Navigation Links
Growth hormone treatment for children may exacerbate feelings of depression
Date:6/23/2014

CHICAGO, IL Short, otherwise healthy children who are treated with growth hormone (GH) may become taller, but they may also become more depressed and withdrawn over time, compared to children the same age and height who are not treated with GH, a new study finds. The results were presented in a poster Monday, June 23 at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.

"Daily injections, frequent clinic visits and repeated discussions about height might exacerbate instead of improve psychosocial concerns in children with idiopathic short stature (ISS) who are otherwise healthy, and give them no cognitive improvements," said lead author Emily C. Walvoord, MD, associate professor of clinical pediatrics at the Indiana University School of Medicine in Indianapolis.

While the link between using GH to increase height and improved psychological adaptation is being debated, early data suggest that the subtle cognitive problems seen in adults with growth hormone deficiency (GHD) might also occur in children with GHD and might improve with treatment.

Dr. Walvoord and her colleagues evaluated the cognitive and behavioral status of children with GHD and ISS after they received either GH therapy or observation alone, and their preliminary results presented here challenge the idea that improvements in height also result in improvements in psychological functioning. Their findings also raise the concern that GH treatment of these otherwise healthy children might even worsen their emotional symptoms.

In their study, 41 children with GHD and ISS between the ages of 6 and 16 years of age, 11 on average, took a series of tests that examined their cognitive functioning, and their parents completed questionnaires that assessed their child's emotional and behavioral functioning.

The children were then assigned to either the group that was treated with growth hormone or the untreated control group, and after 9 to 12 months, the children in both groups were retested.

So far, 41 children have had initial testing and 28 have had follow up testing. Among these children, the researchers have found no differences in cognitive functioning between GHD and the ISS children from their first test to their retest.

However, compared with the untreated ISS children, whose depression and withdrawal according to their parents' questionnaire responses have lessened over that period, the depression and withdrawal symptoms in the treated GHD and ISS children have worsened.

"This novel study of the cognitive and emotional effects of GH therapy in children with GHD and ISS compared to untreated short children raises concerns that, despite improvements in height, these children may not achieve psychosocial benefits," Dr. Walvoord said.


'/>"/>

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Breakthrough drug-eluting patch stops scar growth and reduces scar tissues
2. Growth hormone defect may protect against diabetes, cancer in unique ecuador population
3. Finding the Achilles Heel of ovarian tumor growth
4. Shrub growth decreases as winter temperatures fluctuate up
5. Scientists slow brain tumor growth in mice
6. Revealed:Proteins role in preventing heart muscle growth leading to heart failure
7. Breastfeeding promotes the growth of beneficial bacteria in the gut
8. Willetts announces new Engineering Fellowships for Growth
9. Scientists discover a new way to enhance nerve growth following injury
10. Scientists find key steps linking dietary fats and colon cancer tumor growth
11. Scaffolding protein promotes growth and metastases of epithelial ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2016)... ... May 30, 2016 , ... ... Shaolin warrior 8-day-8 and 8-night special intensive summer training camp starts on June ... summer camp offers families and children a fun and unique experience with an ...
(Date:5/29/2016)... ... May 29, 2016 , ... Whole Health Supply is ... new KlipPro KP-240L clipper is available to the public. This is an unusual clipper ... wider than the average clipper. , Everything about this product is concentrated on ease ...
(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can ... drop a preset onto their media," said Christina Austin - CEO of Pixel Film ... can quickly and easily add stylish color grades to their footage. A LUT is ...
(Date:5/28/2016)... ... ... of the city where’s it’s easy to spot the neon lights of chains serving fast ... diners with a taste for real food. , On May 13, the Best ... urban casual restaurant focusing on dishes made by hand with wholesome, organic ingredients that are ...
(Date:5/27/2016)... ... 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield of ... 2016 honorees. The award recognizes businesswomen who excel in their fields and who ... the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and Theresa ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... May 26, 2016 Since its ... into an essential life science tool for conducting genetic ... BCC Research reveals in its new report that the ... phase, one powered by a range of new applications ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... dringenden Bedarf zur Steuerung ... N.V. (NASDAQ: QGEN ; Frankfurt Prime ... Entwicklungsvereinbarung mit Therawis Diagnostics GmbH zur Entwicklung und ... sein. Ein erstes Projekt wird die Entwicklung und ...
(Date:5/25/2016)... , May 25, 2016  According to Kalorama Information, ... billion in 2015.  Though these are challenging times ... opportunity for success for companies that remain optimistic ... of new growth prospects medical device companies spend ... and development (R&D) than do companies in other ...
Breaking Medicine Technology: