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Grove Professor receives $1.5MM to study breast cancer therapies
Date:11/26/2012

y is adhesion of the drug delivery vehicle to tumor cells."

In previous research targeting cytokine-activated endothelial cells, Professor Auguste reported evidence that vehicles that complement the cell surface enhance binding.

Professor Auguste plans to encapsulate cancer drugs inside a lipid shell that will be very similar to a cell membrane and decorate the shell with one or more antibodies arranged in different ratios. She also intends to "play around" with the molecules' surface mobility and organization. "We'll test lots of different engineering parameters in order to achieve optimal efficacy."

To assess the effect of CEL on cell migration, activation survival and the EMT process, she will conduct mechanistic studies involving the expression of various proteins and enzymes.

Professor Auguste intends to demonstrate similarities and differences among six different breast cancer cell lines and deliver a platform technology designed to address tumor metastasis. The cell lines chosen represent the most metastatic and invasive forms of breast cancer with the poorest prognoses for survival. "We want to learn what is different about these breast cancers and whether we can develop a better treatment that can more effectively target the tumor and control it," she said.


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Contact: Ellis Simon
esimon@ccny.cuny.edu
212-650-6460
City College of New York
Source:Eurekalert

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