Navigation Links
Growing up as a neural stem cell: The importance of clinging together and then letting go
Date:4/25/2012

em Cell Research Center scientist and senior author of the study. "If the neurons don't form at the proper time, it could lead to deficits in their numbers and to catastrophic, potentially fatal neurological defects."

During the first trimester of development, the neural stem and progenitor cells form a niche, or safe zone, within the nervous system. The neural stem and precursor cells adhere to each other in a way that allows them to expand their numbers and keep from differentiating. A protein called N-cadherin facilitates this adhesion, Novitch said.

When it is time for the neural precursors to become motor neurons, two proteins that repress gene expression, called Foxp2 and Foxp4, become elevated and then silence N-cadherin expression, causing the clustered neural stem and precursor cells to break apart and begin differentiating.

"We have these cells in a dividing state, making more of themselves, and to make neurons that process has to be stopped and those contacts between the cells disassembled," Novitch said. "Until now, it has not been clear how the cells are pulled apart."

Novitch and his team showed that if you eliminate Foxp protein function, motor neurons and other mature cells in the nervous system are not properly formed because the N-cadherin gene is not silenced, confirming the delicate balancing act that must be achieved for normal development of both the stem and precursor cells and their neuronal progeny.

"It's a fundamental discovery. Most studies have focused on defining what promotes the adhesiveness and self-renewal of neural stem cells, rather than what breaks these contacts," Novitch said. "We were also surprised to see how small changes in the degree of cell adhesion can markedly alter the development and structure of the nervous system. It's all about balance, if you have too many or too few stem and precursor cells, the result could be disastrous."

Going forward, Novitch and his
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Use of anesthesia providers during GI procedures is growing, but may be unnecessary
2. Kids Using Synthetic Pot a Growing Public Health Concern
3. Study reveals new wrinkle in growing US health gap
4. Scientific plagiarism: A growing problem in an era of shrinking research funding
5. Chronic Heartburn a Growing Problem in U.S.
6. Worlds Tiniest Preemies Growing Up Healthy: Report
7. Growing US violent extremism by the numbers: UMD database
8. Worlds tiniest preemies are growing up and doing fine
9. CU-Boulder led study of smoking twins points to growing influence of genetic factors
10. What can we learn from Americas fastest growing and least understood age group?
11. Sport tourism development book reveals new insights on growing leisure activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... (PRWEB) May 20, 2013 The ... Confectionery, Snacks, Breakfast Cereals, Baking Mixes & Flour, ... Conventional) & Geography — Global Trends & Forecasts ... product market with analysis and forecasting of the ... also identifies the driving and restraining factors for ...
(Date:5/20/2013)... 2013 B. E. Smith, the ... healthcare providers, has been retained to lead a ... Oswego Hospital in Oswego, N.Y. The top executive ... Smith has recently placed more than 900 healthcare ... a 164-bed, Joint Commission-accredited, acute care facility offering ...
(Date:5/20/2013)... Irritable Bowel Syndrome, or IBS, is commonly characterized ... habits, and is a difficult condition in which the ... of the colon may overreact to food, stress, exercise ... to an infection or a stressful life event. The ... a protein composite found in foods processed from wheat ...
(Date:5/20/2013)... 2013 The main objective for the present ... into a single comprehensive report. The objective was to ... this industry. Thus, it is timely to examine the ... an urgent need in the life science industry for technologies ... in a high-throughput, multiplex and low-cost way. Proteomic technologies ...
(Date:5/20/2013)... May 20, 2013 Pain Free ... relief products is excited to release a line ... arthritis pain relief. These magnetic health bracelets for ... with gemstones. Customers often report pain relief in ... demonstration at shows. , "Having made magnetic bracelets ...
Breaking Medicine News(10 mins):Health News:Gluten-Free Products Market to Reach $6,206.2 Million by 2018 at a CAGR of 10.2% - New Report by MarketsandMarkets 2Health News:Gluten-Free Products Market to Reach $6,206.2 Million by 2018 at a CAGR of 10.2% - New Report by MarketsandMarkets 3Health News:Oswego Hospital Retains B. E. Smith to Recruit New COO 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Offers improved hCG Diets With More Beneficial Nutritional Content, Possibly Offering Relief for Painful Symptoms of IBS 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Offers improved hCG Diets With More Beneficial Nutritional Content, Possibly Offering Relief for Painful Symptoms of IBS 3Health News:Proteomics Market - Mass Spectrometry & Biochips 2017 Forecast & Analysis in New Research Report at ReportsnReports.com 2Health News:Proteomics Market - Mass Spectrometry & Biochips 2017 Forecast & Analysis in New Research Report at ReportsnReports.com 3Health News:Handmade Magnetic Bracelets with Gemstones Announced by Pain Free Living 2
... , OAKBROOK TERRACE, Ill., Sept. 21 ... 2009 recipients of the annual John M. Eisenberg Patient Safety and Quality ... feature a new international category. , , ... INDIVIDUAL ACHIEVEMENT , Gary S. ...
... , Awardees will work with industry ... , WASHINGTON, Sept. 21 The U.S. Food ... stimulate the development and availability of medical devices for children. ... , , A panel of six experts with ...
... , Research features from Mayo Clinic , ... the fall issue of Discovery,s Edge, Mayo Clinic,s research magazine. ... wish. Reprinting is allowed with proper attribution. Please include the following subscription ... Discovery,s Edge for subscription information. , ...
... , , MONTREAL, ... integrated absence & disability management, today announced the release ... to comply with complex and overlapping FMLA (Family and ... regulations. Presagia,s ADA Toolkit will supplement Presagia,s Leave ...
... Dalton ... adding Formulation Development to its list of integrated capabilities. , ... Toronto, Ontario (PRWEB) September 21, 2009 -- ... by adding Formulation Development to its list of integrated capabilities. , , ...
... , , ... of emergency department (ED) clinical documentation tools, today announced it ... recent recommendations of the Centers for Disease Control and Prevention ... the T-System Web site ( www.tsystem.com/h1n1flu ), now ...
Cached Medicine News:Health News:2009 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 2Health News:2009 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 3Health News:2009 John M. Eisenberg Patient Safety and Quality Award Recipients Announced 4Health News:FDA Awards Three Grants Designed to Stimulate Development of Pediatric Medical Devices 2Health News:FDA Awards Three Grants Designed to Stimulate Development of Pediatric Medical Devices 3Health News:Discovery's Edge Fall Issue -- http://discoverysedge.mayo.edu/ 2Health News:Discovery's Edge Fall Issue -- http://discoverysedge.mayo.edu/ 3Health News:Presagia Solution Helps Employers Navigate Overlapping ADA and FMLA Regulations 2Health News:Presagia Solution Helps Employers Navigate Overlapping ADA and FMLA Regulations 3Health News:Dalton Pharma Services Adds Formulation Development Services 2Health News:T-System Updates Free Clinician H1N1 Templates to Latest CDC Guidelines, Adds Discharge Instructions 2Health News:T-System Updates Free Clinician H1N1 Templates to Latest CDC Guidelines, Adds Discharge Instructions 3
(Date:5/19/2013)... , May 19, 2013  The non-surgical ... low temperature radiofrequency (RF) energy is effective in ... or reduces the need for medication 10 years ... presented today at the Digestive Disease Week (DDW) ... Florida . "The sustained ...
(Date:5/18/2013)... The Open Paradigm Project, in collaboration ... Psychiatry , and leading organizations in the movement ... media campaign showcasing video testimonials by individuals negatively ... on pathology and illness rather than wellness and ... Association,s (APA) rollout of its latest revision of ...
(Date:5/17/2013)... , May 17, 2013 The power of ... important ways in which mankind depends on the plant ... Garden,s multifaceted exhibition Wild Medicine: Healing ... on view from May 18 through September 8, ... The featured exhibition,s many attractions include a re-creation ...
Breaking Medicine Technology:Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 2Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3Wild Medicine On View at The New York Botanical Garden Through Sept. 8 2
... FOLD ) today announced that John F. Crowley ... Chairman in order to devote more time to interests related ... role as Executive Chairman, Mr. Crowley will continue to perform ... will advise the current Amicus management team on corporate strategy ...
... The board of directors of Eli Lilly and Company (NYSE: ... second quarter of 2011 of $0.49 a share on outstanding ... 10, 2011 to shareholders of record at the close of ... innovation-driven corporation, is developing a growing portfolio of pharmaceutical products ...
Cached Medicine Technology:Amicus Therapeutics Announces Transition of John F. Crowley from Chairman and Chief Executive Officer to Executive Chairman 2
Duet Lumbar Allografts are comprised of a raised cancellous inner core providing biomechanical properties for rapid healing. Specially designed instruments facilitate the insertion of Duet Allografts...
Lumbar Allograft with Osteoactive advantage. Promotes bone formation and faster incorporation. Derived from the proven technology behind Grafton DBM. Maintains structural integrity and strength....
Seletz-Gelpi Laminectomy Retractor, self-retaining with arms bent at right angles....
Scoville-Haverfield Hemilaminectomy Retractor...
Medicine Products: