Date:2/5/2013

rgement of the prostate. The "malignant" cells contained more cAMP-forming enzyme than the "benign" cells. In cell culture experiments, the researchers then genetically altered the cancer cells so that they hardly produced LAC. The modified cells almost completely stopped proliferating. The same effect was achieved when the scientists inhibited the enzyme LAC by administering drugs. The team also identified the signal paths involved. cAMP formed by LAC activates two proteins, which in turn control the MAP kinase pathway. This signalling cascade is known to control cell growth and division. "The results of this study shed new light on the regulation of cell division and tumour formation", says Yury Ladilov.

Potentially interesting for therapy

One way to treat prostate cancer is radiation therapy. Dr. Ladilov's team is currently testing on cell cultures how a combination of radiation and LAC inhibitors effects the growth of cancer cells. "Of course, we hope that one day it will be possible to use this knowledge for the treatment of patients", says Bochum's biologist. "But there's still a long way to go." It is conceivable that the use of LAC inhibitors could reduce the amount of radiation required. The LAC inhibitors previously used in cell culture cannot, however, be used on humans.

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Contact: Yury Ladilov yury.ladilov@rub.de 49-234-322-7639 Ruhr-University Bochum Source:Eurekalert

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