Navigation Links
Gut microbes spur development of bowel cancer
Date:3/3/2014

It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice published in the March issue of The Journal of Experimental Medicine.

Bowel cancer, also called colorectal cancer, results from a series of genetic changes (mutations) that cause healthy cells to become progressively cancerous, first forming early tumors called polyps that can eventually become malignant. Although mutations can occur anywhere in the human intestine, certain types of colorectal cancer tend to develop in particular locations, suggesting that additional, nongenetic factors contribute to tumor growth and dictate where polyps appear.

Dr. Sergio Lira and his team at the Icahn School of Medicine at Mount Sinai, New York, asked if gut microbes have a hand in tumor development. The researchers had noticed previously that mice carrying polyp-causing mutations develop polyps only in a limited section of the intestine, despite the mutations being present in all cells along the intestine. In the new study, they treated the mice with antibiotics to disrupt the populations of microbes living in their gut. This treatment prevented the formation of polyps, showing that bacteria are essential for early tumor development in this model. The authors propose that bacteria cross from the gut into the tissue of the intestinal wall, triggering inflammation that promotes tumor growth.

While further research is needed to confirm the identity of the cancer-promoting bacteria, the findings suggest it may be possible to reduce the risk of colorectal cancer in genetically susceptible individuals by removing certain types of gut bacteria.

The work may also help explain some of the nongenetic factors that have been implicated in colorectal cancer. "In addition to genetic changes, various lifestyle-related factors, such as obesity and diet, have been linked to colorectal cancer. Some of these lifestyle factors appear to affect the types of bacteria present in the gut," explains Dr Lira. "Ultimately, understanding the interplay between genetic mutations, gut microbes, and inflammation may lead to novel diagnostics and therapies for intestinal cancer."


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Related medicine news :

1. Taming microbes to combat antibiotic resistance
2. Gut microbes may be a risk factor for colorectal cancer
3. New Technology Automatically Sterilizes Dangerous Microbes at Point of Sale Terminals
4. Through New Innovative Measures, Highly Pathogenic Microbes Will Now Be Tested Clinically, Strengthening The Front Line In The Fight Against Food-Borne Illness
5. New biochip technology uses tiny whirlpools to corral microbes
6. University of Tennessee study: Unexpected microbes fighting harmful greenhouse gas
7. Weapon-wielding marine microbes may protect populations from foes
8. Gut Microbes Might Reflect Health, Diet of Older Adults
9. Scientists Probe Diversity of Human Bodys Microbes
10. GW spirituality and health pioneer publishes paper on development of the field
11. Penn Medicine: Cognitive development growth charts may help diagnose and treat psychosis-risk kids
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gut microbes spur development of bowel cancer
(Date:5/2/2016)... ... May 02, 2016 , ... Pregnancy Awareness Month offers a great time ... , “If you are ready to have a baby, it’s best to get ... Journal Babies is your Personal Conception & Pregnancy Organizer, written for women who plan ...
(Date:5/2/2016)... ... May 02, 2016 , ... Consultative health ... and GM Jim Callandrillo and Duane Reed, VP of business development of AJMC ... Intelligence and Research Group (PBIRG) General Meeting from May 15-17 at the ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... For many ... performance artist Curt Walter has developed it into a science. , Using the ... Walter achieve subtly differentiated shades that add depth and meaning to his works. What’s ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... today announced the opening of Twin Lakes Recovery Center. Located east of ... in the state. The residential facility is set on 34 acres of ...
(Date:5/1/2016)... ... May 02, 2016 , ... ... 1968 Jimi Hendrix Merriweather Post Pavilion in Columbia, Maryland concert posters. Dail Beeghley ... The concert was held on August 16. According to Hawley, “The Pavilion was ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... 2, 2016  While nearly three-quarters of Americans (71%) ... on their health, only about half report taking any ... results of a new survey announced today by Hologic ... of National Osteoporosis Month, Hologic is raising awareness of ... 56 million Americans. Osteoporosis is a disease ...
(Date:4/29/2016)... , April 29, 2016  In the ... projected to shift from systems dependent on CRTs monitors ... types of modality CRT Medical monitors and will ... are a host of foreseeable benefits to this ... will existing modalities have to be replaced in ...
(Date:4/29/2016)... April 29, 2016 ... Financier Sanofi, leader mondial ... ses résultats pour le premier trimestre ... Jérôme Contamine, commente les résultats du ... perspectives pour le reste de l,année. ...
Breaking Medicine Technology: