Navigation Links
Gut worms may protect against house-dust mite allergy
Date:9/28/2009

A study conducted in Vietnam has added further weight to the view that parasitic gut worms, such as hookworm, could help in the prevention and treatment of asthma and other allergies.

Led by Dr Carsten Flohr, a Clinical Scientist from The University of Nottingham, and Dr Luc Nguyen Tuyen from the Khanh Hoa Provincial Health Service in central Vietnam, the study is the largest double-blind placebo controlled clinical trial to date looking at the potential links between hookworm and other gut worm infections and allergic conditions such as asthma and eczema.

Thanks to improved hygiene practices parasitic worms have been mostly eradicated among human populations living in developed countries. However, experts believe that over millions of years of co-evolution worms have found methods to dampen down host immune responses to prolong their own survival inside humans. This relationship seems to have become so intertwined that without gut worms or other parasites, our immune system can become unbalanced, which in turn could contribute to the development of asthma and other allergies. At the same time, it is important to remember that gut parasites can cause severe disease and are a major cause of iron-deficiency anaemia in developing countries.

Dr Flohr's study was conducted in a rural area of central Vietnam where two out of three children have hookworm and other gut parasite infections and where allergies are extremely rare. More than 1,500 schoolchildren aged 6-17 took part.

The team investigated whether repeated tablet treatments to clear the body of gut worms made it more likely for children to develop allergic conditions. While the treatment did not demonstrate an effect on asthma or eczema, the treated children had a significantly increased risk of having a positive allergy skin test to house-dust mites and cockroach. This suggests that gut worms have the potential to tone down human immune responses and so further research is now needed to identify precisely how gut worm infection can prevent allergic sensitisation.

Dr Carsten Flohr of The University of Nottingham adds: "The next step is to understand exactly how and when gut parasites programme the human immune system in a way that protects against allergic sensitisation, and for such studies, follow-up from birth will be essential."

As up to 80 per cent of people with asthma also have allergies to house-dust mites and other environmental allergens, additional research in this area could aid the creation of new treatments that work in the same way as gut parasites, by dampening down or rebalancing the immune system so that the body does not respond to allergens and trigger asthma attacks.

Dr Elaine Vickers, Research Relations Manager at Asthma UK, says: "Asthma affects more than five million people in the UK, with a person being admitted to hospital every seven minutes following an asthma attack. The prospects of further studies in this area are therefore very exciting as we could see groundbreaking treatments for asthma and other allergies developed as a result. It's now vital that we see more funding being invested in this important area of research, so that we can increase our understanding of the link between gut parasites and the development of allergies from birth."

Co-applicants on the Asthma UK research grant that funded the work were Professors John Britton, David Pritchard, and Hywel Williams. The Nottingham team collaborated with researchers from the Wellcome Trust Major Overseas Programme at the Oxford University Clinical Research Unit Hospital for Tropical Diseases in Ho Chi Minh City, where Dr Flohr was based for his work. Additional funding was received through the Bastow Award from the Special Trustees for Nottingham University Hospitals. Dr Flohr's salary was provided by University College, University of Oxford, for two years and by the Wellcome Trust UK for a further nine months.


'/>"/>

Contact: Dr. Carsten Flohr
carsten.flohr@nottingham.ac.uk
44-020-778-64949
University of Nottingham
Source:Eurekalert

Related medicine news :

1. CDC Reports Prevalence of Worms Transmitted by Dogs and Cats to Humans is Higher Than Previously Understood
2. Iron banded worms drying out of blood could be linked to Parkinsons and Alzheimers
3. UC San Diego researchers target tumors with tiny nanoworms
4. Warmer Weather Reminds Cat Owners to Protect Against Worms
5. Ben-Gurion University of the Negev initiates project to eliminate intestinal worms in Ethiopia
6. Hookworms in MS trial
7. Worms Reveal More of Longevitys Secrets
8. Worms Control Lifespan at High Temperatures, UCSF Study Finds
9. Survey reveals disparities in skin cancer knowledge, protection among high school students
10. Scientists Develop Natural Protection for Stored Foods
11. Despite overeating, morbidly obese mice gain protection against diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... ... ... PITTSBURGH...An inventor, from Richmond Hill, Ga., thought there needed to be a quick ... invented the COMPLETE PATIENT CHART. , The COMPLETE PATIENT CHART provides a more effective ... alternative to paper charts and clipboards. As a result, it increases efficiency and it ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... science and technology-enabled services supporting clinical research, today announces that 30 of ... aspects of the drug development lifecycle at upcoming industry conferences and webinars. ...
(Date:9/25/2017)... ... September 25, 2017 , ... Earlypicker is expanding its offerings to include ... the hottest Korean cosmetics and fashion trends sweeping the nation. The decision to expand ... for the great offerings that allow Koreans everywhere to look their best every single ...
(Date:9/25/2017)... ... September 25, 2017 , ... “The Majestic Unicorn”: a poignant ... “The Majestic Unicorn” is the creation of published author, Dayna Chantel, an artist and ... far and wide to march aboard the cypress ark-vessel. Male and female, no matter ...
(Date:9/25/2017)... ... ... kill Ash trees in as little as 1-3 years. The signs of this ... Nagy, ISA Certified Arborist at Giroud Tree and Lawn, shows a street in Northeast Philadelphia ... decline from Emerald Ash Borers, two Ash trees continue to thrive. , "The ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... ANTONIO , Sept. 6, 2017  Robert G. ... a Pinnacle Professional Member in recognition of his contributions ... Szewc serves as a Nephrologist at the practice of ... emergency medicine, kidney care and hypertension solutions. He has ... 20 years of career experience, as well as expertise ...
(Date:9/5/2017)... -- Sapheneia and Scannerside received FDA 510(k) clearance to ... third-party Vendor neutral CT product that makes it affordable ... current MITA standards. ... specifically designed to provide CT operators, prior to a ... a predefined threshold. Scannerside Dose Check is intended to ...
(Date:9/1/2017)... 1, 2017 Michael Penna , President ... highlights opportunities for growth in his response to the ... Equity is seeking a buyer for eMDs. Penna,s company, ... healthcare solutions Value Added Reseller and national leader in ... "As the healthcare market continues to dictate ...
Breaking Medicine Technology: