Navigation Links
Gut microbes promote cell turnover by a well-known pathway
Date:10/7/2010

Microbes matter -- perhaps more than anyone realizes -- in basic biological development and, maybe, they could be a target for reducing cancer risks, according to University of Oregon researchers.

In a study of very basic biology of zebrafish, scientists in the UO Institute of Molecular Biology focused on the developing intestine during its early formation in the sterile environment of its eggshell through the exposure to natural colonizing bacteria after hatching.

What they found was eye opening, said Karen Guillemin, professor of biology: Resident microbes in the still-maturing intestine send messages that promote non-disease-related cell proliferation in the same Wnt [pronounced went] signaling pathway where genetic mutations have long been known to give rise to colorectal cancer. The findings appeared online ahead of regular publication in the Proceedings of the National Academy of Sciences.

The complex Wnt pathway in the gut already is considered the starting point for more than 70 percent of sporadic colorectal cancers. In the study, researchers used normal zebrafish and those harboring mutations in the Wnt pathway. They were reared under germ-free conditions and then exposed under laboratory conditions to specific microbes to define how microbial signals interact with the Wnt pathway to promote cell proliferation in the gut.

"We were able to show that microbial signals do feed into and enhance signaling in the Wnt pathway. They feed in at a point after the node where most cancer-promoting genetic mutations occur," Guillemin said. "What this says is that for anyone who is at risk for developing cancer because they have these mutations, it matters what microbes these mutations are associated with. These two pieces of information contribute in parallel and feed into the same pathway."

The findings, she said, add fodder in an emerging shift in cancer research to look at the impact of microbes and other infectious causes of the disease. "It may be that associated microbes play as significant a role in cancer risk as genetic mutations," she said. "We need to learn more about the contributions of microbe signaling to cell proliferation. Maybe you could intervene with a targeted therapy. Even if you can't fix a mutation you might manipulate the associated microbes to change the interaction and reduce unwanted cell proliferation."

Genetic research on zebrafish a high-priority model organism for the National Institutes of Health, which supported the project began at the UO in the early 1970s. Guillemin, who recently received an early career investigator-scholar award from the NIH Institute of Digestive and Kidney Diseases, is known for her studies in zebrafish on the role of good bacteria in the gastrointestinal tract.


'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert  

Related medicine news :

1. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
2. Study reveals a secret to the success of notorious, disease-causing microbes
3. New weapon against highly resistant microbes within grasp
4. Scientists Map Genetic Codes of Human Microbes
5. You Are What Microbes You Eat
6. ASTRO, Emilio Nares Foundation join to promote cancer survivorship
7. Individual mutations are very slow to promote tumor growth
8. Difficult Dialogues Initiative promotes diversity at MU, around country
9. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
10. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
11. Interventions to promote repeat breast cancer screening with mammography
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gut microbes promote cell turnover by a well-known pathway
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... , ... June 24, 2016 , ... National recruitment firm ... life sciences executive with extensive sequencing and genomics experience, as Vice President of North ... Ms. Hill will be responsible for leading the sales team in the commercialization of ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 One of ... has announced the formation of a new biotechnology company, Noxopharm Limited ... $6m in an IPO and to list on the ASX. ... candidate, NOX66, ready to enter a Phase 1 clinical study later ... designed to address one of the biggest problems facing cancer patients ...
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
Breaking Medicine Technology: