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Growth in cerebral aneurysms increases risk of rupture
Date:7/1/2013

delines based on research conducted by the International Study of Unruptured Intracranial Aneurysms and other studies suggest that known aneurysms less than seven millimeters in size have a low risk of rupture and do not need to be monitored with imaging.

Compared to the aneurysms that stayed the same size, the 46 growing aneurysms in the study were associated with a 12-fold higher risk of rupture. The researchers calculated the risk of rupture for growing aneurysms at 2.4 percent per patient-year, versus 0.2 percent for aneurysms without growth.

"Our data support the need to perform longitudinal follow-up imaging to monitor for possible growth in all incidental unruptured aneurysms, including small lesions," Dr. Villablanca said.

The researchers also found that tobacco smoking and the initial size of the aneurysm were independent predictors of aneurysm growth. Together, these risk factors were associated with 78.4 percent of all aneurysm growth in the study.

"The positive association between aneurysm growth, aneurysm size, and cigarette smoking suggests that the combination of these factors are associated with an increased risk of rupture and may influence the need for therapeutic intervention," Dr. Villablanca said.

Observation was the treatment of choice for 194 of 212 (91 percent) stable aneurysms. When aneurysm growth was discovered by CTA imaging, 50 percent of the growing aneurysms were treated, while the remaining 50 percent continued to be observed.


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Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

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