains seen almost 100 years ago.

"Parts of the 2009 virus are remarkably similar to human H1N1 viruses circulating in the early 20th century," study senior author and Scripps professor Ian Wilson said in an institute news release. "Our findings provide strong evidence that exposure to earlier viruses has helped to provide some people with immunity to the recent influenza pandemic."

One area of hemagglutinin, especially, known as antigenic site Sa, appears highly similar between the 2009 and 1918 strains of influenza. The 1918 flu pandemic killed millions worldwide.

In a separate report, scientists have discovered that the 1918 and 2009 pandemic influenza viruses share a key structural detail -- both lack a cap of sugar molecules in a certain area -- that makes them susceptible to the same antibodies.

It may be possible to exploit this vulnerability to design new vaccines, according to a team led by Dr. Gary J. Nabel of the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health.

The discovery was made in a series of experiments with mice and computer modeling studies.

"This study defines an unexpected similarity between two pandemic-causing strains of influenza. It gives us a new understanding of how pandemic viruses evolve into seasonal strains and, importantly, provides direction for developing vaccines to slow or prevent that transformation," Dr. Anthony S. Fauci, director of NIAID, said in an agency news release.

Those findings were published online March 24 in the journal Science Translational Medicine.

More information has more about flu pandemics.

-- Robert Preidt

SOURCE: U.S. National Institute of Allergy and Infectious Diseases, news release, March 24, 2010; The Scripps Research Institute, news release, March 24, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Asks Docs to Suspend Using Glaxo Rotavirus Vaccine
2. GlaxoSmithKline Statement on New Information Relating to Manufacture of Rotarix (Rotavirus Vaccine)
3. Reovirus may be a novel approach to prostate cancer treatment
4. Infectious Virus Hides In Human Chromosomes During Latency And Can Be Passed From Parents To Their Children
5. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
6. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
7. Virus Unlikely to Cause Chronic Fatigue Syndrome
8. Chronic Fatigue Syndrome-Virus Link Questioned
9. Researchers find broad spectrum antiviral that fights multitude of viruses
10. Compound found that targets wide range of viruses
11. Virus-like particle vaccine protects monkeys from chikungunya virus
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent Applied Drug ... need to integrate dose form selection in early phase drug development. The first ... supporting and bringing together the UK’s emerging life sciences companies, corporate partners, and ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is ... 2015, our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an ... every day excited to rebuild lives and it’s an honor to have served all ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel Film ... trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with 30 ... with any font, giving users limitless opportunities to stylize and create designs quickly ...
(Date:11/26/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class Asterisk based contact ... and reliability. , The new Q-Suite 6 platform is based on the latest Java ... into a specific piece of software for many key components of the suite. Much ...
(Date:11/25/2015)... Indianapolis, IN (PRWEB) , ... November 25, 2015 ... ... clean water accessible for all, Water For Empowerment ™ attracts volunteers together ... on clean water by empowering women as key stakeholders in the process. The ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
(Date:11/25/2015)... Asia -based venture ... and the New Investors will make a direct equity ... private placement. The financing will help IOPtima to continue ... in the treatment of glaucoma, as well as to ... system with the U.S. Food and Drug Administration, commencing ...
(Date:11/25/2015)... , November 25, 2015 Developmental, commercial, ... in boosting the profitability of pharmaceutical products, says ... and regulatory/legal strategies all play a key ... says GBI Research . --> ... a key role in boosting the profitability of pharmaceutical products, ...
Breaking Medicine Technology: