Navigation Links
Green tea chemical combined with another may hold promise for treatment of brain disorders
Date:12/3/2009

Watertown, MAScientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein structures known as amyloids. Amyloids are the primary culprits in fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's diseases. Their study, published in the current issue of Nature Chemical Biology (December 2009), may ultimately contribute to future therapies for these diseases.

"These findings are significant because it is the first time a combination of specific chemicals has successfully destroyed diverse forms of amyloids at the same time," says Dr. Martin Duennwald of BBRI, who co-led the study with Dr. James Shorter of University of Pennsylvania School of Medicine.

For decades a major goal of neurological research has been finding a way to prevent the formation of and to break up and destroy amyloid plaques in the brains and nervous systems of people with Alzheimer's and other degenerative diseases before they wreak havoc.

Amyloid plaques are tightly packed sheets of proteins that infiltrate the brain. These plaques, which are stable and seemingly impenetrable, fill nerve cells or wrap around brain tissues and eventually (as in the case of Alzheimer's) suffocate vital neurons or brain cells, causing loss of memory, language, motor function and eventually premature death.

To date, researchers have had no success in destroying plaques in the human brain and only minimal success in the laboratory. One reason for these difficulties in finding compounds that can dissolve amyloids is their immense stability and their complex composition.

Yet, Duennwald experienced success in previous studies when he exposed amyloids in living yeast cells to EGCG. Furthermore, he and his collaborators also found before that DAPH-12, too, inhibits amyloid production in yeast.

In their new study, the team decided to look in more detail at the impact of these two chemicals on the production of different amyloids produced by the yeast amyloid protein known as PSI+. They chose this yeast amyloid protein because it has been studied extensively in the past, and because it produces varieties of amyloid structures that are prototypes of those found in the damaged human brain. Thus, PSI+ amyloids are excellent experimental paradigms to study basic properties of all amyloid proteins.

The team's first step was to expose two different amyloid structures produced by yeast (e.g., a weak version and a strong version) to EGCG. They found that the EGCG effectively dissolved the amyloids in the weaker version. To their surprise, they found that the stronger amyloids were not dissolved and that some transformed to even stronger versions after exposure to EGCG.

The team then exposed the yeast amyloid structures to a combination of the EGCG and the DAPH-12 and found that all of the amyloid structures broke apart and dissolved.

The next steps for the research team will be to explore the mechanism and potency of such a combinatorial therapy for the treatment of diverse neurodegenerative diseases.

"Our findings are certainly preliminary and we need further work to fully comprehend the effects of EGCG in combination with other chemicals on amyloids. Yet, we see our study as a very exciting initial step towards combinatorial therapies for the treatment of amyloid-based diseases," says Duennwald.


'/>"/>

Contact: patti Jacobs
pjacobs12@comcast.net
617-864-2712
Boston Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. Text Messages from Santa
2. Santa goes GREEN by going MOBILE for The March of Dimes
3. Cutting greenhouse pollutants could directly save millions of lives worldwide
4. Statement of Robert Greenstein, Executive Director, Center on Budget and Policy Priorities, on the New Senate Health Reform Bill
5. Antifibrotic effects of green tea
6. Greenway Medical Technologies Enhances Advisory and Consulting Partnership Strategies with Regional Extension Centers
7. Georgia Power, Centers for Disease Control and Prevention Forge Green Energy Partnership
8. US Farms, Inc. Announces Completion of Construction for New 3000 Square Foot Greenhouse Shipping and Packing Facility for Nursery Division
9. GREENGUARD Launches Comprehensive Health-Based Certification Pilot Program
10. Green Living Expert Annie B. Bond's Natural Flu Protection Kit
11. Green Tea May Help Prevent Oral Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , ... (PRWEB) May ... three new members of its Advisory Board. Joining the Grow ... Kusch. “All three of them embody the mission of our organization ... very fortunate to have them as we continue to expand our ...
(Date:5/24/2016)... ... May 24, 2016 , ... Physical therapy is ... repairing the musculoskeletal and neuromuscular systems of the human body without recourse to ... providing treatments for physical therapy in New York, including dynamic neuromuscular stabilization ...
(Date:5/24/2016)... ... May 24, 2016 , ... Backed by decades of experience, ... job, ensuring the best suited solution to meet regulatory requirements. Their professional staff ... lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s line of medical and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Eggsurance, the first ... relaunch of its community and education hub for women considering fertility preservation, as ... create a safe and welcoming place for women to find cycle buddies, get ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society (RSS), a ... is recognizing five medical residents and students for their outstanding contributions to research ... awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking place June ...
Breaking Medicine News(10 mins):
(Date:5/20/2016)... 2016 ReportsnReports.com adds Global ... Devices of its online business intelligence library. This ... current state of the Titrator industry. The report ... definitions, classifications, Specifications, applications and industry chain structure. ... Raw Material Suppliers, Equipment Suppliers, Manufacturing Cost Structure, ...
(Date:5/20/2016)... 20, 2016 - Revenue ... Insulins, Growth Hormones, Recombinant Coagulation Factors and Regenerative ... This New Study Reveals Selling Opportunities and Revenue ... ,What is the future of biologics, especially ... and commercial analysis. Staying ahead in data and ...
(Date:5/20/2016)... , May 20, 2016 ... Review, H1 2016" market research report with comprehensive ... (Psoriasis Vulgaris), complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ... and press releases. It also reviews key players ...
Breaking Medicine Technology: