Navigation Links
Growth defects in cystic fibrosis may start before birth
Date:11/9/2010

A new study using a pig model of cystic fibrosis (CF) suggests that low levels of a growth promoting hormone at or before birth may contribute to growth defects in patients with CF.

The study, led by University of Iowa researchers and published online the week of Nov. 8 in the Early Edition of the Proceedings of the National Academy of Sciences, could help predict the severity of the disease in patients and may lead to new therapies for growth defects in people with CF.

Growth defects are common in people with CF and have been blamed, in part, on low levels of the growth-promoting hormone called insulin-like growth factor 1 (IGF1). Traditionally, the malnutrition and lung inflammation that accompany CF have been blamed for the decreased levels of IGF1. However, even patients who are relatively healthy often do not reach their full growth potential, and newborns with CF often are smaller at birth than healthy babies.

To investigate the relationship between neonatal IGF1 levels and growth patterns in CF, the research team studied newborn pigs with a CF-causing gene mutation. This animal model, which was generated by the UI researchers and colleagues at the University of Missouri in 2008, has many of the same symptoms and complications that are seen in humans with CF.

"By examining IGF1 at this time point, we eliminated consequences of lung inflammation, which is absent at birth, and malnutrition, because nutrition in utero is provided by the mother," explained Leah Reznikov, Ph.D., UI postdoctoral fellow in internal medicine and co-first author of the study. "We found that IGF1 levels were significantly reduced at birth in CF newborn pigs."

In addition, the UI researchers found that newborn CF pigs had shorter, smaller bones than pigs without CF suggesting that decreased IGF1 levels are associated with the growth defects, and that IGF1 levels may be reduced even before the pigs are born.

These findi
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa - Health Science
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
2. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
3. Estrogen replacement therapy speeds ovarian cancer growth, new study reports
4. Protein key to growth of pancreatic cancer
5. Individual mutations are very slow to promote tumor growth
6. New driver of T cell leukemia growth
7. Selective inhibition of BMK1 suppresses tumor growth
8. Journal of Vascular and Interventional Radiology sees growth, promise of tumor ablation
9. Nicotine binding to receptor linked to breast cancer cell growth
10. UCSD scientists find gas pedal -- and brake -- for uncontrolled cell growth
11. Brookhaven Lab and BioSET Inc. patent improved growth factor technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... released a new blog post presenting the basic features of ... an accidental death and dismemberment rider for a car insurance ... benefits if the insured dies in an accident. Accidental death ... insurance. , AD&D is not expensive and can be ...
(Date:1/22/2015)... NY (PRWEB) January 22, 2015 ... of Sports Medicine flagship journal Medicine & Science ... L-Citrulline before exercise may help reduce gastrointestinal (GI) ... 1 , Participants in the double-blind, placebo-controlled ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne ... highest annual revenues in the past three years. Today, the ... dresses. , According to the sales manager of the company, ... them in 2015. This point can be reflected on the ...
(Date:1/22/2015)... January 22, 2015 Four years since the release ... which coincided with the marriage of Avasa & Matthew Love – ... which is scheduled for release through White Swan Records on February ... there is a sacred path available to all of us to ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... Corporation and its former outpatient therapy division,Physiotherapy ... United States $16.6,million to settle allegations that ... federal health care programs, the Justice Department,announced ... Physiotherapy, which is based,in Memphis, Tenn., submitted ...
... season certainly comes,with its share of holiday stress. But ... son or daughter. Here,s more on the difficult challenges,of ... has diabetes. Listen to this report from Abbott ... Registered journalists can access video, audio, text, graphics and,photos ...
... Medication Errors, WASHINGTON, Nov. 14 /PRNewswire-USNewswire/-- ... that the proposed standards for,electronic prescribing (e-prescribing) ... Services (CMS) confirm that the time is ... four years of extensive review by physicians, ...
... Teriparatide may help asthma patients avoid fracture, researchers ... A new drug has proven superior to standard ... treatment, researchers say. , Glucocorticoid medicines such as ... disorders, skin allergies and other conditions, researchers note. ...
... -- Ready, aim . . . , ... is introducing a high performance bullet based on technology ... promises more precision and superior terminal ballistics and is ... WolfTech of Wakeman, Ohio, the technology is first being ...
... Inc. (Nasdaq:,BIOD) today announced that Gerard Michel has ... President of Corporate Development,and Treasurer, effective November 20, ... to our team," said Dr. Solomon,Steiner, CEO and ... transactions and negotiating marketing partnerships and,other collaboration arrangements, ...
Cached Medicine News:Health News:Stryker Corp. & Physiotherapy Associates to Pay U.S. $16.6 Million for Alleged False Claims to Federal Health Care Programs 2Health News:PCMA: CMS Releases Proposed E-Prescribing Standards in Medicare 2Health News:New Drug Fights Medication-Linked Bone Loss 2Health News:Story tips from the Department of Energy's Oak Ridge National Laboratory, Nov. 2007 2Health News:Biodel Inc. Announces Appointment of Gerard Michel as CFO, VP of Corporate Development and Treasurer 2Health News:Biodel Inc. Announces Appointment of Gerard Michel as CFO, VP of Corporate Development and Treasurer 3
(Date:1/22/2015)... Inc. (NASDAQ: UPI ), a medical device company ... treat voiding dysfunctions, today reported financial results for the ... Global revenue for the Company,s Urgent ®  PC Neuromodulation ... revenue record, as compared to $3.9 million in the ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... PARK, Calif. , Jan. 22, 2015 Increasing ... the continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research ... chose a single-source solution for their translation and localization ...
Breaking Medicine Technology:Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
Inquire...
EPS 3501 : 3500 V, 150 mA, 100 W maximum. Constant voltage, constant current, or constant power modes. Stores and recalls three protocols. Excellent for manual DNA sequencing and IEF applications....
... The digital 200 V/2000 mA PSE Power ... 1 volt and 10 mA increments. • It ... 2000® apparatus simultaneously at 55°C. Features: Direct ... voltage, current and time • Voltage, mA and ...
... PowerPac Universal power supply, 100-120 and 220-240 ... A, and 1-500 W. The two-line, 16-character ... and monitoring of run progress. Built-in infrared ... unit contains a built-in switch when using ...
Medicine Products: