Navigation Links
Growth more stunted in lower-income youth with kidney disease

Even with more prescriptions for growth hormone, children and adolescents with chronic kidney disease were less likely to grow to normal height ranges if they came from lower-income families, according to research funded by the National Institutes of Health. Results from the Chronic Kidney Disease in Children (CKiD) Study are published in the December issue of the American Journal of Kidney Diseases and online today at

The children with lower socio-economic status (SES) who had CKD were likely to be substantially shorter than children their age from all income levels who didn't have the disease. Also, among all children with CKD, those from lower-income families were likely to be shorter than those from higher-income families. All participants had health insurance, a pediatric nephrologist, a doctor who treats kidney diseases in children, and no other known cause of growth deficiency.

Unlike findings from studies in adults, kidney disease progressed at similar rates across all income groups in CKiD. This came as a surprise to investigators, who expected faster kidney function decline with lower SES, as is found in adult CKD. Disease progression was defined by a decline in estimated glomerular filtration rate a measure of kidney function.

CKiD, the largest study of children with CKD, is the first to study the effects of income on kidney disease progression and complications in this population. The current study examined growth failure, common in children with CKD, because the disease can interfere with the normal effect of a child's own growth hormone.

"Since these lower SES children received higher proportions of prescriptions for growth hormone, it's possible that these families are not filling all their prescriptions or are filling them but not sticking to their treatment regimen as closely as higher-income families are," said Dr. Marva Moxey-Mims, a pediatric kidney specialist at the NIH's National Institute of Diabetes and Digestive and Kidney Diseases, the study's primary funder. "Although there also could be other issues like nutrition or household finances contributing to this difference, the main lesson is that we may need to learn how to help families better follow treatment plans for their children with CKD."

Dr. Susan Furth, the study's lead author and a researcher at The Children's Hospital of Philadelphia, agrees. "More aggressive intervention or other programs to help support what's happening outside the doctor's office could help. For example, more frequent contact with nurses and other medical staff could help children and families understand and follow prescribed treatments," she said.

Also, blood pressure control a factor associated with kidney disease progression improved across the groups, though children with lower SES took an average of 4.5 years to get their blood pressure down within the normal range, compared to two years for those with a higher income. However, the longer time period did not appear to result in more advanced CKD in children from low income families.

"Clearly, we need to find better ways to achieve good blood pressure control in all the children," said Furth. "Like the growth hormone question, blood pressure could be a matter of being able to afford or regularly take the medications prescribed, or genetics, or may involve factors like diet, interactions with other medications, or other exposures that could hinder the treatments from working as well for some children."

Moxey-Mims added that more research is proposed in CKiD to examine treatment adherence, and a partnership with the NIH-supported Chronic Renal Insufficiency Cohort Study (in adults) will look at associations between health literacy and SES. Health literacy is the capacity to understand basic health information to make appropriate health decisions.

SES was based on reported annual family income: $75,000 or higher (high), $30,000 to $75,000 (middle), and less than $30,000 (low). Low and middle household incomes were more often associated with minority ethnicity (African-American and Latino), compared to higher income 39 percent and 20 percent vs. 7 percent.

CKiD is a multicenter prospective study of children ages 1 to 16 years with mild to moderate impairment of kidney function. Forty-eight sites in the United States and two in Canada are following more than 600 children. Children's Mercy Hospital at the University of Missouri-Kansas City School of Medicine and The Children's Hospital of Philadelphia at the University of Pennsylvania are the study's clinical coordinating centers. The Johns Hopkins Bloomberg School of Public Health in Baltimore is the data coordinating center. The ongoing CKiD study aims to determine risk factors for declining kidney function and to understand how the decline affects cognitive function, behavior, growth failure and the risk for cardiovascular disease.


Contact: Bill Polglase
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Related medicine news :

1. Global Dental Equipment Market - Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019
2. PERFECT TEETH Continues Steady Growth Announces Opening of 67th State-of-the-Art Dental Office
3. Global Microscopy Devices Market - Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018
4. Helping Hands Gifts for Growth™ Grant Winners Announced by BIOTONE and BIOFREEZE
5. Idol Lash: The Clinically Proven Eyelash Growth Enhancer Now Available in the Market With 1 Extra Bottle Offer
6. Global mHealth Market - Mobile Health Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019
7. Workers’ Compensation Costs Per Claim Moderating In Pennsylvania After Years of Growth, New Study Reports
8. Global Pain Management Devices Market - Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018
9. Compression Therapy Market to 2019 - Growth due to Increased Awareness in Venous Disease Management Offset by Reimbursement Issues
10. Provillus - Natural Hair Regrowth Treatment Formula Now Available for Men and Women Now Offers 1 Extra Bottle on All Orders
11. BCC Research: PPACA, Demand in Emerging Markets Shape Growth in Healthcare for Foreseable Future
Post Your Comments:
(Date:11/24/2015)... ... ... Serenity Point Rehabilitation, a holistic treatment center for substance abuse located in ... staff members at their recovery center. The videos highlight some of the various aspects ... things that make their recovery program so unique. , “Making the decision to seek ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cold Shoulder , LLC launched their Pro Vest, the latest ... hit their goal of $20,000 in under 10 hours. , The campaign, ... PRO Weight Loss Vest to the market. , The PRO Vest provides consumers with a ...
(Date:11/24/2015)... ... ... Dr. Rodney E. Willey , has answered a new calling – to relieve snoring ... treatment for snoring and sleep apnea through oral appliance therapy. He is ... in the US, one of four in the Illinois area. , Dr. Willey’s ...
(Date:11/24/2015)... ... ... Bibliomotion is thrilled to announce the launch of UNCONVENTIONAL ... Nancy M. Schlichting, Chief Executive Officer of Henry Ford Health System (November ... of patients and their families, shaped my desire to improve the system of care. ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... products, announces Innovative Blending, a household invention that revolutionizes the vending machine industry ... Smoothie Bars market is worth $2 billion," says Scott Cooper, CEO and Creative ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... DELHI , November 25, 2015 ... invoked due to repeated failure of IVF cycles. After ... Bhatia was totally dejected and had lost all hopes that she would be ... first Indian miracle child conceived after failure of over ... to abroad (UK) before they decided to take one last attempt ...
(Date:11/24/2015)...  In the pharmaceutical industry, companies want to rapidly ... uncover new insights, tactics and strategies that will improve ... --> However, organizations often find it is difficult ... that all rules and regulations are met to ensure ... to efficiently launching market research projects is the conflicting ...
(Date:11/24/2015)... , November 24, 2015 --> ... report "Spine Biologics Market by Product Type (Bone Graft, Bine ... Discectomy and Fusion, Posterior Lumbar Interbody Fusion), End User, and ... global market was valued at $1.90 Billion in 2014 and ... CAGR of 4.4% during the forecast period of 2015 to ...
Breaking Medicine Technology: