Navigation Links
Growth hormone analog may reduce risk of fatty liver disease in HIV-infected patients
Date:7/19/2014

In a preliminary study, HIV-infected patients with excess abdominal fat who received the growth hormone-releasing hormone analog tesamorelin for 6 months experienced modest reductions in liver fat, according to a study in the July 23/30 issue of JAMA, a theme issue on HIV/AIDS. Patients infected with HIV demonstrate a high prevalence of nonalcoholic fatty liver disease, estimated at 30 percent to 40 percent. The issue is being released early to coincide with the International AIDS Conference.

In human immunodeficiency virus (HIV) infection, abdominal fat accumulation is associated with ectopic (out of place) fat accumulation in the liver. Nonalcoholic fatty liver disease (NAFLD) may progress to end-stage liver disease and liver cancer. To date, there are no approved pharmacologic strategies to reduce liver fat. Tesamorelin specifically targets abdominal fat reduction but its effects on liver fat are unknown, according to background information in the article.

Takara L. Stanley, M.D., of Massachusetts General Hospital and Harvard Medical School, Boston, and colleagues randomly assigned 50 antiretroviral-treated HIV-infected men and women with abdominal fat accumulation to receive tesamorelin (n=28), or placebo (n=22), subcutaneously daily for 6 months.

The researchers found a modest but statistically significant decrease in liver fat with tesamorelin. Hepatic lipid to water percentage (a measure of liver fat), decreased in the tesamorelin group (median, -2.0 percent) compared with placebo (median, 0.9 percent). In addition, there was a significant reduction in abdominal fat: the average change was -9.9 percent with tesamorelin vs 6.6 percent with placebo.

"The decrease in liver fat in this study suggests that strategies to reduce visceral adiposity merit further investigation in HIV-infected patients with NAFLD, a condition for which there are no approved treatments. Importantly, NAFLD is associated with visceral adiposity and other metabolic abnormalities in HIV," the authors write.

"Further studies are needed to determine the clinical importance and long-term consequences of these findings."


'/>"/>

Contact: Cassandra Aviles
cmaviles@partners.org
617-724-6433
The JAMA Network Journals
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
2. Low oxygen levels could drive cancer growth
3. Report using private health claims data shows prices are driving health spending growth
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Disease that stunts infants growth traced to same gene that makes kids grow too fast
6. Scientists discover mechanism that promotes lung cancer growth and survival
7. Nerve growth factors elevated in pancreatic cancer model
8. Exercise Wont Affect Breast Milk, Babys Growth: Study
9. QTrade's New Facility Anticipates Dramatic Growth of Tea Industry
10. Rising Solar Engineering and Design Firm Enters 1.7 MW's in Connecticut ZREC Auction and Positions for Future Growth
11. Mahvrick Expands to Brazil, Russia, India, China to Support Existing Client Customer Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... The Kelahan Agency, a ... to residents of southern New Hampshire, is teaming up with the New Horizons ... and homelessness in the region. , New Horizons for New Hampshire provides a ...
(Date:6/27/2017)... ... , ... Dr. Richard Amato, a respected periodontist in Monroe, CT, ... Implant Center of Connecticut. As part of the renovation, the cutting-edge practice added two ... to improve patient comfort while making it possible for Dr. Amato to provide even ...
(Date:6/27/2017)... ... 2017 , ... East Los Angeles dentist, Ramin Assili DDS , comments ... happens to a woman during pregnancy can have profound effects on a developing fetus, ... on a baby’s long-term health. This study, which was performed at the University of ...
(Date:6/26/2017)... California (PRWEB) , ... June 26, 2017 , ... ... of Male Fertility & Sexual Medicine Specialists, in collaboration with the Fertility Center ... for male fertility care: PESA (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular ...
(Date:6/26/2017)... ... , ... LARKR™ , an innovative new smartphone app providing on-demand talk ... to join its online treatment platform. , Launching in just a few days, ... number of people in need nationwide, and to supplement their traditional practices. Joining this ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... Holdings, Inc. (NYSE: HRC), will host its fiscal third quarter ... 2017, beginning at 7:30 a.m. (CDT) / 8:30 a.m. (EDT). ... in the conference call, dial (877) 304-8969 (domestic) or (631) ... minutes prior to the start to allow time to connect. ... Webcast: A simultaneous webcast of the call will ...
(Date:6/16/2017)... 2017 Datascope Corp. is voluntarily performing a worldwide field correction ... electrical test failure code.     ... PART NUMBER ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  ... This field correction also applies ...
(Date:6/14/2017)... 2017  ivWatch LLC, a medical device company focused ... therapy, is pleased to announce it was the Bronze ... Supplies and Equipment at the 2017 Medical Design Excellence ... industry. The award was presented by Medical Device and ... in New York during MD&M ...
Breaking Medicine Technology: