Navigation Links
Gut Bacteria Fights Inflammatory Bowel Disease
Date:5/28/2008

Mouse study finds molecule boosted cells eliminating colitis, Crohn's symptoms

WEDNESDAY, May 28 (HealthDay News) -- A molecule produced by intestinal bacteria can eliminate symptoms of inflammatory bowel disease (IBD) in mice, U.S. researchers say.

IBD includes Crohn's disease and ulcerative colitis.

It has long been known that the guts of humans and other mammals contain about 1,000 different species of bacteria that protect against infection and aid digestion. It has also been suspected that recent increases in asthma and certain food allergies may be due to disruptions in the delicate balance of the intestinal ecosystem, according to background information in the study.

Previous research has found that the sugar molecule polysaccharide A (PSA), which is produced by a species of intestinal bacteria called Bacteroides fragilis, boosted levels of immune system cells known to protect against colitis and Crohn's.

In this new study, researchers at Harvard Medical School, Brigham and Women's Hospital, and the California Institute of Technology infected immune-suppressed mice with a harmful bacteria called Helicobacter hepaticus. The mice quickly developed IBD.

But when B. fragilis was combined with H. hepaticus, the mice remained healthy. Further tests revealed that PSA produced by B. fragilis was a key factor in preventing IBD. The molecule does this by prompting immune cells to secrete an anti-inflammatory interleukin called IL-10, which suppresses the inflammation caused by IBD.

This is the first time a beneficial molecule produced by intestinal bacteria has been shown to be therapeutic in an animal model. The study is published in the May 29 issue of Nature.

The researchers said their finding demonstrates the potential for "good" bacteria to benefit human health.

"Given the sheer number of bacteria in the gut, the potential for discovering new molecules that can treat a whole range of these diseases is promising," study co-author Dennis Kasper, a professor of medicine and microbiology and molecular genetics at Harvard Medical School, and director of the Channing Laboratory at Brigham and Women's Hospital, said in a prepared statement.

More information

The Canadian Society of Intestinal Research has more about IBD.



-- Robert Preidt



SOURCE: Harvard Medical School, news release, May 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Vancouver researchers discover missing link between TB bacteria and humans
2. Bioniche Updates re: Mycobacterial Cell Wall Technology Platform
3. Electrolyzed Water Gives Boost to Eliminating Food-Borne Bacteria Such as Salmonella, E. coli and Listeria Murrays Chicken to be First Poultry Processor to Utilize New Technology in its Food Sanitation Process
4. Lung transplants in cystic fibrosis patients with life-threatening bacteria sparks debate at ISHLT
5. Mayo Clinic Proceedings examines link between bacteria in the digestive system and obesity
6. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
7. Do bacterial combinations result in enhanced cytokine production? No!
8. New chemical can kill latent tuberculosis bacteria
9. Bacteria Mix in Guts of Babies Predicts Obesity
10. New bacteria contaminate hairspray
11. Does Antibacterial Soap Work? At Least One Really Does.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: