Navigation Links
Gut Bacteria Fights Inflammatory Bowel Disease
Date:5/28/2008

Mouse study finds molecule boosted cells eliminating colitis, Crohn's symptoms

WEDNESDAY, May 28 (HealthDay News) -- A molecule produced by intestinal bacteria can eliminate symptoms of inflammatory bowel disease (IBD) in mice, U.S. researchers say.

IBD includes Crohn's disease and ulcerative colitis.

It has long been known that the guts of humans and other mammals contain about 1,000 different species of bacteria that protect against infection and aid digestion. It has also been suspected that recent increases in asthma and certain food allergies may be due to disruptions in the delicate balance of the intestinal ecosystem, according to background information in the study.

Previous research has found that the sugar molecule polysaccharide A (PSA), which is produced by a species of intestinal bacteria called Bacteroides fragilis, boosted levels of immune system cells known to protect against colitis and Crohn's.

In this new study, researchers at Harvard Medical School, Brigham and Women's Hospital, and the California Institute of Technology infected immune-suppressed mice with a harmful bacteria called Helicobacter hepaticus. The mice quickly developed IBD.

But when B. fragilis was combined with H. hepaticus, the mice remained healthy. Further tests revealed that PSA produced by B. fragilis was a key factor in preventing IBD. The molecule does this by prompting immune cells to secrete an anti-inflammatory interleukin called IL-10, which suppresses the inflammation caused by IBD.

This is the first time a beneficial molecule produced by intestinal bacteria has been shown to be therapeutic in an animal model. The study is published in the May 29 issue of Nature.

The researchers said their finding demonstrates the potential for "good" bacteria to benefit human health.

"Given the sheer number of bacteria in the gut, the potential for discovering new molecules that can treat a whole range of these diseases is promising," study co-author Dennis Kasper, a professor of medicine and microbiology and molecular genetics at Harvard Medical School, and director of the Channing Laboratory at Brigham and Women's Hospital, said in a prepared statement.

More information

The Canadian Society of Intestinal Research has more about IBD.



-- Robert Preidt



SOURCE: Harvard Medical School, news release, May 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Vancouver researchers discover missing link between TB bacteria and humans
2. Bioniche Updates re: Mycobacterial Cell Wall Technology Platform
3. Electrolyzed Water Gives Boost to Eliminating Food-Borne Bacteria Such as Salmonella, E. coli and Listeria Murrays Chicken to be First Poultry Processor to Utilize New Technology in its Food Sanitation Process
4. Lung transplants in cystic fibrosis patients with life-threatening bacteria sparks debate at ISHLT
5. Mayo Clinic Proceedings examines link between bacteria in the digestive system and obesity
6. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
7. Do bacterial combinations result in enhanced cytokine production? No!
8. New chemical can kill latent tuberculosis bacteria
9. Bacteria Mix in Guts of Babies Predicts Obesity
10. New bacteria contaminate hairspray
11. Does Antibacterial Soap Work? At Least One Really Does.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... Seattle, WA, and Washington, DC (PRWEB) , ... ... ... PATH and the Siemens Foundation today announced a new initiative—the Siemens ... technologies for low-resource settings. The partnership will recruit top students from U.S. ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , ... http://www.fdanews.com/cdrhenforcementtrends , As Winston Churchill said, “Those who don’t learn ... 2015 will show what to expect when they come knocking this year. But that takes ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical Therapy Association ... CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the country are ... action, learn more about their chosen field and network with their colleagues. As ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker ... Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and ... hydrated before the big event. The invitation-only gifting suite, held this year at the ...
(Date:2/12/2016)... Appleton, Wis. (PRWEB) , ... February 12, 2016 ... ... its second Lean Leadership Series at Zuckerberg San Francisco General Hospital on April ... to practice new behaviors and create new habits. The workshops cover a broad ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- The primary goal of this research is to ... usage of liquid biopsy. Key information the survey seeks ... of liquid biopsy adoption amidst future users - Predominantly ... - Sample inflow to conduct liquid biopsy tests - ... so on. - Correlation analysis of sample type and ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 ... and instruments commonly used in laboratories. These may range ... scale condensers. Laboratory glassware is made from borosilicate glass ... shock. Laboratory plasticware, on the other hand, started gaining ... that it was easier to replace glass with plastic ...
(Date:2/11/2016)... , Feb. 11, 2016  Governor Andrew M. ... will create 1,400 jobs throughout Western New ... partnership with the SUNY Polytechnic Institute, includes a major ... Building in Buffalo , as well ... manufacturing facility in Dunkirk . The ...
Breaking Medicine Technology: