Navigation Links
Growth arrest in prostate cancer

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP. When the scientists inhibited the enzyme, the cancer cell proliferation was suppressed. The team led by Dr. Yury Ladilov from the Department of Clinical Pharmacology at the Ruhr-Universitt Bochum reported together with colleagues from the Department of Urology at the RUB and the Cornell University in New York in the "Journal of Biological Chemistry".

cAMP is generated at several locations in the cell

Cyclic AMP (cAMP) is a second messenger molecule that controls many processes ranging from cell growth to cell death. An enzyme located in the cell membrane, called adenylyl cyclase, produces the molecule. Generated at the cell membrane, cAMP affects, for example, ion channels or other enzymes which are anchored in the membrane. However, the messenger also influences intracellular processes in the nucleus or in the mitochondria, the powerhouses of the cell. The common view was that cAMP diffuses from the membrane through the cell liquid the cytosol to its destination. Recent studies, however, suggest that cAMP is not only produced at the cell membrane, but also in the cytosol by the enzyme soluble adenylyl cyclase (LAC). The function of LAC has so far barely been studied.

The enzyme LAC plays a role in cell division

In a previous study, the RUB-team from the Department of Clinical Pharmacology showed that LAC plays a role in programmed cell death. The scientists and their colleagues are now elucidating the function of the enzyme in proliferation of tumour cells. First, they examined tissue samples from patients. They compared the amount of LAC in cells of a malignant prostate tumour with the amount of LAC in cells taken from benign enlargement of the prostate. The "malignant" cells contained more cAMP-forming enzyme than the "benign" cells. In cell culture experiments, the researchers then genetically altered the cancer cells so that they hardly produced LAC. The modified cells almost completely stopped proliferating. The same effect was achieved when the scientists inhibited the enzyme LAC by administering drugs. The team also identified the signal paths involved. cAMP formed by LAC activates two proteins, which in turn control the MAP kinase pathway. This signalling cascade is known to control cell growth and division. "The results of this study shed new light on the regulation of cell division and tumour formation", says Yury Ladilov.

Potentially interesting for therapy

One way to treat prostate cancer is radiation therapy. Dr. Ladilov's team is currently testing on cell cultures how a combination of radiation and LAC inhibitors effects the growth of cancer cells. "Of course, we hope that one day it will be possible to use this knowledge for the treatment of patients", says Bochum's biologist. "But there's still a long way to go." It is conceivable that the use of LAC inhibitors could reduce the amount of radiation required. The LAC inhibitors previously used in cell culture cannot, however, be used on humans.


Contact: Yury Ladilov
Ruhr-University Bochum

Related medicine news :

1. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
2. Low oxygen levels could drive cancer growth
3. Report using private health claims data shows prices are driving health spending growth
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Disease that stunts infants growth traced to same gene that makes kids grow too fast
6. Scientists discover mechanism that promotes lung cancer growth and survival
7. Nerve growth factors elevated in pancreatic cancer model
8. Exercise Wont Affect Breast Milk, Babys Growth: Study
9. QTrade's New Facility Anticipates Dramatic Growth of Tea Industry
10. Rising Solar Engineering and Design Firm Enters 1.7 MW's in Connecticut ZREC Auction and Positions for Future Growth
11. Mahvrick Expands to Brazil, Russia, India, China to Support Existing Client Customer Growth
Post Your Comments:
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST ... the most savings. , With possible savings of up to 20% off orders $80 or ... homepage of the website every few hours. , As a competitive e-commerce website for skin ...
(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major question facing ... last year? , This question has not been an easy question to answer. Especially ... age and the younger workforce don’t share the same discipline around working long hours. ...
(Date:11/27/2015)... , ... November 27, 2015 , ... According to an ... by the University of Toronto and the University of British Columbia suggested that laws ... head injuries. The article explains that part of the reason for the controversial conclusion ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the health care in America. As people age, more care is needed, especially ... are rising, and medical professionals are being overworked. The forgotten part of this ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from ... dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , ... prescription medications. In doing so, it could help to prevent potential overdose situations. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , 26 november 2015 AAIPharma ... de geplande investering aan van ten minste ... laboratoria en het mondiale hoofdkantoor in ... zal resulteren in extra kantoorruimte en extra ... de groeiende behoeften van de farmaceutische en ...
(Date:11/26/2015)... November 26, 2015 ... nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische therapie ... ) --> ... (Photo: ) ... Medisch Centrum (LUMC) blijkt ...
(Date:11/26/2015)... 2015 Research and Markets ( ) has ... Market Outlook to 2019 - Rise in Cardiac Disorders and ... report to their offering. Boston ... scientific and others. --> The ... Boston scientific and others. ...
Breaking Medicine Technology: