Navigation Links
Gut Bacteria May Be Key to Gastric Bypass' Effects: Study
Date:3/27/2013

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, March 27 (HealthDay News) -- Gastric bypass surgery may help people lose weight by changing the makeup of bacteria living in the intestines, suggests a new study conducted in mice.

Scientists from Harvard University and Massachusetts General Hospital in Boston discovered that performing gastric bypass surgery on mice altered the composition of the bacterial colony living in the animals' guts. Even when they did not perform the surgery, and just transferred the new bacterial colony into the intestines of mice, those mice lost weight.

"Simply by colonizing mice with the altered microbial community, the mice were able to maintain a lower body fat, and lose weight -- about 20 percent as much as they would if they underwent surgery," senior study author Peter Turnbaugh, a Bauer Fellow at Harvard's Faculty of Arts and Sciences Center for Systems Biology, said in a statement.

Turnbaugh's research partner said the implications of the finding might one day be far-reaching.

"Our study suggests that the specific effects of gastric bypass on the microbiota contribute to its ability to cause weight loss, and that finding ways to manipulate microbial populations to mimic those effects could become a valuable new tool to address obesity," senior study author Lee Kaplan, director of the Obesity, Metabolism and Nutrition Institute at Massachusetts General, said in a statement.

"The ability to achieve even some of these effects without surgery would give us an entirely new way to treat the critical problem of obesity, one that could help patients unable or unwilling to have surgery," Kaplan added.

Another expert agreed that the gut is intricately tied to weight loss.

"The gut is a key player in metabolism, and this makes it even more than ever an ideal target for interventions for treating metabolic diseases and obesity," said Dr. Francesco Rubino, a researcher and metabolic surgeon with the Catholic University of Rome, in Italy.

It may someday be possible to use medication or changes in diet to help people lose weight by changing the makeup of germs in the intestine, he said. "We might be doing that with other methods once we understand how the bypass does it."

At issue are the millions, if not trillions, of germs that live in your digestive system, Rubino said.

"For many years, we thought they were a contaminant because we get them from the environment as we eat," he said. But, scientists now understand that the bacteria play a role in the way the body processes food. "We eat for us, but we also eat for them [bacteria]," he explained.

Scientists have suspected that gastric bypass procedures, which funnel food away from the stomach, change the makeup of bacteria in the gut, he said.

Why might gastric bypass have this effect? It appears to be more than simply a matter of the intestinal germs changing because a mouse is eating less, Rubino said. The bypass, by shortening the digestive tract, may actually change "the chemistry of the intestinal environment where these bugs live."

Scientists note that research with animals often fails to provide similar results in humans.

Jeffrey Cirillo, a professor with the department of microbial and molecular pathogenesis at Texas A&M Health Science Center, praised the study but pointed out that one part -- the transfer of germs from one mouse to another -- will be a challenge in humans.

"The transfers were done to germ-free animals, but humans are not germ-free, and it will be difficult to take a pill and get germs to the right location [in the digestive system]," Cirillo said.

The study appears in the March 27 issue of Science Translational Medicine.

More information

For more about gastric bypass surgery, try the U.S. National Library of Medicine.

SOURCES: Francesco Rubino, M.D., researcher and metabolic surgeon, Catholic University of Rome, Italy; Jeffrey Cirillo, Ph.D., professor, department of microbial and molecular pathogenesis, Texas A&M Health Science Center, College of Medicine, Bryan, Texas; March 27, 2013, Science Translational Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Certain bacteria suppress production of toxic shock toxin: Probiotic potential looms
2. Some bacteria may protect against disease caused by stomach infection
3. Nightmare Bacteria Spreading in U.S. Hospitals, Nursing Homes: CDC
4. Bacterial Vaginosis Treatment
5. How “BV Miracle” Helps Women Cure Bacterial Vaginosis Permanently – Health Reviews
6. With Acne, Bacteria Strain on Your Skin May Be Culprit
7. UV-Aid New Technology Utilizes Hydroxyls to Eliminate Bacteria and Viruses Helping Prevent Colds, Flu, and Ear Infections
8. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
9. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
10. Study identifies factors associated with eradication of bacteria linked to gastric cancer
11. C-Section, Formula May Disrupt Good Gut Bacteria in Babies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gut Bacteria May Be Key to Gastric Bypass' Effects: Study
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: