Navigation Links
Grid computing offers new hope in race against bird flu

Budapest, 4 October 2007 -- Last month a collaboration of European and Asian researchers launched a new attack against the deadly bird flu virus, harnessing the combined power of more than 40,000 computers across 45 countries to boost the pace of anti-viral drug discovery.

Called Enabling Grids for E-sciencE, the computing grid connects ordinary PCs to form a super-sized supercomputer that is being used during this challenge to analyse the potential of more than 500,000 drug-like molecules over the next few weeks.

This effort comes as new data released last week by Peking University in Beijing, China, shows that the H5N1 bird flu virus can pass through the placenta of pregnant women to the unborn fetus, and can infect organs other than the lungs in adults. A rapid response to any pandemic outbreak of the virus would be essential to its control.

Dr Ying-Ta Wu, biologist at the Genomics Research Center of the Academia Sinica, says computing grids like EGEE are the fastest and cheapest way to discover new drug leads.

We are using EGEE to find new molecules that can inhibit the activities of the influenza virus, Dr Ying-Ta Wu explains During previous challenges using the EGEE grid we discovered about 200 molecules with the potential to become drugs against bird flu.

The EGEE computing grid powers drug discovery software that allows researchers to compute the probability that a drug-like molecule will dock with active sites on the virus and thus inhibit its action. Using the results of such in silico screening, researchers can predict which compounds are most effective at blocking the virus. This accelerates the discovery of novel potent inhibitors by minimising the non-productive trial-and-error approach in a laboratory.

Asian flu remains a threat to world health and we are well aware that any pandemic could quickly spread throughout Europe" said Viviane Reding, European Commissioner for Information Society and Media. "I am pleased that the European project EGEE has found such an important application for computer grid technology as speeding-up drug discovery against neglected and emerging diseases. Collaboration between Europe and Asia is essential if we are to address world wide threats to public health.

At the EGEE07 conference in Budapest, Ulf Dahlsten, Director of Emerging Technologies and Infrastructures in the Information Society and Media Directorate-General of the European Commission, used the example of EGEEs success with bird flu to illustrate the potential contributions of e-Infrastructures to science. "Computer Grids have achieved a productivity increase of more than 6000% in the identification of potential new drugs" he said. "300,000 molecules have already been screened using the EGEE grid. Of these, 123 potential inhibitors were identified, of which seven have now been shown to act as inhibitors in in-vitro laboratory tests. This is a six percent success rate compared to typical values of around 0.1 percent using classical drug discovery methods."


Contact: Sarah Purcell

Related medicine news :

1. Pancreatitis: Minimially Invasive Procedure Offers Long-Term Pain Relief
2. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
3. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
4. Roche offers HIV drug expertise to poor nations
5. Magnesium sulfate offers no help in migraine treatment
6. Drug Offers Hope for Alzheimers disease
7. Drug Firm Offers to Donate Smallpox Vaccine
8. fMRI Offers Insight Into An Infants Brain
9. Gel Offers A More Targeted Approach
10. Umbilical Cord Blood Offers Hope For Patients Who Require Bone Marrow Transplants
11. Surgery Offers Better Treatment For Third Degree Piles
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... RoamRight, a leading provider of ... Public Television’s Travel With Kids to promote family vacations around the world. ... they explore international destinations and educate families about the people and places of the ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), ... University. , Their study showed that small molecule analogs that target the functions ...
(Date:11/30/2015)... ... 30, 2015 , ... At Grand Dental PC, their priority is to deliver ... have dental problems, you need to turn to a dentist who listens and responds; ... needs, a friendly dentist who counsels you on the best ways to maintain and ...
(Date:11/30/2015)... ... November 30, 2015 , ... Using a combination of ... in American children and adults, according to a new study by researchers at the ... Prediabetes in Children and Adults: Using Combinations of Blood Glucose Tests ,” published in ...
(Date:11/30/2015)... ... 2015 , ... Newly reviewed and approved “NJ Top Dentist”, ... He has both advanced training and considerable experience in reconstructive dentistry with attention ... cosmetic dentistry. He is an active Spear Education member providing full mouth ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 iCAD, Inc. (Nasdaq: ICAD ... latest solutions for advanced image analysis and workflow ... the Radiological Society of North American (RSNA) 2015 ... from November 29 to December 4, 2015. The ... an automated breast density assessment solution, PowerLook® Advanced ...
(Date:11/30/2015)... Texas , Nov. 30, 2015  Hanger, Inc. ... amendment and restatement of the terms of its previously ... Solicitation") relating to its $200,000,000 aggregate principal amount 7⅛% ... other things, (i) the consent fees payable pursuant to ... on the Notes and (iii) the expiration date of ...
(Date:11/30/2015)... Mexico Healthcare and Life Sciences Report 2015 . --> ... Pharmaboardroom releases its new 98-page Mexico Healthcare and Life Sciences ... country of over 122 million people. --> Latin ... --> It offers companies, investors, policymakers, and stakeholders with an ... largest pharma and healthcare market in Latin America ...
Breaking Medicine Technology: