Navigation Links
'Green chemistry' could ease manufacture, boost usefulness of cancer drug
Date:4/2/2009

EAST LANSING, Mich. --- Research by Michigan State University chemist Kevin Walker is paving the way for potentially cleaner, more efficient production of cancer-fighting paclitaxel -- better known as the blockbuster drug Taxol.

First isolated from the bark of the Pacific yew in 1967, paclitaxel has since been made by synthetically modifying an intermediate substance isolated from yew needles using toxic solvents or by fermenting cell cultures.

Walker's method employs natural enzymes instead. "Pharmaceutical companies could reduce the steps involved in making Taxol," he said, "while cutting chemical byproducts."

Walker, an assistant professor of chemistry, biochemistry and molecular biology, studies enzymes that assemble the Taxol molecule in Taxus plants. "This process is like painting from a palette," Walker said. "We can add select colors to the palette from which the enzyme chooses, so the molecule can be crafted in a variety of ways. The enzyme does all the work.

"A plant enzyme can do in one step what traditional synthetic construction does in multiples steps," Walker said. "Under our process, the construction of Taxol uses a biological assembly line where each enzyme does its job to create the final product. Particular enzymes on the assembly line can attach slightly different components on the molecular frame to create new-generation Taxol molecules. This can lead to more effective drug variants and eventually better health care treatment."

Taxol "is definitely a frontline drug and is used to treat many cancers," including those of the breast, lung, head and neck, said Barbara Conley, chief of the MSU Department of Medicine's hematology and oncology division.

With a world bulk paclitaxel market generating revenues of $195 million in 1997, potential new uses for conditions such as Alzheimer's disease and tuberculosis are expected to help boost the world market 10 percent by 2012, according to Global Industry Analysts Inc.

Walker's team's research was funded by the Michigan Agricultural Experiment Station. "The science and technology of plants and natural systems is becoming increasingly relevant in human medicine as scientists look for greater efficiencies and 'greener' ways of manufacturing drugs and other health care products," said MAES director Steve Pueppke. "Engaging in research that leads to improvements in human and animal health is a large and important part of the MAES mission."

us plants. "This process is like painting from a palette," Walker said. "We can add select colors to the palette from which the enzyme chooses, so the molecule can be crafted in a variety of ways. The enzyme does all the work.

"A plant enzyme can do in one step what traditional synthetic construction does in multiples steps," Walker said. "Under our process, the construction of Taxol uses a biological assembly line where each enzyme does its job to create the final product. Particular enzymes on the assembly line can attach slightly different components on the molecular frame to create new-generation Taxol molecules. This can lead to more effective drug variants and eventually better health care treatment."

Taxol "is definitely a frontline drug and is used to treat many cancers," including those of the breast, lung, head and neck, said Barbara Conley, chief of the MSU Department of Medicine's hematology and oncology division.

With a world bulk paclitaxel market generating revenues of $195 million in 1997, potential new uses for conditions such as Alzheimer's disease and tuberculosis are expected to help boost the world market 10 percent by 2012, according to Global Industry Analysts Inc.

Walker's team's research was funded by the Michigan Agricultural Experiment Station. "The science and technology of plants and natural systems is becoming increasingly relevant in human medicine as scientists look for greater efficiencies and 'greener' ways of manufacturing drugs and other health care products," said MAES director Steve Pueppke. "Engaging in research that leads to improvements in human and animal health is a large and important part of the MAES mission."


'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Green Tea May Brew Up Healthier Skin
2. Lettuce, leafy greens and E. coli
3. Houston Texans Star Players Ahman Green and Matt Schaub Help Easter Seals, Avondale House and Local Families Tackle Autism
4. ComPsych(R) Corp. Announces Health at Work(SM) Award Winners: Sprint, Erie Insurance, City of Naperville and Green Hills Public Library
5. Statement by Robert Greenstein, Executive Director of the Center on Budget and Policy Priorities, on the New Congressional SCHIP Agreement
6. Green Seal Ramps Up Environmental Standard for Household Cleaners
7. PureCart Systems of Green Bay, Wis., is an Honored Recipient of an iParenting Media Award
8. Kaiser Permanente Named Green Electronics Champion by EPA, Green Electronics Council
9. Walgreens Launches New Health Essentials Catalog and Website for AARP Members Featuring More Than 20,000 Health-Related Products
10. Green Pet Products Introduces a New, Innovative Process to the Small Animal and Bird Litter/Bedding Category
11. A History of Philanthropy Made Green-certified Legend Homes an Easy Choice for Extreme Makeover: Home Edition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Green chemistry' could ease manufacture, boost usefulness of cancer drug
(Date:3/24/2017)... ... 24, 2017 , ... Infectious disease affects billions of people ... States, it’s a threat that is constantly changing and evolving. Mediaplanet's “Fighting Infection” ... strategies for the healthcare community to help decrease the number of completely preventable ...
(Date:3/24/2017)... ... ... The Radiology Business Management Association (RBMA) has named the nine ... 12th year, are among the most prestigious in radiology marketing because a panel of ... to recognize achievements in both large budget (over $5,000) and small budget (under $5,000) ...
(Date:3/24/2017)... San Antonio, TX (PRWEB) , ... March 24, 2017 , ... ... a new clinic which can be found at 9618 Huebner Road. The clinic is ... Thobaben, PT, OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from ...
(Date:3/24/2017)... ... March 24, 2017 , ... Mlynarek Insurance Agencies, a ... and business owners across eastern Michigan, is connecting with the Oxford/Orion FISH Food ... difficulties. , The Oxford/Orion FISH Food Pantry works to ensure homeless, hungry, and ...
(Date:3/24/2017)... Diego, Calif. (PRWEB) , ... March 24, 2017 ... ... has raised over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on ... the instant demand for the product – with nearly 2,000 consumers (and counting) ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... March 23, 2017  HealthMine surveys with 9,250 insured ... that health plan members want help from their plans ... engaged in their health, 2) help closing gaps in ... for health and 5) relevant, real-time guidance. Meeting these ... healthcare costs. A Reason to ...
(Date:3/23/2017)... 2017 Research and Markets has announced the ... Industry Forecast to 2025" report to their offering. ... The Global Cryostat Market ... the next decade to reach approximately $3.5 billion by 2025. ... all the given segments on global as well as regional levels ...
(Date:3/23/2017)... Executive Summary ... primary research (inputs from industry experts, companies, stakeholders) ... the analysis of global heart valve devices market ... Replacement Procedure By Technique (Mechanical, Bioprosthetic, Transcatheter Aortic ... Balloon Valvuloplasty, Transcatheter Mitral Valve Repair (TMVR)), By ...
Breaking Medicine Technology: