Navigation Links
Groundbreaking UK study shows key enzyme missing from aggressive form of breast cancer
Date:2/28/2013

LEXINGTON, Ky. (Feb. 28, 2013) A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells.

Normally, all cells including cancerous cells use glucose to initiate the process of making Adenosine-5'-triphosphate (ATP) for fuel to carry out essential functions. This process, called glycolysis, leads to other processes that use oxygen to make higher quantities of ATP but solid tumor cells, which have little access to oxygen, are forced to rely almost exclusively on aerobic glycolysis for survival.

Zhou's study, published in Cancer Cell, showed that the powerful transcription factor complex Snail-G9a-Dnmt1 is over-expressed in triple-negative breast cancer, inhibiting the enzyme 1,6-bisphosphate (FBP1). The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer. This metabolic switch empowers the triple-negative breast cancer cells to suck more glucose from the body, increasing macromolecule biosynthesis in tumor cells and maintaining ATP production despite a dearth of nutrients and an oxygen-free environment.

Triple-negative breast cancer is the most deadly subtype of breast cancer, and tends to occur in women at a younger age. This subtype of breast cancer has poor clinical outcomes due to the early metastasis of tumor cells, resistance to chemotherapy, and the lack of specific drugs that target it. Identifying this change in the cancer's metabolic process provides major insight into developing drugs to target the disease, Zhou says.

"These findings present significant insights regarding the development and progression of triple-negative breast cancer," said Zhou, associate professor of molecular and cellular biochemistry at UK. "They indicate that targeting the metabolic alteration will lead to an effective approach for treating this deadly disease."

Zhou's research was aided by the team in the Free Radical Biology in Cancer Shared Resource Facility (FRBC) of the Markey Cancer Center, directed by Dr. Allan Butterfield. The FRBC used an instrument called the Seahorse XF-96 Flux Analyzer to test and confirm the predictions of Zhou's findings in triple-negative breast cancer.

"The significance of this study rests in proving that triple negative breast cancer cells utilize glycolysis for survival and growth," Butterfield said. "The FRBC will assist Dr. Zhou in furthering this exciting research, potentially helping to identify key proteins in triple negative breast cancer cells that are expressed or modified differently than in control cells. Such knowledge may lead to new insights to potential approaches to treat this aggressive cancer."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Groundbreaking Training Video Prepares Surgical Team to Become Safest in the U.S.
2. Skin Authority Creates One-of-a-Kind Solution for the One Billion People Worldwide Who are Vitamin D Deficient -- Groundbreaking Launch of "Inside Out" System
3. Rectal microbicide research takes giant leap forward with groundbreaking educational video
4. MyPuress Releases Details About Groundbreaking New Product
5. JTCC researchers play important role in groundbreaking study that may change transplant practices
6. FEMA awards $1 Million to WPI to develop groundbreaking toxic gas sensors for firefighters
7. Groundbreaking clinical trial looks at fecal transplant as treatment for C. difficile
8. COPD Foundation and BWH announces second phase of groundbreaking COPDGene project
9. IU researchers interview pro-anorexic bloggers for groundbreaking new study
10. Groundbreaking Nigeria summit results in major commitment to reduce child deaths
11. Study identifies growth factor essential to the most common malignant pediatric brain tumor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... OSF ... group investing in InsightRX, an early stage company in San Francisco that has ... characteristics. Greatpoint Ventures Innovation Fund acted as the lead investor in ...
(Date:5/21/2017)... ... May 20, 2017 , ... GetLinked® ... Services and financial systems. , Dozens of clubs using ABC Financial Services ... processed through GetLinked into their club’s accounting system , The latest implementation is ...
(Date:5/21/2017)... ... May 21, 2017 , ... For the past ... group of scholars, policymakers, and activists wanting to address equity issues in breastfeeding, ... the third book from a recent series of from this conference. , ...
(Date:5/21/2017)... PA (PRWEB) , ... May 21, 2017 , ... Following ... 2012, New York became the first state to require that hospitals follow a protocol ... controversy in the medical community as to whether such steps would have saved Rory ...
(Date:5/19/2017)... Charlotte, NC (PRWEB) , ... May 19, 2017 ... ... of the Charlotte health community, Queens University of Charlotte recently began recruitment efforts ... The program’s curriculum arms students with the skills, knowledge and expertise to approach ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... 8, 2017 MACRA replaces the outdated ... for service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician ... 1.       The Market for MIPS Compliance Technology is Booming ... practices with 3 or more clinicians seek to buy ... "Given the magnitude of the changes, the hunt is ...
(Date:5/6/2017)... -- May is Stroke Awareness Month and Omron Healthcare is ... to prevent a stroke: monitor and manage your blood ... Prevention, undetected and uncontrolled hypertension is a leading risk ... in personal heart health technology, recently evolved its mission ... stroke and is advancing a national public education effort ...
(Date:5/4/2017)... May 4, 2017  A recent study published ... Ultraviolet-C light as a means of disinfection ... to reduce bioburden on anesthesia workstations. In the ... high-touch, complex medical equipment surfaces contaminated with three ... "This study further validates the body of ...
Breaking Medicine Technology: