Navigation Links
'Green chemistry' could ease manufacture, boost usefulness of cancer drug
Date:4/2/2009

EAST LANSING, Mich. --- Research by Michigan State University chemist Kevin Walker is paving the way for potentially cleaner, more efficient production of cancer-fighting paclitaxel -- better known as the blockbuster drug Taxol.

First isolated from the bark of the Pacific yew in 1967, paclitaxel has since been made by synthetically modifying an intermediate substance isolated from yew needles using toxic solvents or by fermenting cell cultures.

Walker's method employs natural enzymes instead. "Pharmaceutical companies could reduce the steps involved in making Taxol," he said, "while cutting chemical byproducts."

Walker, an assistant professor of chemistry, biochemistry and molecular biology, studies enzymes that assemble the Taxol molecule in Taxus plants. "This process is like painting from a palette," Walker said. "We can add select colors to the palette from which the enzyme chooses, so the molecule can be crafted in a variety of ways. The enzyme does all the work.

"A plant enzyme can do in one step what traditional synthetic construction does in multiples steps," Walker said. "Under our process, the construction of Taxol uses a biological assembly line where each enzyme does its job to create the final product. Particular enzymes on the assembly line can attach slightly different components on the molecular frame to create new-generation Taxol molecules. This can lead to more effective drug variants and eventually better health care treatment."

Taxol "is definitely a frontline drug and is used to treat many cancers," including those of the breast, lung, head and neck, said Barbara Conley, chief of the MSU Department of Medicine's hematology and oncology division.

With a world bulk paclitaxel market generating revenues of $195 million in 1997, potential new uses for conditions such as Alzheimer's disease and tuberculosis are expected to help boost the world market 10 percent by 2012, according to Global Industry Analysts Inc.

Walker's team's research was funded by the Michigan Agricultural Experiment Station. "The science and technology of plants and natural systems is becoming increasingly relevant in human medicine as scientists look for greater efficiencies and 'greener' ways of manufacturing drugs and other health care products," said MAES director Steve Pueppke. "Engaging in research that leads to improvements in human and animal health is a large and important part of the MAES mission."

us plants. "This process is like painting from a palette," Walker said. "We can add select colors to the palette from which the enzyme chooses, so the molecule can be crafted in a variety of ways. The enzyme does all the work.

"A plant enzyme can do in one step what traditional synthetic construction does in multiples steps," Walker said. "Under our process, the construction of Taxol uses a biological assembly line where each enzyme does its job to create the final product. Particular enzymes on the assembly line can attach slightly different components on the molecular frame to create new-generation Taxol molecules. This can lead to more effective drug variants and eventually better health care treatment."

Taxol "is definitely a frontline drug and is used to treat many cancers," including those of the breast, lung, head and neck, said Barbara Conley, chief of the MSU Department of Medicine's hematology and oncology division.

With a world bulk paclitaxel market generating revenues of $195 million in 1997, potential new uses for conditions such as Alzheimer's disease and tuberculosis are expected to help boost the world market 10 percent by 2012, according to Global Industry Analysts Inc.

Walker's team's research was funded by the Michigan Agricultural Experiment Station. "The science and technology of plants and natural systems is becoming increasingly relevant in human medicine as scientists look for greater efficiencies and 'greener' ways of manufacturing drugs and other health care products," said MAES director Steve Pueppke. "Engaging in research that leads to improvements in human and animal health is a large and important part of the MAES mission."


'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Green Tea May Brew Up Healthier Skin
2. Lettuce, leafy greens and E. coli
3. Houston Texans Star Players Ahman Green and Matt Schaub Help Easter Seals, Avondale House and Local Families Tackle Autism
4. ComPsych(R) Corp. Announces Health at Work(SM) Award Winners: Sprint, Erie Insurance, City of Naperville and Green Hills Public Library
5. Statement by Robert Greenstein, Executive Director of the Center on Budget and Policy Priorities, on the New Congressional SCHIP Agreement
6. Green Seal Ramps Up Environmental Standard for Household Cleaners
7. PureCart Systems of Green Bay, Wis., is an Honored Recipient of an iParenting Media Award
8. Kaiser Permanente Named Green Electronics Champion by EPA, Green Electronics Council
9. Walgreens Launches New Health Essentials Catalog and Website for AARP Members Featuring More Than 20,000 Health-Related Products
10. Green Pet Products Introduces a New, Innovative Process to the Small Animal and Bird Litter/Bedding Category
11. A History of Philanthropy Made Green-certified Legend Homes an Easy Choice for Extreme Makeover: Home Edition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Green chemistry' could ease manufacture, boost usefulness of cancer drug
(Date:4/28/2017)... Salt Lake City, UT (PRWEB) , ... April 28, 2017 , ... ... that exist in some of their formulas. This begins with the popular ClearLungs Extra ... impacted, they will be changing the formula in the following ways:, ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... http://www.foodsthathealdaily.com , http://www.wiredlifesolutions.com , “Computers are everywhere and they’re here to ... of Water, Global Climate Change and Your Health on Voice America sponsored by ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and ... more adverse experiences than children in the general population. That’s because foster care ... or other family challenges. While no fault of their own, youth who have ...
(Date:4/28/2017)... ... , ... People are starting to accept that hearing aids can be helpful ... stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. Maura ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing aid ...
(Date:4/28/2017)... ... April 28, 2017 , ... Phytomer ... East region. Côté has 20+ years of experience within the beauty industry, ranging ... with an array of high-end cosmetic brands, retail brands and outlets in Canada ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... LONDON , April 19, 2017 ... to stimulate an immune response in pets such ... vaccine products are of various types such as ... Vaccines, Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. ... such as virus or bacteria, which have been ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
(Date:4/18/2017)... -- Astute Medical, Inc., developer of biomarkers for better healthcare, ... the 2017 National Kidney Foundation (NKF) Spring Clinical ... 22. Physicians will present data on two biomarkers, ... acute kidney injury (AKI) during the management of patients ... Elevated levels of TIMP-2 and IGFBP-7 have been shown ...
Breaking Medicine Technology: