Navigation Links
Growing up as a neural stem cell: The importance of clinging together and then letting go
Date:4/25/2012

em Cell Research Center scientist and senior author of the study. "If the neurons don't form at the proper time, it could lead to deficits in their numbers and to catastrophic, potentially fatal neurological defects."

During the first trimester of development, the neural stem and progenitor cells form a niche, or safe zone, within the nervous system. The neural stem and precursor cells adhere to each other in a way that allows them to expand their numbers and keep from differentiating. A protein called N-cadherin facilitates this adhesion, Novitch said.

When it is time for the neural precursors to become motor neurons, two proteins that repress gene expression, called Foxp2 and Foxp4, become elevated and then silence N-cadherin expression, causing the clustered neural stem and precursor cells to break apart and begin differentiating.

"We have these cells in a dividing state, making more of themselves, and to make neurons that process has to be stopped and those contacts between the cells disassembled," Novitch said. "Until now, it has not been clear how the cells are pulled apart."

Novitch and his team showed that if you eliminate Foxp protein function, motor neurons and other mature cells in the nervous system are not properly formed because the N-cadherin gene is not silenced, confirming the delicate balancing act that must be achieved for normal development of both the stem and precursor cells and their neuronal progeny.

"It's a fundamental discovery. Most studies have focused on defining what promotes the adhesiveness and self-renewal of neural stem cells, rather than what breaks these contacts," Novitch said. "We were also surprised to see how small changes in the degree of cell adhesion can markedly alter the development and structure of the nervous system. It's all about balance, if you have too many or too few stem and precursor cells, the result could be disastrous."

Going forward, Novitch and his
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Use of anesthesia providers during GI procedures is growing, but may be unnecessary
2. Kids Using Synthetic Pot a Growing Public Health Concern
3. Study reveals new wrinkle in growing US health gap
4. Scientific plagiarism: A growing problem in an era of shrinking research funding
5. Chronic Heartburn a Growing Problem in U.S.
6. Worlds Tiniest Preemies Growing Up Healthy: Report
7. Growing US violent extremism by the numbers: UMD database
8. Worlds tiniest preemies are growing up and doing fine
9. CU-Boulder led study of smoking twins points to growing influence of genetic factors
10. What can we learn from Americas fastest growing and least understood age group?
11. Sport tourism development book reveals new insights on growing leisure activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 2014 Chromatography system is a ... various types of biological samples such as air ... mixture into two phase, namely mobile phase and ... run over the stationary phase, followed by the ... provide the separation of mixture. Chromatography system plays ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Micro irrigation ... ensure proper water dispersal as wells as to maintain ... agriculture is projected to become a dominant revenue generator ... sophisticated methods to reduce resource costs has led to ... and plantations, and has further caused massive demand for ...
(Date:7/13/2014)... According to a new market ... by Component (processor, GPU, DSP, connectivity), Technology Node ... Geography - Forecast and Analysis to 2014-2020", published ... Computing Market is expected to reach $61.70 Billion ... from 2014 to 2020. , Browse 71 market ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 The Pearland, Texas ... ranging in age from four months to 12 years of ... karate classes to birthday parties and Summer Camps, is now ... Little Gym of Pearland after spending over six years ... roles, including Gym Director. , Berry has over ten ...
(Date:7/13/2014)... 13, 2014 Max International ... Mullin, will be the featured guest at its Charity ... Puerto Rico. Attendees will learn about Max’s health ... two exhibition basketball games and perform in a 3 ... of health- and energy-boosting supplements , has recently announced ...
Breaking Medicine News(10 mins):Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 2Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 3Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 4
... HealthDay Reporter , THURSDAY, Nov. 4 (HealthDay News) ... cut mortality rates in older, current or former heavy smokers ... Given the large numbers of Americans who fall ill from ... 20 percent drop in deaths could be significant, experts noted. ...
... Nine years ago, scientists at Cedars-Sinai,s Maxine Dunitz Neurosurgical ... makeup of the most aggressive type of brain tumors, ... specific protein called laminin-411 plays a major role in ... support its growth and spread. But technology did not ...
... Most mutations in the genes of the Salmonella ... And this is the case regardless whether they lead to ... by Uppsala University scientists in an article being published today ... have examined the impact of mutations on the rate of ...
... News) -- During cold weather, the use of extra ... lead to dangerous overheating and increase the risk of ... Infants are sensitive to extremes in temperatures and have ... that multiple layers of clothing, heavy clothing, heavy blankets ...
... named Vinita Goyal, MD, MPH, its newest Women,s Reproductive ... Program was initiated in 1998 by the Eunice Kennedy ... (NICHD), in collaboration with the National Institutes of Health ... Infants and Brown University were awarded one of the ...
... HealthDay Reporter , THURSDAY, Nov. 4 (HealthDay News) ... in day care facilities that get meals and snacks through ... says. The report from the Institute of Medicine calls ... sugar. Many of the most needy children and adults ...
Cached Medicine News:Health News:CT Scans Seem to Lower Lung Cancer Death Rates 2Health News:CT Scans Seem to Lower Lung Cancer Death Rates 3Health News:CT Scans Seem to Lower Lung Cancer Death Rates 4Health News:Cedars-Sinai 'nano-drug' hits brain-tumor target found in 2001 2Health News:Cedars-Sinai 'nano-drug' hits brain-tumor target found in 2001 3Health News:Unexpectedly small effects of mutations in bacteria bring new perspectives 2Health News:Overheating in Infants Can Lead to SIDS, Experts Warn 2Health News:WRHR scholar to study contraception availability for female veterans 2Health News:WRHR scholar to study contraception availability for female veterans 3Health News:WRHR scholar to study contraception availability for female veterans 4Health News:U.S. Government Food Program Needs Improving: Report 2Health News:U.S. Government Food Program Needs Improving: Report 3
(Date:7/13/2014)... Auf seiner am ... veranstalteten F&E-Tagung meldete Astellas Fortschritte im ... Forschungsrahmenprogramms. Die Tagung bot Astellas die Gelegenheit, ... Programme und die Konzernstrategie des Unternehmens zu ... aktuelle Meldungen zu den Astellas-Initiativen in den ...
(Date:7/13/2014)... 13, 2014  Eli Lilly and Company (NYSE: ... its non-clinical study in genetically engineered mice examining ... beta-amyloid antibody N3pG and beta-secretase inhibitor BACE (LY2811376). ... effective in removing clumps of amyloid-beta protein in ... to lead to Alzheimer,s disease (AD) – than ...
(Date:7/11/2014)... LOS ANGELES , July 11, 2014 /PRNewswire-iReach/ ... of e-liquid, a vegetable-glycol solution for use in ... one of the active ingredients in cannabis, cannabidiol ... in personal vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds ...
Breaking Medicine Technology:Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 2Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 3Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 4New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 2New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 3VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2
... features a low molecular weight ... viscosity you need to achieve ... small-incision surgery. The sustained viscoelastic ... depth for safe, ample working ...
... CoEase is designed to provide excellent protection ... unique advantage of being closer to an ... This allows CoEase to maintain viscosity ... best of both worlds for superb performance ...
... ophthalmic viscosurgical device is a ... by high molecular weight, high ... It provides excellent space maintenance, ... easily removed. It is available ...
... DigitalCameras permit fundus imaging and documentation ... without any need for eyepieces guarantees ... Image recording and display is an ... the ophthalmoscope principle of modern fundus ...
Medicine Products: