Navigation Links
Green tea chemical combined with another may hold promise for treatment of brain disorders
Date:12/3/2009

in yeast.

In their new study, the team decided to look in more detail at the impact of these two chemicals on the production of different amyloids produced by the yeast amyloid protein known as PSI+. They chose this yeast amyloid protein because it has been studied extensively in the past, and because it produces varieties of amyloid structures that are prototypes of those found in the damaged human brain. Thus, PSI+ amyloids are excellent experimental paradigms to study basic properties of all amyloid proteins.

The team's first step was to expose two different amyloid structures produced by yeast (e.g., a weak version and a strong version) to EGCG. They found that the EGCG effectively dissolved the amyloids in the weaker version. To their surprise, they found that the stronger amyloids were not dissolved and that some transformed to even stronger versions after exposure to EGCG.

The team then exposed the yeast amyloid structures to a combination of the EGCG and the DAPH-12 and found that all of the amyloid structures broke apart and dissolved.

The next steps for the research team will be to explore the mechanism and potency of such a combinatorial therapy for the treatment of diverse neurodegenerative diseases.

"Our findings are certainly preliminary and we need further work to fully comprehend the effects of EGCG in combination with other chemicals on amyloids. Yet, we see our study as a very exciting initial step towards combinatorial therapies for the treatment of amyloid-based diseases," says Duennwald.


'/>"/>

Contact: patti Jacobs
pjacobs12@comcast.net
617-864-2712
Boston Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Text Messages from Santa
2. Santa goes GREEN by going MOBILE for The March of Dimes
3. Cutting greenhouse pollutants could directly save millions of lives worldwide
4. Statement of Robert Greenstein, Executive Director, Center on Budget and Policy Priorities, on the New Senate Health Reform Bill
5. Antifibrotic effects of green tea
6. Greenway Medical Technologies Enhances Advisory and Consulting Partnership Strategies with Regional Extension Centers
7. Georgia Power, Centers for Disease Control and Prevention Forge Green Energy Partnership
8. US Farms, Inc. Announces Completion of Construction for New 3000 Square Foot Greenhouse Shipping and Packing Facility for Nursery Division
9. GREENGUARD Launches Comprehensive Health-Based Certification Pilot Program
10. Green Living Expert Annie B. Bond's Natural Flu Protection Kit
11. Green Tea May Help Prevent Oral Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Washington State University Spokane have developed a new ... nod off behind the wheel. , Their recently ... are more variable in drowsy driversand offers an ... video-based driver drowsiness detection systems. , Van Dongen"Video-based ... car is drifting out of its lane are ...
(Date:4/23/2014)... Society for Radiation Oncology (ASTRO) has issued a ... for Endometrial Cancer: An ASTRO Evidence-Based Guideline," that ... the treatment of endometrial cancer. The guideline,s executive ... of Practical Radiation Oncology (PRO), the ... guideline is available as an open-access article online ...
(Date:4/23/2014)... pathway that helps prevent new cells from receiving too ... been directly linked to cancer and other diseases. , ... the end of cell division, the enzyme Cdc14 activates ... are fully repaired before the parent cell distributes copies ... safeguard against some of the most devastating genome errors, ...
(Date:4/23/2014)... 2014Men whose testosterone falls below normal levels are more ... and have heart disease and type 2 diabetes. A ... for further testing and possible treatment is described in ... a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. ... of Men,s Health website at http://www.liebertpub.com/jmh . ...
(Date:4/23/2014)... 23, 2014) The American Gastroenterological Association (AGA) ... AGA Research Scholars. The AGA Research Scholar Awards ... develop independent and productive research careers in digestive ... fund an additional year allowing for three consecutive ... supporting junior faculty who are paving the way ...
Breaking Medicine News(10 mins):Health News:WSU innovation improves drowsy driver detection 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2Health News:AGA announces 2014 Class of AGA Research Scholars 2
... Scientists have determined how to fortify the cassava ... with enough vitamins, minerals and protein to provide the ... in a single meal. , The researchers have further ... crop,s most damaging viral threats and are refining methods ...
... in Spanish . , The " La Mente ... Faculty of Arts at the University of the Basque Country analyses ... the brain acquires and manages languages and to discover in what ... , In order to understand how we become fluent in ...
... Facts panel makes it tough to make healthy choices, study ... 4 grams of trans fats in a serving of baked or ... , Answer: It,s always unhealthy, since no amount of ... new study suggests that the Nutrition Facts panel found on the ...
... Compliance -, LEXINGTON, Mass., June 30th ... the prestigious Supplier,Performance Award from Premier, Inc. for ... in quality and compliance by,Premier vendors, with less ... presented with the honor at Premier,s 2008 Annual ...
... June 30 Cadient Group, the,premier strategic interactive ... Stephen Wray, President and CEO of Cadient,Group, was ... The Year(R) in the,Greater Philadelphia region. According to ... recognize outstanding entrepreneurs on a regional, national,and global ...
... India, June 30 Sun Pharmaceutical,Industries Ltd. (Reuters: ... announced that Alkaloida Chemical Company Exclusive Group,Ltd. (Alkaloida), ... tender offer,for all outstanding Ordinary Shares of Taro ... in cash., On May 18, 2007, Taro ...
Cached Medicine News:Health News:Fortified cassava could provide a day's nutrition in a single meal 2Health News:Fortified cassava could provide a day's nutrition in a single meal 3Health News:Fortified cassava could provide a day's nutrition in a single meal 4Health News:Laka: 'Language exists in the brain' 2Health News:Laka: 'Language exists in the brain' 3Health News:Laka: 'Language exists in the brain' 4Health News:Trans Fat Labeling Gets Tricky 2Health News:Trans Fat Labeling Gets Tricky 3Health News:Trans Fat Labeling Gets Tricky 4Health News:Trans Fat Labeling Gets Tricky 5Health News:Instrumentation Laboratory Receives Performance Award from Premier for Second Consecutive Year 2Health News:Cadient Group President and CEO, Stephen Wray, Named 2008 Ernst & Young Entrepreneur Of The Year(R) in Greater Philadelphia Region 2Health News:Cadient Group President and CEO, Stephen Wray, Named 2008 Ernst & Young Entrepreneur Of The Year(R) in Greater Philadelphia Region 3Health News:Sun Pharma Commences All Cash Tender Offer to Purchase Taro Ordinary Shares for USD 7.75 Per Share 2Health News:Sun Pharma Commences All Cash Tender Offer to Purchase Taro Ordinary Shares for USD 7.75 Per Share 3
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... LEESBURG, Va. , Jan. 14, 2014 Animal Emergency Critical ... in Leesburg, Virginia is the first in ... hyperbaric oxygen chamber. Dr. Susan M. Barnes ... years. Dr. Barnes and husband, Dr. Cole Taylor , are ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation partner to organizations ... May 14-16, 2014 at the Global Center for Health ... This is the premier industry event for ... open innovation. Participants will learn how world-changing innovation is ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... /PRNewswire-FirstCall/ -- Echo Therapeutics, Inc. (OTC ... the needle-free Symphony(TM) tCGM System as a non-invasive, ... the Prelude(TM) SkinPrep System for transdermal drug delivery, ... to the development of its needle-free Symphony tCGM ...
... MILAN, October 29 Mirial has just released ... which explains in details the benefits of Telehealth and ... , Widening the original scope ... Telehealth is meant to support also the preventive,and promotive ...
Cached Medicine Technology:Echo Therapeutics Announces Significant Advance in Development of its One-Piece, Needle Free Symphony tCGM Biosensor 2Echo Therapeutics Announces Significant Advance in Development of its One-Piece, Needle Free Symphony tCGM Biosensor 3Whitepaper From Mirial Explains how Visual Communication Technology can Improve Healthcare Services 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: