Navigation Links
Green tea chemical combined with another may hold promise for treatment of brain disorders
Date:12/3/2009

Watertown, MAScientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein structures known as amyloids. Amyloids are the primary culprits in fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's diseases. Their study, published in the current issue of Nature Chemical Biology (December 2009), may ultimately contribute to future therapies for these diseases.

"These findings are significant because it is the first time a combination of specific chemicals has successfully destroyed diverse forms of amyloids at the same time," says Dr. Martin Duennwald of BBRI, who co-led the study with Dr. James Shorter of University of Pennsylvania School of Medicine.

For decades a major goal of neurological research has been finding a way to prevent the formation of and to break up and destroy amyloid plaques in the brains and nervous systems of people with Alzheimer's and other degenerative diseases before they wreak havoc.

Amyloid plaques are tightly packed sheets of proteins that infiltrate the brain. These plaques, which are stable and seemingly impenetrable, fill nerve cells or wrap around brain tissues and eventually (as in the case of Alzheimer's) suffocate vital neurons or brain cells, causing loss of memory, language, motor function and eventually premature death.

To date, researchers have had no success in destroying plaques in the human brain and only minimal success in the laboratory. One reason for these difficulties in finding compounds that can dissolve amyloids is their immense stability and their complex composition.

Yet, Duennwald experienced success in previous studies when he exposed amyloids in living yeast cells to EGCG. Furthermore, he and his collaborators also found before that DAPH-12, too, inhibits amyloid production
'/>"/>

Contact: patti Jacobs
pjacobs12@comcast.net
617-864-2712
Boston Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Text Messages from Santa
2. Santa goes GREEN by going MOBILE for The March of Dimes
3. Cutting greenhouse pollutants could directly save millions of lives worldwide
4. Statement of Robert Greenstein, Executive Director, Center on Budget and Policy Priorities, on the New Senate Health Reform Bill
5. Antifibrotic effects of green tea
6. Greenway Medical Technologies Enhances Advisory and Consulting Partnership Strategies with Regional Extension Centers
7. Georgia Power, Centers for Disease Control and Prevention Forge Green Energy Partnership
8. US Farms, Inc. Announces Completion of Construction for New 3000 Square Foot Greenhouse Shipping and Packing Facility for Nursery Division
9. GREENGUARD Launches Comprehensive Health-Based Certification Pilot Program
10. Green Living Expert Annie B. Bond's Natural Flu Protection Kit
11. Green Tea May Help Prevent Oral Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 ASCNYC (ascnyc.org) ... that helps New Yorkers living with HIV/AIDS and ... health, housing, recovery and self-sufficiency. Each year, ASCNYC ... local community through their tireless efforts. , ... Shapses , has been selected as this year’s ...
(Date:10/20/2014)... JZ Fitness, an independently operated wellness ... programming, authorship, international lecturing and community wellness, created by ... release of the JZ Fitness nutrition app, available on ... thousands of individuals on nutrition, Jenn Zerling (“JZ”) has ... require calorie counting or cumbersome food logging. ...
(Date:10/20/2014)... OH (PRWEB) October 20, 2014 ... Assisted Living Center on Oct. 14. The $11 million ... and services, and a cooked-to-order kitchen with full-service restaurant ... Akron’s premier choice for first class Assisted Living apartments,” ... “Our residents deserve the highest quality of care and ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The Center ... hospital ROI on membership dues at 12.5. In other words, ... in value to member hospitals. The calculation used to determine ... , “This is the first time we’ve actually been ... methodology is really sound,” said Bill Ryan , president ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal ... throughout the greater Phoenix area and across Arizona reports ... to catastrophic automobile accidents. Statistics have indicated a steady ... Arizona. As such, Hastings and Hastings has seen a ... those who have been injured through no fault of ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3
... Excluding children from discussions about their hospital care can make ... Parents and medical professionals need to make an effort to ... researchers from Dublin, Ireland. The study authors interviewed 55 ... and found that the kids wanted to be included in ...
... HIV testing at local emergency departments shows that hospitals miss ... infected with HIV, even when a regular testing program is ... supplement to the July issue of Annals of Emergency ... Prevention (CDC). The supplement includes a series of studies on ...
... - The European Commission,s Joint Research Centre has developed ... which can be found in sports drinks imported from ... informed the European Commission that significant amounts of phthalates ... These chemicals are believed to affect reproductive performance and ...
... blood pressure while undergoing dialysis has long vexed many kidney ... term range from stroke to seizure to heart damage to ... muscular and neurologic symptoms. Now one more disturbing side ... study led by researchers at the Stanford University School of ...
... the thousands of patients who receive kidney transplants ... rejection without compromising other aspects of health requires ... protect transplanted organs can also cause serious side ... and other threats. Finding the best combination and ...
... HealthDay Reporter , THURSDAY, July 28 (HealthDay News) -- ... the lyrics of a classic song about baseball. A new ... playing time and avoid pitting one kid against another may end ... "The big thing here is to create a climate where the ...
Cached Medicine News:Health News:Study Finds Kids Want More Info About Their Hospital Care 2Health News:Study shows missed opportunities for HIV diagnosis in emergency departments 2Health News:Study shows missed opportunities for HIV diagnosis in emergency departments 3Health News:JRC develops new testing methods for contaminated sports drinks from Taiwan 2Health News:Low blood pressure during dialysis increases risk of clots, according to Stanford-led study 2Health News:Best post-transplant drug regimen identified for patients with new kidneys 2Health News:Coaches Can Play Big Role in How Kids Feel About Sports 2Health News:Coaches Can Play Big Role in How Kids Feel About Sports 3
(Date:10/20/2014)... 2014 Pharmaceutic Labs announces the opening of ... Albany, NY for admixing, compounding, drug shortages ... exceeds the FDA standards for safety and quality, using ... The 10,000 square foot outsourcing facility ... assurance and quality control. The company will produce sterile ...
(Date:10/20/2014)... , October 20, 2014 ... of its novel, low volume bowel preparation, NER1006, presented ... the American College of Gastroenterology (ACG), Philadelphia, ... point of stool weight and co-primary endpoint of cleansing ... with NER1006 vs. MOVIPREP ® in screening colonoscopy ...
(Date:10/19/2014)... DUBLIN , October 20, 2014 Shire ... James Bowling , Interim Chief Financial Officer (CFO), has notified the ... current role to pursue a new career opportunity as CFO of ... Q1 2015 and the company will commence a search for a ... commented: "James has helped build and lead a high-quality ...
Breaking Medicine Technology:Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: