Navigation Links
Growth defects in cystic fibrosis may start before birth

A new study using a pig model of cystic fibrosis (CF) suggests that low levels of a growth promoting hormone at or before birth may contribute to growth defects in patients with CF.

The study, led by University of Iowa researchers and published online the week of Nov. 8 in the Early Edition of the Proceedings of the National Academy of Sciences, could help predict the severity of the disease in patients and may lead to new therapies for growth defects in people with CF.

Growth defects are common in people with CF and have been blamed, in part, on low levels of the growth-promoting hormone called insulin-like growth factor 1 (IGF1). Traditionally, the malnutrition and lung inflammation that accompany CF have been blamed for the decreased levels of IGF1. However, even patients who are relatively healthy often do not reach their full growth potential, and newborns with CF often are smaller at birth than healthy babies.

To investigate the relationship between neonatal IGF1 levels and growth patterns in CF, the research team studied newborn pigs with a CF-causing gene mutation. This animal model, which was generated by the UI researchers and colleagues at the University of Missouri in 2008, has many of the same symptoms and complications that are seen in humans with CF.

"By examining IGF1 at this time point, we eliminated consequences of lung inflammation, which is absent at birth, and malnutrition, because nutrition in utero is provided by the mother," explained Leah Reznikov, Ph.D., UI postdoctoral fellow in internal medicine and co-first author of the study. "We found that IGF1 levels were significantly reduced at birth in CF newborn pigs."

In addition, the UI researchers found that newborn CF pigs had shorter, smaller bones than pigs without CF suggesting that decreased IGF1 levels are associated with the growth defects, and that IGF1 levels may be reduced even before the pigs are born.

These findings led Reznikov and colleagues, including co-first author Mark Rogan, M.D., a former UI postdoctoral fellow in internal medicine, to examine levels of IGF1 in newborn humans with CF.

By testing blood samples collected through the Iowa Neonatal Metabolic Screening Program and the Iowa Department of Public Health, the researchers found that infants with CF have reduced IGF1 levels compared to healthy infants.

"Collectively, these findings suggest that IGF1 deficits begin very early in the course of CF disease and reductions in IGF1 may, in part, explain growth defects observed at birth in infants with CF," Reznikov said. "The findings also imply that IGF1 may serve as a potential biomarker of the disease and may be useful in prognostication, care and treatment of people with CF."

Patients with CF currently receive replacement pancreatic enzymes and insulin supplementation to counteract effects of CF. One possibility raised by the new findings is that IGF1 supplementation, beginning in infancy, might also be beneficial for growth in patients with CF. However, Reznikov cautioned that more testing is needed before this approach could be tested in humans.

"We would like to increase the sample size in our human studies and examine other parameters to better understand the relationship among CF, IGF1 and growth defects," she said."

If these test results are positive, Reznikov noted that the CF pigs would provide an excellent preclinical system to test whether IGF1 supplementation would be beneficial early in CF.


Contact: Jennifer Brown
University of Iowa - Health Science

Related medicine news :

1. Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
2. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
3. Estrogen replacement therapy speeds ovarian cancer growth, new study reports
4. Protein key to growth of pancreatic cancer
5. Individual mutations are very slow to promote tumor growth
6. New driver of T cell leukemia growth
7. Selective inhibition of BMK1 suppresses tumor growth
8. Journal of Vascular and Interventional Radiology sees growth, promise of tumor ablation
9. Nicotine binding to receptor linked to breast cancer cell growth
10. UCSD scientists find gas pedal -- and brake -- for uncontrolled cell growth
11. Brookhaven Lab and BioSET Inc. patent improved growth factor technology
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... According to ... a recent study has shown that women who successfully lose weight with a bariatric ... the United States each year. The article notes that anywhere from 40 to 50 ...
(Date:10/13/2015)... ... 13, 2015 , ... Symposium Chairman, Dr. Rod J. Rohrich is pleased to ... be held March 2nd and 3rd, 2016. The annual meeting, along with the ... physicians from around the world. , Key topics at this year's event will include ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... unique private messaging application, announced today a significant contract that will provide its ... Independence plans to build on the growing success of its Relay program, IBX ...
(Date:10/13/2015)... ... October 13, 2015 , ... NavaFit Inc. today announced the launch of ... train with, participate in local fitness & sporting events, and stay motivated. ... high medical costs drive us to get more serious about fitness and wellness, individuals ...
(Date:10/13/2015)... MA (PRWEB) , ... October 13, 2015 , ... Protein ... of the body, including muscle, bone, and blood. But how much protein does the ... complicated than it might seem, according to the October 2015 issue of Harvard ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  A minimally-invasive treatment just became available to men ... more than 10 years of clinical trials, the Food ... of High Intensity Focused Ultrasound (HIFU), a procedure that ... tissue and minimizing chances for erectile and urinary dysfunction ... a pioneering Miami urologist who ...
(Date:10/13/2015)... ALEXANDRIA, Va. , Oct. 13, 2015 /PRNewswire-USNewswire/ ... Pharmacists Association,s (NCPA) Digest , sponsored by ... to prescription medication and more diversified pharmacy revenue ... independent community pharmacies. NCPA Digest ... to patients and particularly those in underserved inner ...
(Date:10/13/2015)... , Oct. 13, 2015  Human Longevity, Inc. ... practice of medicine, announced today the launch of the ... project that has the potential to transform healthcare. The ... Diego, CA , at HLI,s headquarters facility. More ... in other US and International cities. ...
Breaking Medicine Technology: