Navigation Links
Growth factor protects key brain cells in Alzheimer's models
Date:2/8/2009

demonstration of the effectiveness and safety of BDNF administration in animals provides "a rationale for exploring clinical translation" to humans, the team concludes, suggesting that the protective and restorative effects of BDNF on damaged neurons and neuronal signaling may offer a new approach to treating Alzheimer's disease.

This work builds on previous studies by Tuszynski and others, demonstrating the therapeutic affects of nerve growth factor (NGF) administered to patients with Alzheimer's disease. In 2001, Tuszynski and his team at UC San Diego Medical Center performed the first surgical implants of NGF genes into the brains of Alzheimer's patients, with follow-up results showing these patients experienced a possible slowing in cognitive decline and increased metabolic function in the brain. The NGF studies continue today, with Phase 2, multi-center studies currently underway.

"NGF therapy aims to stimulate the function of specific cholinergic neurons, which are like the air traffic controllers of the brain, helping to direct the activities of cells in broad regions of the brain," Tuszynski explained. However, he added that the benefits of NGF therapy, if validated in ongoing trials, will not be curative. Eventually, the effect of the NGF "boost" will be countered by the widespread death of neurons in the cerebral cortex as a result of advancing Alzheimer's disease.

"In contrast, BDNF acts directly on dying cells in specific memory circuits of the brain," Tuszynski said. "In this series of studies, we have shown that BDNF targets the cortical cells themselves, preventing their death, stimulating their function, and improving learning and memory. Thus, BDNF treatment can potentially provide long-lasting protection by slowing, or even stopping disease progression in the cortical regions that receive treatment."

The protective and restorative effects of BDNF occurred independently of the build-up of amyloid, a protei
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Masimo to Present at the Roth Capital Partners 21st Annual OC Growth Stock Conference
2. CardioDynamics Reports Eighth Consecutive Quarterly Revenue Increase Over Prior Year and 12% Revenue Growth in 2008
3. Recession-Proof Your Career: High Job Growth Expected for Rehab Therapists
4. Hill-Rom Reports First Quarter Revenue Growth of 3.0 Percent to $352 Million and Earnings Per Fully Diluted Share From Continuing Operations of $0.23, an Increase of 15.0 Percent From the Prior Year
5. Align Technology Executives to Present at ROTH 21st Annual OC Growth Stock Conference
6. Cielo MedSolutions Announces Strong Revenue Growth in 2008
7. US Cancer Pain Market to Reach $5 Billion by 2018 - Cancer Patient Growth Drives Value
8. Shengtai Pharmaceutical to Present at Roth 21st Annual OC Growth Stock Conference
9. Growth hormone treatment after weight loss surgery prevents loss of muscle mass
10. New insights into growth factors role in brain development
11. Haemonetics Reports Double Digit Growth in Revenue, Operating Income, and EPS for the Third Quarter Fiscal 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Sterilizers manufacturers and is a valuable source of ... the industry. This report provides a basic overview of ... In this part, the report presents the company profile, ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... The short film “Color of Honor” by young director/producer ... true 9/11 hero, Welles Remy Crowther. It has been chosen ... of Nuremberg International Short Film Festival and the 8th International ... and director Luciana Lagana plays the mother of the ... Gregory Graham - Graham plays a heroic policeman ...
(Date:12/25/2014)... 2014 When head lice hits a home ... frenzy to get rid of it while keeping it from ... Gables now have the solution right in their neighborhood: ... Lice Troopers provides full spectrum head lice screening and treatment ... including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and ...
(Date:12/25/2014)... -- Overeating is common during the holidays, but there are ... says. "Don,t arrive at a party hungry. It may ... be attending a party, but deprivation leads to hunger, and ... Westchester Hospital in Mount Kisco, N.Y., said in a hospital ... day and even to have a snack before attending a ...
Breaking Medicine News(10 mins):Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Organisation (NACO), using better and an more improved data collection ... India are living with HIV. This clearly indicates that the ... ,Previously, in 2004 the figures complied had shown ... virus. It is estimated 38% of females and 57% male ...
... in the brain can explain why men and women ... the effects// of certain pain-relief drugs, reveals a new ... the Atlanta-based Center for Behavioral Neuroscience (CBN). ... the results highlight that similar differences occur in humans ...
... in local markets has paved for the establishment of ... chains in Hong Kong would be required to set ... to official sources. ,An operational pesticide ... Kong's food official that helped alleviate the citizens' anxiety ...
... online issue of BMC Public Health focuses on the co-relation ... and the incidence of prostate cancer (CaP).// This co-relation exists ... CaP. ,However by Dr. Leavy and colleagues did ... 2001 and 2002, 606 men with CaP from Western Australia ...
... a New Zealander says that he was forced to take dramatic ... received her medications. // He says the local DHB began trying ... take her from the hospital unless provided with the drug. ... one, which controls her nausea. The Hawke's Bay hospital refused to ...
... is one of the leading company which manufactures contact lens ... eye infections in some users. // After this ... Bausch & Lomb facilities. There was extensive microbiological testing conducted ... the culprit behind the eye infection. Bausch & Lomb stopped ...
Cached Medicine News:Health News:HIV/AIDS On The Rise In India 2Health News:Gender Difference In Pain Experience Explained By Brain Diversity 2
(Date:12/22/2014)... JUNCTION, N.J. , Dec. 22, 2014 /PRNewswire/ ... company marketing its CytoSorb® blood purification technology to ... surgery patients in 28 countries worldwide, today announced ... Russo , MD, FACS, as its Senior Vice ... Dr. Di Russo ...
(Date:12/22/2014)... --  TRU-D SmartUVC LLC, producers of the first ... that the General Services Administration has awarded the company ... This newly formed agreement will allow TRU-D SmartUVC ... including Department of Veteran Affairs and Department of Defense ... solutions for the Ebola effort in West ...
(Date:12/22/2014)... CHESTERBROOK, Pa. and STOCKHOLM ... AB (publ) (Sobi) and partner Auxilium Pharmaceuticals, Inc. today ... Use (CHMP) of the European Medicines Agency (EMA) has ... (collagenase clostridium histolyticum) for the treatment of adult men ... deformity of at least 30 degrees at the start ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... July 12, 2011 Roche (SIX: RO, ROG; ... CALP ) today announced a co-marketing ... protocols for the NimbleGen SeqCap EZ Library solution-based ... collaboration aims to simplify high throughput targeted resequencing ...
... 12, 2011 Millennium Pharmacy Systems, the leader in ... assisted living care settings, has announced a new release ... improved speed and usability as a motive, this release ... (electronic medication order entry). Enhancements to the system were ...
Cached Medicine Technology:Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 2Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 3Now Faster & Easier — Millennium Pharmacy Systems Announces New Release of MPSRx® 2
... tension-free sling technology marries with ... collagen matrix sling, for exceptional ... between sling and host, reduces ... vaginal abrasion or erosion and ...
... are designed specifically for rehabilitation facilities. These ... deck that provides the ideal cushioning for ... user-friendly control panel displays all pertinent information ... features a "soft start" the belt ...
... The FineTech-Brindley (also known as the VOCARE) ... has been used by people with spinal ... urinate) on demand. A secondary use of ... evacuation and promote penile erection.,The Bladder System ...
Used for dilation of a tract to the kidney for removal of stones. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: