Navigation Links
Green Tea May Negate the Effects of a Common Cancer Therapy
Date:2/3/2009

lymphoma, normally fights disease by inhibiting proteasomes and inducing tumor cell death. However, in both in vitro and in vivo mouse experiments, the team was surprised to find that the EGCG compound seemed to prevent bortezomib from fighting the disease by blocking its proteasome inhibitory function -- the two compounds effectively contradicted one another in the cell, leaving nearly 100 percent of the tumor cells intact.

Importantly, the team found that EGCG only reacted with proteasome inhibitors that have a boronic acid base (including bortezomib) but did not react with several non-boronic acid-based proteasome inhibitors (such as nelfinavir [Viracept(R)], a treatment for HIV). The researchers determined that the boronic acid in bortezomib helped to bind the EGCG directly to the therapy molecule, thereby cancelling out the effects of both the green tea and the therapy on the tumor cells.

The study findings may have several important implications in the clinical setting. The EGCG blocked bortezomib's antitumor effects at levels that are commonly achieved with the use of available concentrated green tea supplements (as low as 2.5 micromolars -- which can be attained with two to three 250 mg capsules of green tea extract) suggesting the impact is very real for patients supplementing their therapy. The team also believes that as the EGCG inactivates bortezomib's function in the tumor cell, it may also prevent some of the side effects that usually accompany the therapy. As a result, patients taking green tea products to supplement their therapy may experience improved well being and feel encouraged to increase their intake while unknowingly blunting or completely negating the efficacy of their bortezomib treatment.

"Our surprising results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib," said Dr. Schonthal. "The current evidence is suf
'/>"/>

SOURCE American Society of Hematology
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Milkscreen Home Test for Alcohol in Breast Milk Begins Nationwide Sales at Walgreens
2. Recent U.S. Ambassador to Tanzania Mark Green Named Managing Director of Malaria No More Policy Center
3. Healthcare Sector Leaders Urge Obama, Congress to Invest in Alternative Energy and Green Jobs in Healthcare
4. DSM Joins the American Chemical Society Green Chemistry Institute(R)s Pharmaceutical Roundtable
5. Waking Up And Getting Ready: New Green Guide Advocates Simple Living and Earth-Centered Spirituality
6. CMS Data Services Reports Record Response to Data Media "GREEN" Repurchase Program
7. My1Stop.com Partners with Green Business Alliance to Help Customers Go Green
8. Chicago's First Eco-friendly, Green Luxury Dental Practice - ORA Dental Studio - is Finally Here
9. Greenland's National Management of Health Partners with AMD Global Telemedicine Inc. and AFHCAN to Install Telemedicine Encounter Management Systems (TEMS) Across Greenland
10. Greenway Medical Technologies EHR Solution, PrimeSuite, Wins Three Best in KLAS Awards
11. Be Green with B. Braun: Company Shares Expertise, Environmentally Responsible Products at ASHP 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2014)... CA (PRWEB) September 03, 2014 AttorneyOne.com, a ... the latest information from the FDA on Pedigree nutrition ... August 26, that 22 bags of Pedigree Adult Complete Nutrition ... the possible presence of a foreign material. The reason for ... fragments, which could have entered the packages during the production ...
(Date:9/3/2014)... An inspiring story of the importance ... the season finale of “Extreme Weight Loss” Season Four. ... daughter from Highlands Ranch, Colo. who have a strained ... pounds. Their challenge is to team up to lose ... non-competitive approach to weight loss transformations, “Extreme Weight Loss” ...
(Date:9/3/2014)... September 03, 2014 Pwnie Express today ... cutting edge Pwn Plug, the R3, an inconspicuous pentesting ... of use at remote locations at a fraction of ... Pwnie Express is the only company to assess wired ... Plug R3 is a next-generation penetration testing device in ...
(Date:9/3/2014)... "What can you say about a sixteen-year-old girl who ... Eight in the Margaret of Greenwich (R) Young Adult ... Books, Inc . These novels narrate the lives of a ... in America. , In this thriller, learning geometry becomes the ... student’s murder plot. Her fears increase when Erika, the only ...
(Date:9/2/2014)... dry eye disease include the sensation of grit in ... disturbance. The causes are poorly understood., The researchers base ... 87 (average age 57) from the TwinsUK cohort, drawn ... London., This cohort is widely regarded as representative of ... look at a wide range of diseases and genetic ...
Breaking Medicine News(10 mins):Health News:Pedigree Adult Complete Nutrition for Dogs Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:“Extreme Weight Loss”: Jeff and Juliana’s Journey begin at the University of Colorado Anschutz Health and Wellness Center 2Health News:Pwnie Express Releases Next Generation Penetration Testing Device: The Pwn Plug R3 2Health News:Pwnie Express Releases Next Generation Penetration Testing Device: The Pwn Plug R3 3Health News:Pwnie Express Releases Next Generation Penetration Testing Device: The Pwn Plug R3 4Health News:Town Locked Down After Bombing and Murders in "Margaret and Hillary" - New Book Eight in the Margaret of Greenwich(R) Young Adult Series by R. L. Rhyse 2Health News:Around 1 in 10 UK women has dry eye disease, requiring artificial tears 2
... THURSDAY, March 1 (HealthDay News) -- Where a bird lives ... city dwellers tweeting at a higher pitch than those residing ... recordings, researchers from the University of Copenhagen in Denmark and ... they sing due to city buildings -- not just the ...
... megakaryocytes giant blood cells that produce wound-healing platelets manage ... The findings, to be published March 13 in the journal ... this process may cause a form of leukemia. "A failure ... megakaryoblastic leukemias," said Diane Krause, senior author of the paper, who ...
... THURSDAY, March 1 (HealthDay News) -- Scientists studying mice ... the ability to momentarily retain and utilize information needed ... the March 2 print issue of Cell , ... impairs memory by affecting passive support cells known as ...
... past few decades, doctors have noted a surprising trend ... tongue. Though oral cancer previously appeared predominantly in elderly ... it,s increasing in younger patients: 30- to 50-year-old nonsmokers ... of cancer tends to be less aggressive, and the ...
... HealthDay Reporter , WEDNESDAY, Feb. 29 (HealthDay News) -- ... help people with the rare bone marrow disorder called myelofibrosis. ... the brand name Jakafi, won,t cure myelofibrosis, it can help ... according to the studies. "This is probably the ...
... Aging does not appear to be a factor in poor ... fact, subjective sleep quality seems to improve over a lifetime, with ... flies in the face of popular belief," said Michael Grandner, PhD, ... what we know about sleep in older people men and ...
Cached Medicine News:Health News:City Birds Sing Differently Than Their Country Cousins 2Health News:How red blood cells get so big -- and the bad things that happen when they don't 2Health News:Mayo Clinic: Robotic surgery proves successful, less invasive way to treat HPV-related oral cancer 2Health News:New Drug May Help Fight Rare Bone Marrow Disorder 2Health News:New Drug May Help Fight Rare Bone Marrow Disorder 3Health News:Study: Sleep gets better with age, not worse 2
(Date:9/3/2014)... ,    ... ~   Kiadis Pharma B.V. ... biopharmaceutical company developing T-cell immunotherapy treatments for blood cancers, ... , MD PhD, as its Chief Medical Officer. ... at Ceronco Biosciences. Prior to that he was VP ...
(Date:9/2/2014)... 2014 Reportbuyer.com has added a new ... Technologies for Molecular Imaging Devices ... The objectives of this study are to ... used for diagnostic purposes, present global market measurements ... market segments as well as forecast market and ...
(Date:9/2/2014)... -- Numotion is pleased to announce the appointment of Mark ... Mark is a 30-year retired veteran of GE where ... and was a GE Company Officer since 1999 and a ... running business units within GE Healthcare, with the most recent ... "We are delighted to welcome Mark to our Board," ...
Breaking Medicine Technology:Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 2Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 3Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 4Kiadis Pharma Appoints Jeroen Rovers as its Chief Medical Officer 5Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25
... Tenn., Nov. 18, 2011 MedSolutions , ... services, today announced the launch of its Implantable ... evidence-based guidelines to ensure the clinical appropriateness of ... With the cost of each ICD/CRT-D ...
... Md., Nov. 18, 2011 The U.S. Food and ... ) to treat patients with acute lymphoblastic leukemia (ALL), ... coli derived asparaginase and pegaspargase chemotherapy drugs used ... ) Acute lymphoblastic leukemia is a ...
Cached Medicine Technology:MedSolutions Launches Implantable Cardiac Defibrillator Program to Reduce Unnecessary Surgeries 2MedSolutions Launches Implantable Cardiac Defibrillator Program to Reduce Unnecessary Surgeries 3FDA Approves Erwinaze to Treat a Form of Leukemia 2FDA Approves Erwinaze to Treat a Form of Leukemia 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: