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Growth more stunted in lower-income youth with kidney disease
Date:11/21/2013

Even with more prescriptions for growth hormone, children and adolescents with chronic kidney disease were less likely to grow to normal height ranges if they came from lower-income families, according to research funded by the National Institutes of Health. Results from the Chronic Kidney Disease in Children (CKiD) Study are published in the December issue of the American Journal of Kidney Diseases and online today at http://www.ajkd.org.

The children with lower socio-economic status (SES) who had CKD were likely to be substantially shorter than children their age from all income levels who didn't have the disease. Also, among all children with CKD, those from lower-income families were likely to be shorter than those from higher-income families. All participants had health insurance, a pediatric nephrologist, a doctor who treats kidney diseases in children, and no other known cause of growth deficiency.

Unlike findings from studies in adults, kidney disease progressed at similar rates across all income groups in CKiD. This came as a surprise to investigators, who expected faster kidney function decline with lower SES, as is found in adult CKD. Disease progression was defined by a decline in estimated glomerular filtration rate a measure of kidney function.

CKiD, the largest study of children with CKD, is the first to study the effects of income on kidney disease progression and complications in this population. The current study examined growth failure, common in children with CKD, because the disease can interfere with the normal effect of a child's own growth hormone.

"Since these lower SES children received higher proportions of prescriptions for growth hormone, it's possible that these families are not filling all their prescriptions or are filling them but not sticking to their treatment regimen as closely as higher-income families are," said Dr. Marva Mox
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Contact: Bill Polglase
NIDDKMedia@mail.nih.gov
301-496-3583
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Source:Eurekalert

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