Navigation Links
H1N1 Virus Yields Up More Secrets
Date:3/24/2010

Current strain is similar to that seen in 1918, with implications for vaccine development, scientists say

WEDNESDAY, March 24 (HealthDay News) -- The 2009 H1N1 "swine flu" virus shares remarkable similarities with strains that were rampant early in the 20th century, two teams of scientists report.

These structural similarities help explain why older people seemed to be less affected by H1N1 during the latest pandemic, researchers say, and they also point the way to better vaccines against the strain.

In one report, published in the March 25 online edition of Science, a team at The Scripps Research Institute and elsewhere say that the structure of the hemagglutinin (the influenza virus envelope protein) found on H1N1 is very similar to that of strains seen almost 100 years ago.

"Parts of the 2009 virus are remarkably similar to human H1N1 viruses circulating in the early 20th century," study senior author and Scripps professor Ian Wilson said in an institute news release. "Our findings provide strong evidence that exposure to earlier viruses has helped to provide some people with immunity to the recent influenza pandemic."

One area of hemagglutinin, especially, known as antigenic site Sa, appears highly similar between the 2009 and 1918 strains of influenza. The 1918 flu pandemic killed millions worldwide.

In a separate report, scientists have discovered that the 1918 and 2009 pandemic influenza viruses share a key structural detail -- both lack a cap of sugar molecules in a certain area -- that makes them susceptible to the same antibodies.

It may be possible to exploit this vulnerability to design new vaccines, according to a team led by Dr. Gary J. Nabel of the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health.

The discovery was made in a series of experiments with mice and computer modeling studies.

"This study defines an unexpected similarity between two pandemic-causing strains of influenza. It gives us a new understanding of how pandemic viruses evolve into seasonal strains and, importantly, provides direction for developing vaccines to slow or prevent that transformation," Dr. Anthony S. Fauci, director of NIAID, said in an agency news release.

Those findings were published online March 24 in the journal Science Translational Medicine.

More information

Flu.gov has more about flu pandemics.



-- Robert Preidt



SOURCE: U.S. National Institute of Allergy and Infectious Diseases, news release, March 24, 2010; The Scripps Research Institute, news release, March 24, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Asks Docs to Suspend Using Glaxo Rotavirus Vaccine
2. GlaxoSmithKline Statement on New Information Relating to Manufacture of Rotarix (Rotavirus Vaccine)
3. Reovirus may be a novel approach to prostate cancer treatment
4. Infectious Virus Hides In Human Chromosomes During Latency And Can Be Passed From Parents To Their Children
5. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
6. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
7. Virus Unlikely to Cause Chronic Fatigue Syndrome
8. Chronic Fatigue Syndrome-Virus Link Questioned
9. Researchers find broad spectrum antiviral that fights multitude of viruses
10. Compound found that targets wide range of viruses
11. Virus-like particle vaccine protects monkeys from chikungunya virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... 29, 2016 , ... For those who skip meals occasionally (which is pretty ... among the many new lifestyle diet tips offered by nutritionists Pam Bonney and Priya ... Water® radio show. Bonny and Lawrence noted that because proper nutrition, including water, provides ...
(Date:4/29/2016)... ... April 29, 2016 , ... Innovations with Ed Begley Jr., ... episode, airing third quarter 2016 via Discovery Channel. Dates and show times TBA. ... Products, located in Greenwood, Wisconsin applies product research and development and continuous technological ...
(Date:4/29/2016)... ... April 29, 2016 , ... CURE Media Group ... patients with cancer, today announced that Lynne Malestic, RN, of Eisenhower Lucy Curci ... Extraordinary Healer® for Oncology Nursing , which honors nurses who have dedicated their ...
(Date:4/29/2016)... Rafael, CA (PRWEB) , ... April 29, 2016 , ... ... week long softball camp from July 24th – 27th for girls aged 10-18. All ... camp is held at the beautiful Clark V. Whited Complex, one of the finest ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... George Phillips und Stephen ...    ArisGlobal®, ein führender Anbieter ... gab heute bekannt, dass neue Führungskräfte zum ... gestoßen sind, die vielfältige Erfahrungen mitbringen.  Dies ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... of oral drug delivery systems, announced today that the Company ... Joseph Gunnar & Co. LLC, taking place on ... Nadav Kidron , CEO of Oramed, will present a ...   PIONEERS 2016, presented by Joseph Gunnar ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
Breaking Medicine Technology: