Navigation Links
Guardian of genome predicts treatment outcomes for childhood cancer
Date:11/5/2007

Researchers have identified a new role for a cancer-prevention gene in the response to drug treatment for childhood cancer.

In humans, the p53 tumour suppressor gene, also known as the guardian of the genome, is known for its role in the prevention of cancer. Mutations in the gene are associated with a high incidence of cancer due to the uncontrolled division of cells which give rise to tumours.

In childhood cancers such as neuroblastoma, p53 mutations are rare at diagnosis, however they can emerge after chemotherapy.

A recent study published in the international journal Cancer Research this month by researchers from the Childrens Cancer Institute Australia for Medical Research (CCIA), and collaborators in the USA, describes a new role for p53 in childhood cancer.

The group showed that by inactivating p53 in neuroblastoma cells, the most common childhood cancer, the cancer cells became resistant to a number of chemotherapy drugs.

Our results provide definitive evidence of a role for p53 as a gene which dictates drug sensitivity in neuroblastoma, said Dr Xue of CCIAs Molecular Diagnostics Program.

These results highlight the importance of p53 status as an indicator of a patients treatment response in neuroblastoma.

Further research has found that p53 does not have one defined function in cancer susceptibility to treatment, adds Dr Xue. In some cancer cell types it does not act as a drug sensitivity gene. It is therefore important to assess the clinical effect of p53 mutations in different cancers in a tissue context.


'/>"/>

Contact: Pearly Harumal
pharumal@ccia.org.au
61-299-625-663
Research Australia
Source:Eurekalert

Page: 1

Related medicine news :

1. Guardians Dental Network Experiences Double-Digit Growth
2. Guardian Introduces New Program to Help Employers Control Health Care Premiums
3. One Species Genome Found Within Another
4. Genome Area Linked to Rheumatoid Arthritis
5. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
6. Scientists Map Elephantiasis Parasites Genome
7. Scientists Map Intestinal Bugs Genome
8. Hopkins researchers release genome data on autism
9. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
10. Cats Genome Map Purrfected
11. Domestic cat genome sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Gym Source, ... of a new showroom at South Dixie Hwy in Miami, FL. , “We are ... Gym Source. “The new innovative in-store concept is designed to give clients a seamless ...
(Date:1/17/2017)... Los Angeles, CA (PRWEB) , ... January 17, ... ... conflicted and concerned by the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting ... tragedies and magical moments that help everyone endure and pass through tough times, ...
(Date:1/17/2017)... ... January 17, 2017 , ... Kevin Harrington (one of the original Sharks ... DRTV campaigns regarding the topic of Beauty and Personal Care. , ... What better way to commit to these changes than beginning with personal care and ...
(Date:1/17/2017)... ... January 17, 2017 , ... Achieve TMS West, with multiple ... new office in San Clemente, California this month. Achieve TMS West is the ... treating individuals struggling with major depression. Depression impacts over 15 million adults in ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples Health is pleased to ... on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more ... addition to our provider network, and the addition will benefit our members in ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Research and Markets has announced the addition of ... to their offering. ... The global fluoropolymer market in the healthcare industry to grow ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has been ... experts. The report covers the market landscape and its growth prospects ...
(Date:1/17/2017)... Tocagen Inc ., a clinical-stage, cancer-selective gene therapy company, today announced ... pharmaceutical development at Tocagen, will present at Phacilitate Cell & ... Miami . Details of the ... ... - what to do when and why Date and Time: Wednesday, ...
(Date:1/17/2017)... 2017 Research and Markets has announced the ... Generic), Manufacturer (Captive, Merchant), Synthesis (Synthetic, Biotech), Product (mAb, Hormone) Drug ... 2021" report to their offering. ... The global active pharmaceutical ingredients market is ... Billion in 2016, growing at a CAGR of 6.3% from 2016 ...
Breaking Medicine Technology: