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Gum Disease Might Boost Cancer Risk
Date:5/27/2008

Chronic inflammation could be the link, experts say

TUESDAY, May 27 (HealthDay News) -- There may be another good reason to floss each day: A new study finds that gum disease could raise the risk for cancer.

"Men with history of periodontal disease had a 14 percent higher risk of cancer than those who did not have periodontal disease, and the increase persisted among never smokers," said lead researcher Dominique Michaud, a cancer epidemiologist at Imperial College London, in the U.K.

People with gum infections do have an increased amount of inflammatory markers circulating in their blood, and inflammation has been linked to cancer, experts say. But the exact link, if any, between gum disease and cancer remains unclear.

This new finding needs to be examined in other populations and among women, but it at least suggests that oral health may have some impact on cancer risk, Michaud said.

"If other data can support this association, then it will have implications for prevention and may provide some new clues on the role of the immune function in cancer development," Michaud said.

The report is published in the June edition of the journal The Lancet Oncology.

In the study, Michaud's team collected data on more than 48,000 American men who participated in the Health Professionals Follow-Up study, which included health professionals aged 40 to 75.

During an average of 17.7 years of follow-up, 5,720 cancer cases were reported. These cases excluded non-melanoma skin cancer and non-aggressive prostate cancer. The most common cancers reported were colorectal, melanoma, lung and bladder and advanced prostate cancer, Michaud's group found.

After taking into account other risk factors, such as smoking and diet, the researchers found that men with a history of gum disease had a 14 percent higher risk of developing cancer compared with men did not have a history of
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