Navigation Links
Guardian of genome predicts treatment outcomes for childhood cancer
Date:11/5/2007

Researchers have identified a new role for a cancer-prevention gene in the response to drug treatment for childhood cancer.

In humans, the p53 tumour suppressor gene, also known as the guardian of the genome, is known for its role in the prevention of cancer. Mutations in the gene are associated with a high incidence of cancer due to the uncontrolled division of cells which give rise to tumours.

In childhood cancers such as neuroblastoma, p53 mutations are rare at diagnosis, however they can emerge after chemotherapy.

A recent study published in the international journal Cancer Research this month by researchers from the Childrens Cancer Institute Australia for Medical Research (CCIA), and collaborators in the USA, describes a new role for p53 in childhood cancer.

The group showed that by inactivating p53 in neuroblastoma cells, the most common childhood cancer, the cancer cells became resistant to a number of chemotherapy drugs.

Our results provide definitive evidence of a role for p53 as a gene which dictates drug sensitivity in neuroblastoma, said Dr Xue of CCIAs Molecular Diagnostics Program.

These results highlight the importance of p53 status as an indicator of a patients treatment response in neuroblastoma.

Further research has found that p53 does not have one defined function in cancer susceptibility to treatment, adds Dr Xue. In some cancer cell types it does not act as a drug sensitivity gene. It is therefore important to assess the clinical effect of p53 mutations in different cancers in a tissue context.


'/>"/>

Contact: Pearly Harumal
pharumal@ccia.org.au
61-299-625-663
Research Australia
Source:Eurekalert

Page: 1

Related medicine news :

1. Guardians Dental Network Experiences Double-Digit Growth
2. Guardian Introduces New Program to Help Employers Control Health Care Premiums
3. One Species Genome Found Within Another
4. Genome Area Linked to Rheumatoid Arthritis
5. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
6. Scientists Map Elephantiasis Parasites Genome
7. Scientists Map Intestinal Bugs Genome
8. Hopkins researchers release genome data on autism
9. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
10. Cats Genome Map Purrfected
11. Domestic cat genome sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... , ... June 27, 2017 , ... Harbour , ... token assets on the Ethereum blockchain, has released their technical specifications . , ... there has been little systematic approach for determining which offerings will garner the greatest ...
(Date:6/27/2017)... Meadows, IL (PRWEB) , ... June 27, 2017 ... ... Society for Dermatologic Surgery Association’s SUNucate efforts, Louisiana became the sixth state ... at school. With Governor John Bel Edwards’ signature, Louisiana joins the states ...
(Date:6/27/2017)... ... ... Two residents from the Gardant-managed assisted living and memory care communities in South ... protect Medicaid funding. , The video, which was produced by the American Health Care ... Cathy Schwarz, a couple who is still able to see each other every day ...
(Date:6/27/2017)... ... 27, 2017 , ... Atmosera , a premier Microsoft ... Services . The trusted, transparent, and secure solution for the cloud enablement of ... Atmosera’s next generation services include integrated capabilities for public, private, and hybrid Azure ...
(Date:6/27/2017)... Rosemont, Ill. (PRWEB) , ... June 27, 2017 , ... ... & Conditioning Association (NBSCA) have named Javair Gillett of the Houston Rockets the NBSCA ... recipient of the award is decided by NBSCA members who vote to select the ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... -- Endo International plc (NASDAQ: ENDP ) announced today ... the Company in a fireside chat at Goldman Sachs, 38 ... 2017 at 10:40 a.m. PT / 1:40 p.m. ET. The ... Rancho Palos Verdes, CA. A live ... on the Company,s website at http://www.endo.com/investors/overview . Participants should ...
(Date:5/23/2017)... PLEASANTON, Calif. , May 23, 2017 /PRNewswire/ ... world,s most innovative medical devices for pressure ulcer ... at the American Association of Critical Care Nurses, ... Houston May 22-25. The Leaf Patient ... designed specifically for the hospital environment.  The system ...
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
Breaking Medicine Technology: