Navigation Links
Gut microbes promote cell turnover by a well-known pathway

Microbes matter -- perhaps more than anyone realizes -- in basic biological development and, maybe, they could be a target for reducing cancer risks, according to University of Oregon researchers.

In a study of very basic biology of zebrafish, scientists in the UO Institute of Molecular Biology focused on the developing intestine during its early formation in the sterile environment of its eggshell through the exposure to natural colonizing bacteria after hatching.

What they found was eye opening, said Karen Guillemin, professor of biology: Resident microbes in the still-maturing intestine send messages that promote non-disease-related cell proliferation in the same Wnt [pronounced went] signaling pathway where genetic mutations have long been known to give rise to colorectal cancer. The findings appeared online ahead of regular publication in the Proceedings of the National Academy of Sciences.

The complex Wnt pathway in the gut already is considered the starting point for more than 70 percent of sporadic colorectal cancers. In the study, researchers used normal zebrafish and those harboring mutations in the Wnt pathway. They were reared under germ-free conditions and then exposed under laboratory conditions to specific microbes to define how microbial signals interact with the Wnt pathway to promote cell proliferation in the gut.

"We were able to show that microbial signals do feed into and enhance signaling in the Wnt pathway. They feed in at a point after the node where most cancer-promoting genetic mutations occur," Guillemin said. "What this says is that for anyone who is at risk for developing cancer because they have these mutations, it matters what microbes these mutations are associated with. These two pieces of information contribute in parallel and feed into the same pathway."

The findings, she said, add fodder in an emerging shift in cancer research to look at the impact of microbes and other infectious causes of the disease. "It may be that associated microbes play as significant a role in cancer risk as genetic mutations," she said. "We need to learn more about the contributions of microbe signaling to cell proliferation. Maybe you could intervene with a targeted therapy. Even if you can't fix a mutation you might manipulate the associated microbes to change the interaction and reduce unwanted cell proliferation."

Genetic research on zebrafish a high-priority model organism for the National Institutes of Health, which supported the project began at the UO in the early 1970s. Guillemin, who recently received an early career investigator-scholar award from the NIH Institute of Digestive and Kidney Diseases, is known for her studies in zebrafish on the role of good bacteria in the gastrointestinal tract.


Contact: Jim Barlow
University of Oregon

Related medicine news :

1. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
2. Study reveals a secret to the success of notorious, disease-causing microbes
3. New weapon against highly resistant microbes within grasp
4. Scientists Map Genetic Codes of Human Microbes
5. You Are What Microbes You Eat
6. ASTRO, Emilio Nares Foundation join to promote cancer survivorship
7. Individual mutations are very slow to promote tumor growth
8. Difficult Dialogues Initiative promotes diversity at MU, around country
9. Gold Standard/Elsevier promotes medication safety and compliance via New MEDcounselor languages
10. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
11. Interventions to promote repeat breast cancer screening with mammography
Post Your Comments:
Related Image:
Gut microbes promote cell turnover by a well-known pathway
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... lecturer at a University of Delaware Accounting and Management of Information Systems course. ... solutions for mid-market businesses. Sommer will speak at before student in the Enterprise ...
(Date:11/30/2015)... Doylestown, PA (PRWEB) , ... November 30, 2015 , ... ... the 15th annual Regional Biotech Conference, organized by the Baruch S. Blumberg Institute. , ... than 100 of the area’s life science and biotechnology leaders for the conference, which ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... teams looking to maximize recovery through quality sleep. Tim DiFrancesco, training coach for ... a better night’s sleep. ChiliPad precisely regulates the surface temperature of each side ...
(Date:11/30/2015)... NJ (PRWEB) , ... November 30, 2015 , ... Dr. ... With three office locations, patients can visit Dr. Margulies to experience the best available ... to hold the title of "NJ Top Dentist"! , Orthodontics is the branch of ...
(Date:11/30/2015)... ... November 30, 2015 , ... The recently published 32nd ... System (NPDS) reveals that in 2014, someone called a poison center about every ... of which were human exposure cases. , The American Association of Poison Control ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... REDWOOD CITY, Calif. , Nov. 30, 2015 ... company that is providing innovative evidence-based solutions for the treatment ... Appeals Board (PTAB) at the U.S. Patent and Trademark Office ... (IPR) of U.S. Patent No. 8,359,102 (the ,102 patent).  ... 14, 2015, a unit of Boston Scientific Corporation filed two ...
(Date:11/30/2015)... AMSTERDAM , Nov. 30, 2015   ... today announced the launch of Radiology Solutions, a ... management. Radiology Solutions comprises customized, data-driven practice management ... analytics to help radiology practices improve care delivery ... 2015 Radiological Society of North America Annual ...
(Date:11/30/2015)... AMSTERDAM , Nov. 30, 2015   Royal ... introduced ScanWise Implant, the industry,s first MRI guided user ... the scanning of patients with MR Conditional implants, such ... at the 2015 Radiological Society of North America ... streamline exams and supports diagnostic confidence of this growing ...
Breaking Medicine Technology: