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Growth arrest in prostate cancer
Date:2/5/2013

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP. When the scientists inhibited the enzyme, the cancer cell proliferation was suppressed. The team led by Dr. Yury Ladilov from the Department of Clinical Pharmacology at the Ruhr-Universitt Bochum reported together with colleagues from the Department of Urology at the RUB and the Cornell University in New York in the "Journal of Biological Chemistry".

cAMP is generated at several locations in the cell

Cyclic AMP (cAMP) is a second messenger molecule that controls many processes ranging from cell growth to cell death. An enzyme located in the cell membrane, called adenylyl cyclase, produces the molecule. Generated at the cell membrane, cAMP affects, for example, ion channels or other enzymes which are anchored in the membrane. However, the messenger also influences intracellular processes in the nucleus or in the mitochondria, the powerhouses of the cell. The common view was that cAMP diffuses from the membrane through the cell liquid the cytosol to its destination. Recent studies, however, suggest that cAMP is not only produced at the cell membrane, but also in the cytosol by the enzyme soluble adenylyl cyclase (LAC). The function of LAC has so far barely been studied.

The enzyme LAC plays a role in cell division

In a previous study, the RUB-team from the Department of Clinical Pharmacology showed that LAC plays a role in programmed cell death. The scientists and their colleagues are now elucidating the function of the enzyme in proliferation of tumour cells. First, they examined tissue samples from patients. They compared the amount of LAC in cells of a malignant prostate tumour with the amount of LAC in cells taken from benign enla
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Contact: Yury Ladilov
yury.ladilov@rub.de
49-234-322-7639
Ruhr-University Bochum
Source:Eurekalert

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