Navigation Links
Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
Date:11/8/2010

Alexandria, Va., USA It is well known that oral infection progressively destroys periodontal tissues and is the leading cause of tooth loss in adults. A major goal of periodontal treatment is regeneration of the tissues lost to periodontitis. Unfortunately, most current therapies cannot predictably promote repair of tooth-supporting defects. A variety of regenerative approaches have been used clinically using bone grafts and guiding tissue membranes with limited success.

In an article titled "FGF-2 Stimulates Periodontal Regeneration: Results of a Multicenter Randomized Clinical Trial," which is published in the International and American Associations for Dental Research's Journal of Dental Research, M. Kitamura, from Osaka University Graduate School of Dentistry, Japan, and a team of researchers conducted a human clinical trial to determine the safety and effectiveness of fibroblast growth factor-2 (FGF-2) for clinical application. This is the largest study to date in the field of periodontal regenerative therapy.

A randomized, double-masked, placebo-controlled clinical trial was conducted in 253 adults afflicted with periodontitis. Periodontal surgery was performed, during which one of three different doses of FGF-2 was randomly administered to localized bone defects. Each dose of FGF-2 showed significant superiority over the standard of care (vehicle alone (p < 0.01)) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the mid-dose FGF-2 group. These results strongly support the topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

"This study represents the largest multi-center human clinical trial using growth factor therapy to repair tooth-supporting osseous defects," said JDR Editor-in-Chief William Giannobile. "The tissue engineering technology has important ramifications in the treating of localized bone defects around teeth resulting from periodontal disease."

The abstract is published in the Journal of Dental Research and is available online at http://bit.ly/jdr4616.

An accompanying editorial titled "Growth Factors and Periodontal Engineering: Where Next?" has been published. In it, author Martha Somerman, University of Washington, Seattle, states "for periodontal regeneration to continue as an attractive approach for restoring tissues lost to disease versus the choice for extraction and implant placement, we must focus our efforts on developing predictable therapies that include substantial restoration of tissues to physiological health with positive outcomes over the long term (e.g., greater than 10 years), as well as containing costs for our patients." To read this editorial, log in to the online JDR at http://bit.ly/jdr2203 or contact Ingrid L. Thomas at ithomas@iadr.org for a PDF of the article.


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Association for Dental Research
Source:Eurekalert

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Researchers create drug to keep tumor growth switched off
3. Firmex Achieves 237% Annual Revenue Growth Despite Tough M&A Environment in 2009
4. Kaiser Analysis Finds Record Medicaid Enrollment Growth in 2009
5. Media, small businesses invited to ACS Webinar on ways to take advantage of Chinas dynamic growth
6. Webmarketing 123 Profiled in National Study of High Growth Professional Services Firms
7. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
8. Bitter melon extract decreased breast cancer cell growth
9. A mothers sensitivity may help language growth in children with autism spectrum disorder
10. Chitosan as alternative to growth-promoting antibiotics for ruminants
11. Buy HGH Website Educates Consumers on the Pros and Cons of Human Growth Hormone Supplements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Interest is on the rise for ... as an orthogonal tool for RNAi hit validation. A key reason may be that ... rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. , Arrayed ...
(Date:5/31/2016)... ... 31, 2016 , ... In a recent interview on The Greenburgh Report radio ... NY-based WVOX (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed ... medical money maelstrom.” , During the interview with Mr. Feiner that aired on ...
(Date:5/31/2016)... ... May 31, 2016 , ... Advertising ... firm and statement solutions provider, for the tenth consecutive year as a Top ... of Advertising Age, and SourceLink ranked eighteenth in the “U.S. CRM/Direct Marketing Agency” ...
(Date:5/31/2016)... Port Washington, NY (PRWEB) , ... May 31, 2016 , ... ... and other essential nutrients to on the go individuals and dedicated athletes, continues to ... functions. , Loaded with whey, pea and milk protein, branched-chain amino acids (BCAA), ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... announced today the publication of an original infographic, " Health Benefits Reimbursement Compliance ... professionals understand how Zane Benefits complies with various federal regulations and reforms. , ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... PARIS , May 25,2016 ... with the near-infrared Cellvizio platform for urological and ... MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary ... important regulatory milestone in the US with the ... Food and Drug Administration (FDA). This new FDA ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May 25, 2016 ... ; Frankfurt Prime Standard: QIA) today announced that the company ... Diagnostics GmbH to develop and commercialize predictive assays in oncology. ... as a marker to predict effectiveness of anthracycline treatment in ... "We are pleased to partner with Therawis, which developed the ...
(Date:5/25/2016)... NEW YORK , May 25, 2016 ... Device Market Size, Share, Development, Growth and Demand Forecast ... Insulin Syringe, Insulin Pump and Others)" published by P&S ... valued at $9,998.3 million in 2015, and it is ... 2016-2022. Based on type, the insulin pump segment is ...
Breaking Medicine Technology: