Navigation Links
Growth arrest in prostate cancer
Date:2/5/2013

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP. When the scientists inhibited the enzyme, the cancer cell proliferation was suppressed. The team led by Dr. Yury Ladilov from the Department of Clinical Pharmacology at the Ruhr-Universitt Bochum reported together with colleagues from the Department of Urology at the RUB and the Cornell University in New York in the "Journal of Biological Chemistry".

cAMP is generated at several locations in the cell

Cyclic AMP (cAMP) is a second messenger molecule that controls many processes ranging from cell growth to cell death. An enzyme located in the cell membrane, called adenylyl cyclase, produces the molecule. Generated at the cell membrane, cAMP affects, for example, ion channels or other enzymes which are anchored in the membrane. However, the messenger also influences intracellular processes in the nucleus or in the mitochondria, the powerhouses of the cell. The common view was that cAMP diffuses from the membrane through the cell liquid the cytosol to its destination. Recent studies, however, suggest that cAMP is not only produced at the cell membrane, but also in the cytosol by the enzyme soluble adenylyl cyclase (LAC). The function of LAC has so far barely been studied.

The enzyme LAC plays a role in cell division

In a previous study, the RUB-team from the Department of Clinical Pharmacology showed that LAC plays a role in programmed cell death. The scientists and their colleagues are now elucidating the function of the enzyme in proliferation of tumour cells. First, they examined tissue samples from patients. They compared the amount of LAC in cells of a malignant prostate tumour with the amount of LAC in cells taken from benign enla
'/>"/>

Contact: Yury Ladilov
yury.ladilov@rub.de
49-234-322-7639
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
2. Low oxygen levels could drive cancer growth
3. Report using private health claims data shows prices are driving health spending growth
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Disease that stunts infants growth traced to same gene that makes kids grow too fast
6. Scientists discover mechanism that promotes lung cancer growth and survival
7. Nerve growth factors elevated in pancreatic cancer model
8. Exercise Wont Affect Breast Milk, Babys Growth: Study
9. QTrade's New Facility Anticipates Dramatic Growth of Tea Industry
10. Rising Solar Engineering and Design Firm Enters 1.7 MW's in Connecticut ZREC Auction and Positions for Future Growth
11. Mahvrick Expands to Brazil, Russia, India, China to Support Existing Client Customer Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 Medical Solutions , ... happy to announce that our co-founder and CFO, ... Analysts’ Staffing 100 for 2014. Anderson was also ... influential people in the staffing industry,” in 2013.     ... 13th-largest healthcare staffing company in the U.S., was ...
(Date:10/22/2014)... October 22, 2014 Shriners Hospitals for ... will change the current location of Shriners Hospitals for ... Limestone across from the University of Kentucky Albert B. ... ambulatory care center, owned and operated by Shriners Hospitals ... needs of children and their families well into the ...
(Date:10/22/2014)... 22, 2014 Best Cheap Hosting USA ... world. The site has recently announced that iPower ( ... for people from around the world. , “iPower is ... today and is providing various kinds of useful products ... insists on offering excellent customer service and a number ...
(Date:10/22/2014)... of Prussia, PA (PRWEB) October 22, 2014 ... is recognized as an industry leader with over 25 ... award winning team leader in the areas related to ... addition, Mr. Carlson is an Editorial Advisory Board member ... Healthcare Council Educator. Blue Fin Group is a ...
(Date:10/22/2014)... Tara Haelle HealthDay ... Binge drinking among young adult men may lead to increased ... drinking didn,t cause a similar rise in blood pressure for ... In fact, when young adult women drank lightly or moderately, ... the study found. "This finding parallels studies in older ...
Breaking Medicine News(10 mins):Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4
... pneumococcal pneumonia -- a common bacterial pneumonia that can ... issue of Mayo Clinic Women's HealthSource is spreading the ... this form of pneumonia and reduces the serious complications ... of the vaccine, or may not know that they ...
... For some people, the most convenient approach is a ... to help burn calories and increase cardiovascular fitness.// ... health, some aerobic exercise machines may be more suited ... Health Letter covers some options: ,Treadmills: Generally ...
... been selected by the federal Department of Health and ... initiative, called “Own your future” carries a potent message; ... residents. ,Gov Perry while announcing the details of ... Texans age 45 to 65 to begin thinking about ...
... the capital, taking the toll to 25 Saturday while 95 ... number of dengue cases in Delhi has now risen to ... disease was 25-year-old Farahan of Delhi. She was brought to ... and died in the early hours of Saturday, said medical ...
... in recent studies that they are very beneficial to cardiac ... the heart according to the results of a study published ... 2006. ,Studies conducted have shown that PUFA helps to ... seen in cardiac function which usually reflects a bad prognosis, ...
... of Utah’s Huntsman Cancer Institute have discovered a new target ... is implicated in 85 percent of colon cancer cases. // ... – a molecule called C-Terminal Binding Protein (CTBP) researchers were ... in the adenomatous polyposis coli (APC) gene. ,In ...
Cached Medicine News:Health News:Home Is Where the Gym Is 2Health News:Dengue Claims Yet Another Victim in Delhi 2Health News:A New Way to Treat Colon Cancer? 2
(Date:10/22/2014)... , Oct. 22, 2014   Reproductive Medicine ... leader in the field of infertility, presents new ... embryonic screening. The research abstract, released during the ... Medicine (ASRM) meeting in Honolulu, Hawaii ... single gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  Paper ... products, has developed APLS ® Body Guard ... minimizes the spread of bacteria and virus while ... APLS Body Guard Bio features a rugged, external ... edges that create a leak-proof inner chamber that ...
(Date:10/22/2014)... A new report by Allied ... Form, End user, Application and Geography) - Size, Share, ... Opportunities, Segmentation and Forecast, 2013 - 2020", considers commercial ... key trends tracked, it is anticipated that the market ... 2020, registering a CAGR of 6.2% from 2014 to ...
Breaking Medicine Technology:New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
... (Nasdaq: BIOD ) today announced positive top-line ... product candidates, BIOD-123 and BIOD-125 -- two proprietary ultra-rapid-acting ... BIOD-123 and BIOD-125 achieved the Company,s target pharmacokinetic, pharmacodynamic ... BIOD-123 favored as lead product candidate to advance to ...
... 13, 2012  AATAC, AACSA, and SKYROCK retailers can expect ... sale to the general public. A marketing and distribution ... retailers to participate in the resale of this product ... counter top space alongside such products as 5-Hour Energy, ...
Cached Medicine Technology:Biodel Reports Positive Top-Line Results from Study of Experimental Ultra-Rapid-Acting Insulin Formulations 2Biodel Reports Positive Top-Line Results from Study of Experimental Ultra-Rapid-Acting Insulin Formulations 3Biodel Reports Positive Top-Line Results from Study of Experimental Ultra-Rapid-Acting Insulin Formulations 4Biodel Reports Positive Top-Line Results from Study of Experimental Ultra-Rapid-Acting Insulin Formulations 5Biodel Reports Positive Top-Line Results from Study of Experimental Ultra-Rapid-Acting Insulin Formulations 6Strategic Product Deployment Announcement: Clotamin 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: