Navigation Links
Growth factor TGF-B helps maintain health of retinal blood vessels
Date:4/7/2009

Scientists at Schepens Eye Research Institute have found that the growth factor known as TGF-β is essential to the health of blood vessels in the retina and that blocking it can cause retinal dysfunction. These findings, published in the April 2 issue of PLoS ONE, may have an important impact on the prevention and treatment of diseases such as diabetic retinopathy and macular degeneration.

"These results are significant because they add to our understanding of the molecules that help to maintain blood vessels in a healthy state," says Patricia D'Amore, PhD, senior scientist at Schepens and principal investigator of the study, who adds that this information may be useful in understanding the changes that occur in the retinal microvasculature prior to the development of proliferative diabetic retinopathy.

"Insight into the role of this growth factor may also help clinicians monitor the use of systemic drugs targeting TGF-β, which is elevated in a number of conditions (such as cancer and fibrotic diseases) to limit any vision problems that might occur as a side effects." adds Tony Walshe, PhD, the first author of the study and a Postdoctoral Fellow in the D'Amore's laboratory team.

Capillaries are the smallest blood vessels in the body and the site at which oxygen and nutrients are transferred from the blood to the tissues. A capillary is composed of an endothelial cell, which forms the lining of the small tube, and a pericyte, which wraps around the outside of the tube. Scientists have long believed that communication between these two cell types is necessary to maintain blood vessel structure and function.

According to Walshe, the goal of the PLoS ONE study was to determine if TGF-β plays a role in keeping blood vessels functioning normally. In previous experiments using tissue cultures, the D'Amore laboratory had identified TGF-β as a protein that results from the communication between the two cell types and which they use to maintain the health of the small blood vessels. In the current study, the team wanted to confirm that finding in animals.

To do that, they injected mice with a virus that produces large quantities of soluble endoglin, a protein that would circulate, and then bind to and inhibit TGF-β. When they examined the retinas of treated mice, the team found clear evidence that retinal blood vessels were losing their integrity-blood was not moving efficiently through the smaller vessels into the retina tissue, and fluid was leaking out of the vessels, which does not happen when the vessels are functioning properly. These defects led to the death of ganglion cells (nerve cells in the innermost part of the retina) and a loss of visual function.

According to D'Amore and Walshe, the demonstration of the role played by TGF-β is one more piece of a very complex set of controls that keeps blood vessels and the retina healthy.

Future studies are aimed at exploring what other molecules are involved in maintaining healthy blood vessels and how these relate to the development of microvascular diseases.


'/>"/>

Contact: Patti Jacobs
pjacobs12@comcast.net
617-864-2712
Schepens Eye Research Institute
Source:Eurekalert

Related medicine news :

1. Highlights of Economic and Business Growth in the Tampa Bay Region (News Briefs)
2. From Early Brain Development to Digestive Health, New Juicy Juice Beverages Aid Children Through Different Stages of Growth and Development
3. Kenyan Pharmaceutical Industry Can Expect Significant Growth Despite Global Conditions, Finds Frost & Sullivan
4. Cancer stem cells generated by cancer outgrowth
5. Varian Medical Systems to Celebrate Tenth Anniversary and Decade of Growth
6. Veterinary Specialist's Business Growth A Bright Spot in Dull Economy
7. Gerresheimer Achieves Solid Growth in Core Markets - Outlook Confirmed
8. CitiusTech Launches Vantage 2012 Program to Enable Healthcare ISVs to Meet CCHIT Requirements & Capture HITECH Act Related Growth Opportunities
9. Blood protein may hold key to stopping tumor growth in cancer patients
10. Organic Left Standing as the Gold Standard for Consumers Looking to Avoid Food Produced With Synthetic Growth Hormones
11. Coalition of Business, Labor, Academia and Bioscience Groups to Promote Medical Innovation, Spark Economic Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... TEXAS (PRWEB) , ... January ... ... Texas-based healthcare and clinical research networking-technology company founded by patient survivors, today ... innovative BlueCloud® business model, networking technologies and patient-inspired initiatives. , Like ...
(Date:1/24/2017)... ... 23, 2017 , ... United Nations Foundation President and CEO ... City Policy, also known as the Global Gag Rule, last enacted in 2001. ... non-governmental organizations from receiving any U.S. foreign assistance for family planning if they ...
(Date:1/24/2017)... , ... January 23, 2017 , ... ... of a new plugin that allows sleep centers to automatically connect and initialize ... (SDI)—is a thin client browser plugin is quickly installed on first use and ...
(Date:1/23/2017)... ... January 23, 2017 , ... Ultimate Medical ... Education Summit to be held March 23-25, 2017 in Tampa, and reminded educators ... , The keynote speakers include Dr. Michelle R. Weise, executive director of the ...
(Date:1/23/2017)... Grants Pass, OR (PRWEB) , ... January 23, 2017 , ... ... disease, took to the air to educate listeners about the benefits of making new ... in the U.S.,” Kleyne said, “it’s appropriate that we expect water infrastructure to become ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan. 23, 2017  Allergan plc, (NYSE: ... continued support of the International Headache Academy (IHA). Designed to ... and research scientists, IHA offers a three-day, intensive overview on ... Allergan has been the sole sponsor since the inception of ... and iHEAD in Europe in 2014. ...
(Date:1/23/2017)... 23, 2017 Ahead of today,s trading session, ... they have fared at the close: Kite Pharma Inc. (NASDAQ: ... OVAS ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... relative laggards on Friday, January 20 th , 2017, down on ... reports on these stocks now at: ...
(Date:1/23/2017)... SAN DIEGO , 23 janvier 2017  ResMed ... Winter Haven , Floride) ont annoncé aujourd,hui qu,ils se ... les litiges existants entre les parties. BMC et 3B ... de paiements de droits à ResMed, et ResMed effectuera ... à 3B pour clore le litige de Floride entre ...
Breaking Medicine Technology: